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Fusion gene ID: 38162 |
FusionGeneSummary for TLCD2_LRP5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TLCD2_LRP5 | Fusion gene ID: 38162 | Hgene | Tgene | Gene symbol | TLCD2 | LRP5 | Gene ID | 727910 | 4041 |
| Gene name | TLC domain containing 2 | LDL receptor related protein 5 | |
| Synonyms | - | BMND1|EVR1|EVR4|HBM|LR3|LRP-5|LRP7|OPPG|OPS|OPTA1|PCLD4|VBCH2 | |
| Cytomap | 17p13.3 | 11q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TLC domain-containing protein 2 | low-density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 5low density lipoprotein receptor-related protein 7 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | A6NGC4 | O75197 | |
| Ensembl transtripts involved in fusion gene | ENST00000330676, | ENST00000294304, ENST00000529481, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 10 X 9 X 7=630 |
| # samples | 2 | 12 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(12/630*10)=-2.39231742277876 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TLCD2 [Title/Abstract] AND LRP5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | LRP5 | GO:0008284 | positive regulation of cell proliferation | 9790987 |
| Tgene | LRP5 | GO:0016055 | Wnt signaling pathway | 17955262 |
| Tgene | LRP5 | GO:0044332 | Wnt signaling pathway involved in dorsal/ventral axis specification | 11029007 |
| Tgene | LRP5 | GO:0045840 | positive regulation of mitotic nuclear division | 9790987 |
| Tgene | LRP5 | GO:0045893 | positive regulation of transcription, DNA-templated | 15035989|17955262 |
| Tgene | LRP5 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12857724 |
| Tgene | LRP5 | GO:0060070 | canonical Wnt signaling pathway | 12121999|12857724|15035989 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ACC | TCGA-OR-A5K2-01A | TLCD2 | chr17 | 1612793 | - | LRP5 | chr11 | 68177382 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000330676 | ENST00000294304 | TLCD2 | chr17 | 1612793 | - | LRP5 | chr11 | 68177382 | + |
| 5CDS-intron | ENST00000330676 | ENST00000529481 | TLCD2 | chr17 | 1612793 | - | LRP5 | chr11 | 68177382 | + |
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FusionProtFeatures for TLCD2_LRP5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TLCD2 | LRP5 |