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Fusion gene ID: 38096 |
FusionGeneSummary for TIMELESS_RPS15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TIMELESS_RPS15 | Fusion gene ID: 38096 | Hgene | Tgene | Gene symbol | TIMELESS | RPS15 | Gene ID | 8914 | 6209 |
| Gene name | timeless circadian regulator | ribosomal protein S15 | |
| Synonyms | TIM|TIM1|hTIM | RIG|S15 | |
| Cytomap | 12q13.3 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein timeless homologTof1 homologtimeless circadian clock 1timeless homolog | 40S ribosomal protein S15homolog of rat insulinomainsulinoma proteinsmall ribosomal subunit protein uS19 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UNS1 | P62841 | |
| Ensembl transtripts involved in fusion gene | ENST00000229201, ENST00000553532, ENST00000554616, | ENST00000233609, ENST00000586686, ENST00000591032, ENST00000589656, ENST00000593052, ENST00000591804, ENST00000586096, ENST00000585665, | |
| Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 1 X 1 X 1=1 |
| # samples | 3 | 1 | |
| ** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TIMELESS [Title/Abstract] AND RPS15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TIMELESS | GO:0045892 | negative regulation of transcription, DNA-templated | 9856465 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | H38868 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000229201 | ENST00000233609 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000229201 | ENST00000586686 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000229201 | ENST00000591032 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000229201 | ENST00000589656 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000229201 | ENST00000593052 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000229201 | ENST00000591804 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3UTR | ENST00000229201 | ENST00000586096 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3UTR | ENST00000229201 | ENST00000585665 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000553532 | ENST00000233609 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000553532 | ENST00000586686 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000553532 | ENST00000591032 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000553532 | ENST00000589656 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000553532 | ENST00000593052 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000553532 | ENST00000591804 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3UTR | ENST00000553532 | ENST00000586096 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3UTR | ENST00000553532 | ENST00000585665 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000554616 | ENST00000233609 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000554616 | ENST00000586686 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000554616 | ENST00000591032 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000554616 | ENST00000589656 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000554616 | ENST00000593052 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3CDS | ENST00000554616 | ENST00000591804 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3UTR | ENST00000554616 | ENST00000586096 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
| intron-3UTR | ENST00000554616 | ENST00000585665 | TIMELESS | chr12 | 56813379 | - | RPS15 | chr19 | 1440425 | + |
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FusionProtFeatures for TIMELESS_RPS15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TIMELESS | RPS15 |