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Fusion gene ID: 38341 |
FusionGeneSummary for TMEFF2_TMPRSS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TMEFF2_TMPRSS2 | Fusion gene ID: 38341 | Hgene | Tgene | Gene symbol | TMEFF2 | TMPRSS2 | Gene ID | 23671 | 7113 |
| Gene name | transmembrane protein with EGF like and two follistatin like domains 2 | transmembrane serine protease 2 | |
| Synonyms | CT120.2|HPP1|TENB2|TPEF|TR|TR-2 | PP9284|PRSS10 | |
| Cytomap | 2q32.3 | 21q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tomoregulin-2cancer/testis antigen family 120, member 2hyperplastic polyposis protein 1transmembrane protein TENB2transmembrane protein with EGF-like and two follistatin-like domains | transmembrane protease serine 2epitheliasinserine protease 10transmembrane protease, serine 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9UIK5 | O15393 | |
| Ensembl transtripts involved in fusion gene | ENST00000392314, ENST00000272771, ENST00000487771, ENST00000409056, | ENST00000332149, ENST00000398585, ENST00000458356, ENST00000497881, | |
| Fusion gene scores | * DoF score | 7 X 4 X 2=56 | 16 X 12 X 3=576 |
| # samples | 8 | 20 | |
| ** MAII score | log2(8/56*10)=0.514573172829758 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(20/576*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TMEFF2 [Title/Abstract] AND TMPRSS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. Tissue-specifically expressed gene involved fusion gene, inframe and retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TMEFF2 | GO:0030336 | negative regulation of cell migration | 24632071 |
| Hgene | TMEFF2 | GO:0044319 | wound healing, spreading of cells | 24632071 |
| Hgene | TMEFF2 | GO:0051497 | negative regulation of stress fiber assembly | 24632071 |
| Tgene | TMPRSS2 | GO:0006508 | proteolysis | 21068237|24227843 |
| Tgene | TMPRSS2 | GO:0046598 | positive regulation of viral entry into host cell | 21068237|24227843 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PRAD | TCGA-KK-A59Y-01A | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000392314 | ENST00000332149 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| Frame-shift | ENST00000392314 | ENST00000398585 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| Frame-shift | ENST00000392314 | ENST00000458356 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| 5CDS-intron | ENST00000392314 | ENST00000497881 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| Frame-shift | ENST00000272771 | ENST00000332149 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| Frame-shift | ENST00000272771 | ENST00000398585 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| Frame-shift | ENST00000272771 | ENST00000458356 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| 5CDS-intron | ENST00000272771 | ENST00000497881 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| intron-3CDS | ENST00000487771 | ENST00000332149 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| intron-3CDS | ENST00000487771 | ENST00000398585 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| intron-3CDS | ENST00000487771 | ENST00000458356 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| intron-intron | ENST00000487771 | ENST00000497881 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| Frame-shift | ENST00000409056 | ENST00000332149 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| Frame-shift | ENST00000409056 | ENST00000398585 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| Frame-shift | ENST00000409056 | ENST00000458356 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
| 5CDS-intron | ENST00000409056 | ENST00000497881 | TMEFF2 | chr2 | 193049080 | - | TMPRSS2 | chr21 | 42851209 | - |
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FusionProtFeatures for TMEFF2_TMPRSS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TMEFF2 | TMPRSS2 |