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Fusion gene ID: 38074 |
FusionGeneSummary for TIAM1_HELZ |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TIAM1_HELZ | Fusion gene ID: 38074 | Hgene | Tgene | Gene symbol | TIAM1 | HELZ | Gene ID | 7074 | 9931 |
| Gene name | T cell lymphoma invasion and metastasis 1 | helicase with zinc finger | |
| Synonyms | TIAM-1 | DHRC|DRHC|HUMORF5 | |
| Cytomap | 21q22.11 | 17q24.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | T-lymphoma invasion and metastasis-inducing protein 1human T-lymphoma invasion and metastasis inducing TIAM1 protein | probable helicase with zinc finger domaindown-regulated in human cancers proteinhelicase with zinc finger domain | |
| Modification date | 20180522 | 20180526 | |
| UniProtAcc | Q13009 | P42694 | |
| Ensembl transtripts involved in fusion gene | ENST00000286827, ENST00000541036, ENST00000469412, | ENST00000358691, ENST00000580168, ENST00000580662, | |
| Fusion gene scores | * DoF score | 8 X 5 X 5=200 | 6 X 5 X 3=90 |
| # samples | 9 | 5 | |
| ** MAII score | log2(9/200*10)=-1.15200309344505 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/90*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TIAM1 [Title/Abstract] AND HELZ [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TIAM1 | GO:0008284 | positive regulation of cell proliferation | 25032858 |
| Hgene | TIAM1 | GO:0010717 | regulation of epithelial to mesenchymal transition | 20826792 |
| Hgene | TIAM1 | GO:0030335 | positive regulation of cell migration | 25032858 |
| Hgene | TIAM1 | GO:0032092 | positive regulation of protein binding | 23109420 |
| Hgene | TIAM1 | GO:0090630 | activation of GTPase activity | 23109420 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | L44394 | TIAM1 | chr21 | 32850277 | + | HELZ | chr17 | 65080033 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000286827 | ENST00000358691 | TIAM1 | chr21 | 32850277 | + | HELZ | chr17 | 65080033 | + |
| intron-intron | ENST00000286827 | ENST00000580168 | TIAM1 | chr21 | 32850277 | + | HELZ | chr17 | 65080033 | + |
| intron-intron | ENST00000286827 | ENST00000580662 | TIAM1 | chr21 | 32850277 | + | HELZ | chr17 | 65080033 | + |
| intron-intron | ENST00000541036 | ENST00000358691 | TIAM1 | chr21 | 32850277 | + | HELZ | chr17 | 65080033 | + |
| intron-intron | ENST00000541036 | ENST00000580168 | TIAM1 | chr21 | 32850277 | + | HELZ | chr17 | 65080033 | + |
| intron-intron | ENST00000541036 | ENST00000580662 | TIAM1 | chr21 | 32850277 | + | HELZ | chr17 | 65080033 | + |
| intron-intron | ENST00000469412 | ENST00000358691 | TIAM1 | chr21 | 32850277 | + | HELZ | chr17 | 65080033 | + |
| intron-intron | ENST00000469412 | ENST00000580168 | TIAM1 | chr21 | 32850277 | + | HELZ | chr17 | 65080033 | + |
| intron-intron | ENST00000469412 | ENST00000580662 | TIAM1 | chr21 | 32850277 | + | HELZ | chr17 | 65080033 | + |
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FusionProtFeatures for TIAM1_HELZ |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TIAM1 | HELZ |