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Fusion gene ID: 3809 |
FusionGeneSummary for BAIAP2L1_ANKIB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BAIAP2L1_ANKIB1 | Fusion gene ID: 3809 | Hgene | Tgene | Gene symbol | BAIAP2L1 | ANKIB1 | Gene ID | 55971 | 54467 |
| Gene name | BAI1 associated protein 2 like 1 | ankyrin repeat and IBR domain containing 1 | |
| Synonyms | IRTKS | - | |
| Cytomap | 7q21.3-q22.1 | 7q21.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1BAI1-associated protein 2-like protein 1insulin receptor tyrosine kinase substrate | ankyrin repeat and IBR domain-containing protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UHR4 | Q9P2G1 | |
| Ensembl transtripts involved in fusion gene | ENST00000005260, ENST00000462558, | ENST00000265742, ENST00000486698, | |
| Fusion gene scores | * DoF score | 7 X 4 X 6=168 | 6 X 3 X 6=108 |
| # samples | 7 | 8 | |
| ** MAII score | log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/108*10)=-0.432959407276106 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BAIAP2L1 [Title/Abstract] AND ANKIB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | BAIAP2L1 | GO:0009617 | response to bacterium | 19366662 |
| Hgene | BAIAP2L1 | GO:0030838 | positive regulation of actin filament polymerization | 21098279 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | ESCA | TCGA-L5-A8NF-01A | BAIAP2L1 | chr7 | 97933508 | - | ANKIB1 | chr7 | 91924203 | + |
| TCGA | LD | LUSC | TCGA-56-A4BW-01A | BAIAP2L1 | chr7 | 98030114 | - | ANKIB1 | chr7 | 91924203 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000005260 | ENST00000265742 | BAIAP2L1 | chr7 | 97933508 | - | ANKIB1 | chr7 | 91924203 | + |
| 5CDS-intron | ENST00000005260 | ENST00000486698 | BAIAP2L1 | chr7 | 97933508 | - | ANKIB1 | chr7 | 91924203 | + |
| intron-5UTR | ENST00000462558 | ENST00000265742 | BAIAP2L1 | chr7 | 97933508 | - | ANKIB1 | chr7 | 91924203 | + |
| intron-intron | ENST00000462558 | ENST00000486698 | BAIAP2L1 | chr7 | 97933508 | - | ANKIB1 | chr7 | 91924203 | + |
| 5CDS-5UTR | ENST00000005260 | ENST00000265742 | BAIAP2L1 | chr7 | 98030114 | - | ANKIB1 | chr7 | 91924203 | + |
| 5CDS-intron | ENST00000005260 | ENST00000486698 | BAIAP2L1 | chr7 | 98030114 | - | ANKIB1 | chr7 | 91924203 | + |
| 5UTR-5UTR | ENST00000462558 | ENST00000265742 | BAIAP2L1 | chr7 | 98030114 | - | ANKIB1 | chr7 | 91924203 | + |
| 5UTR-intron | ENST00000462558 | ENST00000486698 | BAIAP2L1 | chr7 | 98030114 | - | ANKIB1 | chr7 | 91924203 | + |
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FusionProtFeatures for BAIAP2L1_ANKIB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BAIAP2L1 | ANKIB1 |