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Fusion gene ID: 38078 |
FusionGeneSummary for TIAM1_PCBP3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TIAM1_PCBP3 | Fusion gene ID: 38078 | Hgene | Tgene | Gene symbol | TIAM1 | PCBP3 | Gene ID | 7074 | 54039 |
| Gene name | T cell lymphoma invasion and metastasis 1 | poly(rC) binding protein 3 | |
| Synonyms | TIAM-1 | ALPHA-CP3|PCBP3-OT1|PCBP3OT | |
| Cytomap | 21q22.11 | 21q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-lymphoma invasion and metastasis-inducing protein 1human T-lymphoma invasion and metastasis inducing TIAM1 protein | poly(rC)-binding protein 3PCBP3 overlapping transcript 1PCBP3-overlapping transcriptpoly(rC) binding protein 3 overlapping transcript | |
| Modification date | 20180522 | 20180519 | |
| UniProtAcc | Q13009 | P57721 | |
| Ensembl transtripts involved in fusion gene | ENST00000286827, ENST00000541036, ENST00000469412, | ENST00000400314, ENST00000400310, ENST00000449640, ENST00000400309, ENST00000400308, ENST00000400304, ENST00000423045, | |
| Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 4 X 4 X 4=64 |
| # samples | 9 | 4 | |
| ** MAII score | log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TIAM1 [Title/Abstract] AND PCBP3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TIAM1 | GO:0008284 | positive regulation of cell proliferation | 25032858 |
| Hgene | TIAM1 | GO:0010717 | regulation of epithelial to mesenchymal transition | 20826792 |
| Hgene | TIAM1 | GO:0030335 | positive regulation of cell migration | 25032858 |
| Hgene | TIAM1 | GO:0032092 | positive regulation of protein binding | 23109420 |
| Hgene | TIAM1 | GO:0090630 | activation of GTPase activity | 23109420 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-CR-7367-01A | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000286827 | ENST00000400314 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-3CDS | ENST00000286827 | ENST00000400310 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-3CDS | ENST00000286827 | ENST00000449640 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-3CDS | ENST00000286827 | ENST00000400309 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-3CDS | ENST00000286827 | ENST00000400308 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-intron | ENST00000286827 | ENST00000400304 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-intron | ENST00000286827 | ENST00000423045 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| intron-3CDS | ENST00000541036 | ENST00000400314 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| intron-3CDS | ENST00000541036 | ENST00000400310 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| intron-3CDS | ENST00000541036 | ENST00000449640 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| intron-3CDS | ENST00000541036 | ENST00000400309 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| intron-3CDS | ENST00000541036 | ENST00000400308 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| intron-intron | ENST00000541036 | ENST00000400304 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| intron-intron | ENST00000541036 | ENST00000423045 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-3CDS | ENST00000469412 | ENST00000400314 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-3CDS | ENST00000469412 | ENST00000400310 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-3CDS | ENST00000469412 | ENST00000449640 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-3CDS | ENST00000469412 | ENST00000400309 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-3CDS | ENST00000469412 | ENST00000400308 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-intron | ENST00000469412 | ENST00000400304 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
| 5UTR-intron | ENST00000469412 | ENST00000423045 | TIAM1 | chr21 | 32711558 | - | PCBP3 | chr21 | 47316122 | + |
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FusionProtFeatures for TIAM1_PCBP3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TIAM1 | PCBP3 |