|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 38086 |
FusionGeneSummary for TIAM2_TFB1M |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TIAM2_TFB1M | Fusion gene ID: 38086 | Hgene | Tgene | Gene symbol | TIAM2 | TFB1M | Gene ID | 26230 | 51106 |
| Gene name | T cell lymphoma invasion and metastasis 2 | transcription factor B1, mitochondrial | |
| Synonyms | STEF|TIAM-2 | CGI-75|CGI75|mtTFB|mtTFB1 | |
| Cytomap | 6q25.2-q25.3 | 6q25.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-lymphoma invasion and metastasis-inducing protein 2SIF and TIAM1-like exchange factor | dimethyladenosine transferase 1, mitochondrialS-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 1h-mtTFB1hTFB1Mhomolog of yeast mitochondrial transcription factor Bmitochondrial 12S rRNA dimethylase 1mitochondrial dimethyladenosine tr | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8IVF5 | Q8WVM0 | |
| Ensembl transtripts involved in fusion gene | ENST00000461783, ENST00000449545, ENST00000367174, ENST00000456144, ENST00000318981, ENST00000360366, ENST00000529824, ENST00000456877, ENST00000528391, ENST00000275246, | ENST00000367166, ENST00000480390, | |
| Fusion gene scores | * DoF score | 8 X 8 X 3=192 | 2 X 2 X 2=8 |
| # samples | 10 | 3 | |
| ** MAII score | log2(10/192*10)=-0.941106310946431 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/8*10)=1.90689059560852 | |
| Context | PubMed: TIAM2 [Title/Abstract] AND TFB1M [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BM993771 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - | ||
| ChiTaRS3.1 | CN479315 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000461783 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000461783 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| intron-3CDS | ENST00000449545 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| intron-intron | ENST00000449545 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| Frame-shift | ENST00000367174 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000367174 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| Frame-shift | ENST00000456144 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000456144 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| Frame-shift | ENST00000318981 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000318981 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| Frame-shift | ENST00000360366 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000360366 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| In-frame | ENST00000529824 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000529824 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| Frame-shift | ENST00000456877 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000456877 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| In-frame | ENST00000528391 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000528391 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| In-frame | ENST00000275246 | ENST00000367166 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
| 5CDS-intron | ENST00000275246 | ENST00000480390 | TIAM2 | chr6 | 155578137 | - | TFB1M | chr6 | 155581444 | - |
Top |
FusionProtFeatures for TIAM2_TFB1M |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TIAM2 | TFB1M |