|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 37916 |
FusionGeneSummary for TGFBRAP1_ARHGAP15 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TGFBRAP1_ARHGAP15 | Fusion gene ID: 37916 | Hgene | Tgene | Gene symbol | TGFBRAP1 | ARHGAP15 | Gene ID | 9392 | 55843 |
| Gene name | transforming growth factor beta receptor associated protein 1 | Rho GTPase activating protein 15 | |
| Synonyms | TRAP-1|TRAP1|VPS3 | BM046 | |
| Cytomap | 2q12.1-q12.2 | 2q22.2-q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transforming growth factor-beta receptor-associated protein 1TGF-beta receptor-associated protein 1VPS3 CORVET complex subunit | rho GTPase-activating protein 15rho-type GTPase-activating protein 15 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8WUH2 | Q53QZ3 | |
| Ensembl transtripts involved in fusion gene | ENST00000393359, ENST00000258449, | ENST00000409869, ENST00000295095, ENST00000473426, | |
| Fusion gene scores | * DoF score | 4 X 3 X 3=36 | 9 X 8 X 5=360 |
| # samples | 4 | 9 | |
| ** MAII score | log2(4/36*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TGFBRAP1 [Title/Abstract] AND ARHGAP15 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TGFBRAP1 | GO:0006355 | regulation of transcription, DNA-templated | 11278302 |
| Hgene | TGFBRAP1 | GO:0007165 | signal transduction | 11278302 |
| Tgene | ARHGAP15 | GO:0008360 | regulation of cell shape | 12650940 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-AB2O-01A | TGFBRAP1 | chr2 | 105885729 | - | ARHGAP15 | chr2 | 144193170 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000393359 | ENST00000409869 | TGFBRAP1 | chr2 | 105885729 | - | ARHGAP15 | chr2 | 144193170 | + |
| 5CDS-intron | ENST00000393359 | ENST00000295095 | TGFBRAP1 | chr2 | 105885729 | - | ARHGAP15 | chr2 | 144193170 | + |
| 5CDS-intron | ENST00000393359 | ENST00000473426 | TGFBRAP1 | chr2 | 105885729 | - | ARHGAP15 | chr2 | 144193170 | + |
| 5CDS-intron | ENST00000258449 | ENST00000409869 | TGFBRAP1 | chr2 | 105885729 | - | ARHGAP15 | chr2 | 144193170 | + |
| 5CDS-intron | ENST00000258449 | ENST00000295095 | TGFBRAP1 | chr2 | 105885729 | - | ARHGAP15 | chr2 | 144193170 | + |
| 5CDS-intron | ENST00000258449 | ENST00000473426 | TGFBRAP1 | chr2 | 105885729 | - | ARHGAP15 | chr2 | 144193170 | + |
Top |
FusionProtFeatures for TGFBRAP1_ARHGAP15 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TGFBRAP1 | ARHGAP15 |