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Fusion gene ID: 38041 |
FusionGeneSummary for THSD4_ADAM10 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: THSD4_ADAM10 | Fusion gene ID: 38041 | Hgene | Tgene | Gene symbol | THSD4 | ADAM10 | Gene ID | 79875 | 102 |
| Gene name | thrombospondin type 1 domain containing 4 | ADAM metallopeptidase domain 10 | |
| Synonyms | ADAMTSL-6|ADAMTSL6|FVSY9334|PRO34005 | AD10|AD18|CD156c|CDw156|HsT18717|MADM|RAK|kuz | |
| Cytomap | 15q23 | 15q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thrombospondin type-1 domain-containing protein 4A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6ADAMTS-like protein 6thrombospondin, type I, domain containing 4 | disintegrin and metalloproteinase domain-containing protein 10a disintegrin and metalloprotease domain 10kuzbanian protein homologmammalian disintegrin-metalloprotease | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q6ZMP0 | O14672 | |
| Ensembl transtripts involved in fusion gene | ENST00000355327, ENST00000261862, ENST00000357769, ENST00000567838, | ENST00000260408, ENST00000402627, ENST00000561288, ENST00000396140, ENST00000558733, | |
| Fusion gene scores | * DoF score | 9 X 8 X 7=504 | 4 X 4 X 4=64 |
| # samples | 15 | 4 | |
| ** MAII score | log2(15/504*10)=-1.74846123300404 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: THSD4 [Title/Abstract] AND ADAM10 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ADAM10 | GO:0006509 | membrane protein ectodomain proteolysis | 12714508|17557115|18355449|18419754|18676862|19114711 |
| Tgene | ADAM10 | GO:0007162 | negative regulation of cell adhesion | 12714508 |
| Tgene | ADAM10 | GO:0034612 | response to tumor necrosis factor | 11831872 |
| Tgene | ADAM10 | GO:0051089 | constitutive protein ectodomain proteolysis | 12714508 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | STAD | TCGA-CG-4444-01A | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000355327 | ENST00000260408 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| 5CDS-intron | ENST00000355327 | ENST00000402627 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| 5CDS-intron | ENST00000355327 | ENST00000561288 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| 5CDS-intron | ENST00000355327 | ENST00000396140 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| 5CDS-5UTR | ENST00000355327 | ENST00000558733 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| In-frame | ENST00000261862 | ENST00000260408 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| 5CDS-intron | ENST00000261862 | ENST00000402627 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| 5CDS-intron | ENST00000261862 | ENST00000561288 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| 5CDS-intron | ENST00000261862 | ENST00000396140 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| 5CDS-5UTR | ENST00000261862 | ENST00000558733 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| intron-3CDS | ENST00000357769 | ENST00000260408 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| intron-intron | ENST00000357769 | ENST00000402627 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| intron-intron | ENST00000357769 | ENST00000561288 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| intron-intron | ENST00000357769 | ENST00000396140 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| intron-5UTR | ENST00000357769 | ENST00000558733 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| intron-3CDS | ENST00000567838 | ENST00000260408 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| intron-intron | ENST00000567838 | ENST00000402627 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| intron-intron | ENST00000567838 | ENST00000561288 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| intron-intron | ENST00000567838 | ENST00000396140 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
| intron-5UTR | ENST00000567838 | ENST00000558733 | THSD4 | chr15 | 71549054 | + | ADAM10 | chr15 | 58957396 | - |
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FusionProtFeatures for THSD4_ADAM10 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| THSD4 | ADAM10 |