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Fusion gene ID: 38193

FusionGeneSummary for TLK2_THRA

Fusion gene summary

Fusion gene information	Fusion gene name: TLK2_THRA
	Fusion gene ID: 38193
		Hgene	Tgene
	Gene symbol	TLK2	THRA
	Gene ID	11011	7067
	Gene name	tousled like kinase 2	thyroid hormone receptor alpha
	Synonyms	HsHPK\|PKU-ALPHA	AR7\|CHNG6\|EAR7\|ERB-T-1\|ERBA\|ERBA1\|NR1A1\|THRA1\|THRA2\|c-ERBA-1
	Cytomap	17q23.2	17q21.1
	Type of gene	protein-coding	protein-coding
	Description	serine/threonine-protein kinase tousled-like 2	thyroid hormone receptor alphaEAR-7ERBA-related 7V-erbA-related protein 7c-erbA-alphanuclear receptor subfamily 1 group A member 1thyroid hormone receptor alpha 1thyroid hormone receptor, alpha (erythroblastic leukemia viral (v-erb-a) oncogene homo
	Modification date	20180519	20180523
	UniProtAcc	Q86UE8	P10827
	Ensembl transtripts involved in fusion gene	ENST00000582809, ENST00000577616, ENST00000326270, ENST00000346027, ENST00000343388, ENST00000542523,	ENST00000394121, ENST00000264637, ENST00000584985, ENST00000450525, ENST00000546243,
Fusion gene scores	* DoF score	10 X 6 X 6=360	6 X 5 X 5=150
	# samples	10	8
	** MAII score	log2(10/360*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/150*10)=-0.906890595608519 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TLK2 [Title/Abstract] AND THRA [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TLK2	GO:0001672	regulation of chromatin assembly or disassembly	12660173
Hgene	TLK2	GO:0006468	protein phosphorylation	12660173
Hgene	TLK2	GO:0006974	cellular response to DNA damage stimulus	12660173
Hgene	TLK2	GO:0018105	peptidyl-serine phosphorylation	20016786
Hgene	TLK2	GO:0035556	intracellular signal transduction	12660173
Hgene	TLK2	GO:0071480	cellular response to gamma radiation	12660173
Tgene	THRA	GO:0006357	regulation of transcription by RNA polymerase II	18052923
Tgene	THRA	GO:0006366	transcription by RNA polymerase II	8710870\|9653119
Tgene	THRA	GO:0009755	hormone-mediated signaling pathway	18052923
Tgene	THRA	GO:0017055	negative regulation of RNA polymerase II transcriptional preinitiation complex assembly	8524305
Tgene	THRA	GO:0045892	negative regulation of transcription, DNA-templated	8710870
Tgene	THRA	GO:2000143	negative regulation of DNA-templated transcription, initiation	8524305

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	LD	BLCA	TCGA-FD-A43P-01A	TLK2	chr17	60613698	+	THRA	chr17	38240088	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000582809	ENST00000394121	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000582809	ENST00000264637	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000582809	ENST00000584985	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000582809	ENST00000450525	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000582809	ENST00000546243	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
intron-3CDS	ENST00000577616	ENST00000394121	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
intron-3CDS	ENST00000577616	ENST00000264637	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
intron-3CDS	ENST00000577616	ENST00000584985	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
intron-3CDS	ENST00000577616	ENST00000450525	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
intron-3CDS	ENST00000577616	ENST00000546243	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000326270	ENST00000394121	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000326270	ENST00000264637	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000326270	ENST00000584985	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000326270	ENST00000450525	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000326270	ENST00000546243	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000346027	ENST00000394121	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000346027	ENST00000264637	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000346027	ENST00000584985	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000346027	ENST00000450525	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000346027	ENST00000546243	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000343388	ENST00000394121	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000343388	ENST00000264637	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000343388	ENST00000584985	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000343388	ENST00000450525	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000343388	ENST00000546243	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000542523	ENST00000394121	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000542523	ENST00000264637	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000542523	ENST00000584985	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000542523	ENST00000450525	TLK2	chr17	60613698	+	THRA	chr17	38240088	+
In-frame	ENST00000542523	ENST00000546243	TLK2	chr17	60613698	+	THRA	chr17	38240088	+

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FusionProtFeatures for TLK2_THRA

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TLK2 Q86UE8	THRA P10827

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Fusion gene ID: 38193

FusionGeneSummary for TLK2_THRA

FusionProtFeatures for TLK2_THRA