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Fusion gene ID: 37974 |
FusionGeneSummary for THBS1_ZNF587 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: THBS1_ZNF587 | Fusion gene ID: 37974 | Hgene | Tgene | Gene symbol | THBS1 | ZNF587 | Gene ID | 7057 | 84914 |
| Gene name | thrombospondin 1 | zinc finger protein 587 | |
| Synonyms | THBS|THBS-1|TSP|TSP-1|TSP1 | ZF6 | |
| Cytomap | 15q14 | 19q13.43 | |
| Type of gene | protein-coding | protein-coding | |
| Description | thrombospondin-1thrombospondin-1p180thrombospondin-p50 | zinc finger protein 587zinc finger protein zfp6 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P07996 | Q96SQ5 | |
| Ensembl transtripts involved in fusion gene | ENST00000260356, | ENST00000339656, ENST00000423137, ENST00000419854, ENST00000596433, | |
| Fusion gene scores | * DoF score | 6 X 6 X 2=72 | 2 X 2 X 1=4 |
| # samples | 7 | 2 | |
| ** MAII score | log2(7/72*10)=-0.0406419844973459 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: THBS1 [Title/Abstract] AND ZNF587 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | THBS1 | GO:0001937 | negative regulation of endothelial cell proliferation | 16150726|17996481 |
| Hgene | THBS1 | GO:0001953 | negative regulation of cell-matrix adhesion | 16150726|17416590 |
| Hgene | THBS1 | GO:0002581 | negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II | 16882710 |
| Hgene | THBS1 | GO:0002605 | negative regulation of dendritic cell antigen processing and presentation | 16882710 |
| Hgene | THBS1 | GO:0006954 | inflammatory response | 23144964 |
| Hgene | THBS1 | GO:0007050 | cell cycle arrest | 17596205 |
| Hgene | THBS1 | GO:0008284 | positive regulation of cell proliferation | 24615654 |
| Hgene | THBS1 | GO:0009749 | response to glucose | 18096704 |
| Hgene | THBS1 | GO:0010595 | positive regulation of endothelial cell migration | 18555217 |
| Hgene | THBS1 | GO:0010596 | negative regulation of endothelial cell migration | 18555217 |
| Hgene | THBS1 | GO:0010748 | negative regulation of plasma membrane long-chain fatty acid transport | 17416590 |
| Hgene | THBS1 | GO:0010751 | negative regulation of nitric oxide mediated signal transduction | 16150726|17416590 |
| Hgene | THBS1 | GO:0010754 | negative regulation of cGMP-mediated signaling | 17416590 |
| Hgene | THBS1 | GO:0010757 | negative regulation of plasminogen activation | 6438154 |
| Hgene | THBS1 | GO:0010763 | positive regulation of fibroblast migration | 18555217 |
| Hgene | THBS1 | GO:0016477 | cell migration | 18555217 |
| Hgene | THBS1 | GO:0016525 | negative regulation of angiogenesis | 16150726|17596205|17996481|18726995 |
| Hgene | THBS1 | GO:0018149 | peptide cross-linking | 3997886 |
| Hgene | THBS1 | GO:0030194 | positive regulation of blood coagulation | 3997886 |
| Hgene | THBS1 | GO:0030335 | positive regulation of cell migration | 15700281 |
| Hgene | THBS1 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway | 18555217 |
| Hgene | THBS1 | GO:0030823 | regulation of cGMP metabolic process | 16150726 |
| Hgene | THBS1 | GO:0032026 | response to magnesium ion | 6777381 |
| Hgene | THBS1 | GO:0032695 | negative regulation of interleukin-12 production | 16882710 |
| Hgene | THBS1 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway | 17996481 |
| Hgene | THBS1 | GO:0042535 | positive regulation of tumor necrosis factor biosynthetic process | 18726995 |
| Hgene | THBS1 | GO:0043032 | positive regulation of macrophage activation | 18757424 |
| Hgene | THBS1 | GO:0043066 | negative regulation of apoptotic process | 18653767 |
| Hgene | THBS1 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process | 18653767 |
| Hgene | THBS1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 18555217 |
| Hgene | THBS1 | GO:0043537 | negative regulation of blood vessel endothelial cell migration | 18555217 |
| Hgene | THBS1 | GO:0043652 | engulfment of apoptotic cell | 16882710 |
| Hgene | THBS1 | GO:0045727 | positive regulation of translation | 15700281 |
| Hgene | THBS1 | GO:0048661 | positive regulation of smooth muscle cell proliferation | 24615654 |
| Hgene | THBS1 | GO:0050921 | positive regulation of chemotaxis | 18555217 |
| Hgene | THBS1 | GO:0051592 | response to calcium ion | 6777381|18757424 |
| Hgene | THBS1 | GO:0051897 | positive regulation of protein kinase B signaling | 18653767 |
| Hgene | THBS1 | GO:0051918 | negative regulation of fibrinolysis | 6438154 |
| Hgene | THBS1 | GO:1902043 | positive regulation of extrinsic apoptotic signaling pathway via death domain receptors | 18726995 |
| Hgene | THBS1 | GO:2000353 | positive regulation of endothelial cell apoptotic process | 18726995 |
| Hgene | THBS1 | GO:2000379 | positive regulation of reactive oxygen species metabolic process | 18757424 |
| Hgene | THBS1 | GO:2001027 | negative regulation of endothelial cell chemotaxis | 16150726 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BG250640 | THBS1 | chr15 | 39885419 | + | ZNF587 | chr19 | 58357351 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000260356 | ENST00000339656 | THBS1 | chr15 | 39885419 | + | ZNF587 | chr19 | 58357351 | + |
| 5CDS-intron | ENST00000260356 | ENST00000423137 | THBS1 | chr15 | 39885419 | + | ZNF587 | chr19 | 58357351 | + |
| 5CDS-intron | ENST00000260356 | ENST00000419854 | THBS1 | chr15 | 39885419 | + | ZNF587 | chr19 | 58357351 | + |
| 5CDS-intron | ENST00000260356 | ENST00000596433 | THBS1 | chr15 | 39885419 | + | ZNF587 | chr19 | 58357351 | + |
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FusionProtFeatures for THBS1_ZNF587 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| THBS1 | ZNF587 |