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Fusion gene ID: 38199 |
FusionGeneSummary for TLN1_SFTPB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TLN1_SFTPB | Fusion gene ID: 38199 | Hgene | Tgene | Gene symbol | TLN1 | SFTPB | Gene ID | 7094 | 6439 |
| Gene name | talin 1 | surfactant protein B | |
| Synonyms | ILWEQ|TLN|talin-1 | PSP-B|SFTB3|SFTP3|SMDP1|SP-B | |
| Cytomap | 9p13.3 | 2p11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | talin-1 | pulmonary surfactant-associated protein B18 kDa pulmonary-surfactant protein6 kDa proteinpulmonary surfactant-associated proteolipid SPL(Phe) | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q9Y490 | P07988 | |
| Ensembl transtripts involved in fusion gene | ENST00000314888, ENST00000540444, ENST00000464379, | ENST00000519937, ENST00000342375, ENST00000393822, ENST00000409383, | |
| Fusion gene scores | * DoF score | 7 X 10 X 3=210 | 12 X 10 X 2=240 |
| # samples | 10 | 14 | |
| ** MAII score | log2(10/210*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/240*10)=-0.777607578663552 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TLN1 [Title/Abstract] AND SFTPB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-05-4426-01A | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| TCGA | LD | LUAD | TCGA-75-6206-01A | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000314888 | ENST00000519937 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000314888 | ENST00000342375 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000314888 | ENST00000393822 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-intron | ENST00000314888 | ENST00000409383 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000540444 | ENST00000519937 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000540444 | ENST00000342375 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000540444 | ENST00000393822 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-intron | ENST00000540444 | ENST00000409383 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| intron-3UTR | ENST00000464379 | ENST00000519937 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| intron-3UTR | ENST00000464379 | ENST00000342375 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| intron-3UTR | ENST00000464379 | ENST00000393822 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| intron-intron | ENST00000464379 | ENST00000409383 | TLN1 | chr9 | 35716387 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000314888 | ENST00000519937 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000314888 | ENST00000342375 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000314888 | ENST00000393822 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-intron | ENST00000314888 | ENST00000409383 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000540444 | ENST00000519937 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000540444 | ENST00000342375 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000540444 | ENST00000393822 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-intron | ENST00000540444 | ENST00000409383 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000464379 | ENST00000519937 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000464379 | ENST00000342375 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-3UTR | ENST00000464379 | ENST00000393822 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
| 5CDS-intron | ENST00000464379 | ENST00000409383 | TLN1 | chr9 | 35703557 | - | SFTPB | chr2 | 85886805 | - |
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FusionProtFeatures for TLN1_SFTPB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TLN1 | SFTPB |