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Fusion gene ID: 38227 |
FusionGeneSummary for TM9SF1_NPAS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TM9SF1_NPAS3 | Fusion gene ID: 38227 | Hgene | Tgene | Gene symbol | TM9SF1 | NPAS3 | Gene ID | 10548 | 64067 |
| Gene name | transmembrane 9 superfamily member 1 | neuronal PAS domain protein 3 | |
| Synonyms | HMP70|MP70 | MOP6|PASD6|bHLHe12 | |
| Cytomap | 14q12 | 14q13.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane 9 superfamily member 1MP70 protein family membermultispanning membrane protein (70kD)transmembrane protein 9 superfamily member 1 | neuronal PAS domain-containing protein 3PAS domain-containing protein 6basic-helix-loop-helix-PAS protein MOP6class E basic helix-loop-helix protein 12member of PAS protein 6neuronal PAS3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O15321 | Q8IXF0 | |
| Ensembl transtripts involved in fusion gene | ENST00000261789, ENST00000528669, ENST00000556387, ENST00000530611, ENST00000524835, ENST00000396854, | ENST00000551492, ENST00000346562, ENST00000341321, ENST00000548645, ENST00000356141, ENST00000357798, ENST00000547068, ENST00000551008, ENST00000550662, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 9 X 7 X 6=378 |
| # samples | 3 | 10 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(10/378*10)=-1.91838623444635 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TM9SF1 [Title/Abstract] AND NPAS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-78-7155-01A | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000261789 | ENST00000551492 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000261789 | ENST00000346562 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000261789 | ENST00000341321 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000261789 | ENST00000548645 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000261789 | ENST00000356141 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000261789 | ENST00000357798 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000261789 | ENST00000547068 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000261789 | ENST00000551008 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000261789 | ENST00000550662 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000528669 | ENST00000551492 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000528669 | ENST00000346562 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000528669 | ENST00000341321 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000528669 | ENST00000548645 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000528669 | ENST00000356141 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000528669 | ENST00000357798 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000528669 | ENST00000547068 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000528669 | ENST00000551008 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000528669 | ENST00000550662 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556387 | ENST00000551492 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556387 | ENST00000346562 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556387 | ENST00000341321 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556387 | ENST00000548645 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556387 | ENST00000356141 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556387 | ENST00000357798 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556387 | ENST00000547068 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000556387 | ENST00000551008 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000556387 | ENST00000550662 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000530611 | ENST00000551492 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000530611 | ENST00000346562 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000530611 | ENST00000341321 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000530611 | ENST00000548645 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000530611 | ENST00000356141 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000530611 | ENST00000357798 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000530611 | ENST00000547068 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000530611 | ENST00000551008 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000530611 | ENST00000550662 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000524835 | ENST00000551492 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000524835 | ENST00000346562 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000524835 | ENST00000341321 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000524835 | ENST00000548645 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000524835 | ENST00000356141 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000524835 | ENST00000357798 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000524835 | ENST00000547068 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000524835 | ENST00000551008 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000524835 | ENST00000550662 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396854 | ENST00000551492 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396854 | ENST00000346562 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396854 | ENST00000341321 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396854 | ENST00000548645 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396854 | ENST00000356141 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396854 | ENST00000357798 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396854 | ENST00000547068 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-intron | ENST00000396854 | ENST00000551008 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
| 5CDS-3UTR | ENST00000396854 | ENST00000550662 | TM9SF1 | chr14 | 24661854 | - | NPAS3 | chr14 | 34081611 | + |
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FusionProtFeatures for TM9SF1_NPAS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TM9SF1 | NPAS3 |