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Fusion gene ID: 37991 |
FusionGeneSummary for THOC2_SEC62 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: THOC2_SEC62 | Fusion gene ID: 37991 | Hgene | Tgene | Gene symbol | THOC2 | SEC62 | Gene ID | 57187 | 7095 |
| Gene name | THO complex 2 | SEC62 homolog, preprotein translocation factor | |
| Synonyms | CXorf3|MRX12|MRX35|THO2|dJ506G2.1|hTREX120 | Dtrp1|HTP1|TLOC1|TP-1 | |
| Cytomap | Xq25 | 3q26.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | THO complex subunit 2mental retardation, X-linked 12mental retardation, X-linked 35 | translocation protein SEC62SEC62 preprotein translocation factorhTP-1membrane protein SEC62, S.cerevisiae, homolog oftranslocation protein 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q8NI27 | Q99442 | |
| Ensembl transtripts involved in fusion gene | ENST00000245838, ENST00000355725, ENST00000491737, ENST00000497887, | ENST00000337002, ENST00000480708, ENST00000470355, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 6 X 9 X 3=162 |
| # samples | 2 | 11 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(11/162*10)=-0.558490289359965 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: THOC2 [Title/Abstract] AND SEC62 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | THOC2 | GO:0006406 | mRNA export from nucleus | 17190602 |
| Hgene | THOC2 | GO:0016973 | poly(A)+ mRNA export from nucleus | 22928037 |
| Hgene | THOC2 | GO:0046784 | viral mRNA export from host cell nucleus | 18974867 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW362972 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000245838 | ENST00000337002 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3CDS | ENST00000245838 | ENST00000480708 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3UTR | ENST00000245838 | ENST00000470355 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3CDS | ENST00000355725 | ENST00000337002 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3CDS | ENST00000355725 | ENST00000480708 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3UTR | ENST00000355725 | ENST00000470355 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3CDS | ENST00000491737 | ENST00000337002 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3CDS | ENST00000491737 | ENST00000480708 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3UTR | ENST00000491737 | ENST00000470355 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3CDS | ENST00000497887 | ENST00000337002 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3CDS | ENST00000497887 | ENST00000480708 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
| intron-3UTR | ENST00000497887 | ENST00000470355 | THOC2 | chrX | 122761917 | - | SEC62 | chr3 | 169706028 | + |
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FusionProtFeatures for THOC2_SEC62 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| THOC2 | SEC62 |