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Fusion gene ID: 37894 |
FusionGeneSummary for TGFBI_ANXA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TGFBI_ANXA1 | Fusion gene ID: 37894 | Hgene | Tgene | Gene symbol | TGFBI | ANXA1 | Gene ID | 7045 | 301 |
| Gene name | transforming growth factor beta induced | annexin A1 | |
| Synonyms | BIGH3|CDB1|CDG2|CDGG1|CSD|CSD1|CSD2|CSD3|EBMD|LCD1 | ANX1|LPC1 | |
| Cytomap | 5q31.1 | 9q21.13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transforming growth factor-beta-induced protein ig-h3RGD-CAPRGD-containing collagen-associated proteinbeta ig-h3betaig-h3kerato-epithelintransforming growth factor beta-induced 68kDatransforming growth factor, beta-induced, 68kD | annexin A1annexin I (lipocortin I)annexin-1calpactin IIcalpactin-2chromobindin-9phospholipase A2 inhibitory protein | |
| Modification date | 20180527 | 20180522 | |
| UniProtAcc | Q15582 | P04083 | |
| Ensembl transtripts involved in fusion gene | ENST00000442011, ENST00000305126, ENST00000508076, ENST00000504185, | ENST00000257497, ENST00000376911, ENST00000491192, | |
| Fusion gene scores | * DoF score | 9 X 8 X 4=288 | 19 X 2 X 7=266 |
| # samples | 10 | 19 | |
| ** MAII score | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(19/266*10)=-0.485426827170242 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TGFBI [Title/Abstract] AND ANXA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ANXA1 | GO:0002548 | monocyte chemotaxis | 15187149 |
| Tgene | ANXA1 | GO:0007187 | G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | 25664854 |
| Tgene | ANXA1 | GO:0008360 | regulation of cell shape | 15187149 |
| Tgene | ANXA1 | GO:0018149 | peptide cross-linking | 10908733 |
| Tgene | ANXA1 | GO:0030216 | keratinocyte differentiation | 10908733 |
| Tgene | ANXA1 | GO:0031340 | positive regulation of vesicle fusion | 2138016 |
| Tgene | ANXA1 | GO:0031532 | actin cytoskeleton reorganization | 15187149 |
| Tgene | ANXA1 | GO:0032743 | positive regulation of interleukin-2 production | 17008549 |
| Tgene | ANXA1 | GO:0035924 | cellular response to vascular endothelial growth factor stimulus | 22773844 |
| Tgene | ANXA1 | GO:0042102 | positive regulation of T cell proliferation | 17008549 |
| Tgene | ANXA1 | GO:0045627 | positive regulation of T-helper 1 cell differentiation | 17008549 |
| Tgene | ANXA1 | GO:0045629 | negative regulation of T-helper 2 cell differentiation | 17008549 |
| Tgene | ANXA1 | GO:0071385 | cellular response to glucocorticoid stimulus | 2936963 |
| Tgene | ANXA1 | GO:0071621 | granulocyte chemotaxis | 15187149 |
| Tgene | ANXA1 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis | 22773844 |
| Tgene | ANXA1 | GO:0090303 | positive regulation of wound healing | 25664854 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | CESC | TCGA-ZJ-AAXN-01A | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000442011 | ENST00000257497 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| 5CDS-intron | ENST00000442011 | ENST00000376911 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| 5CDS-intron | ENST00000442011 | ENST00000491192 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| 5CDS-intron | ENST00000305126 | ENST00000257497 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| 5CDS-intron | ENST00000305126 | ENST00000376911 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| 5CDS-intron | ENST00000305126 | ENST00000491192 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| 5CDS-intron | ENST00000508076 | ENST00000257497 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| 5CDS-intron | ENST00000508076 | ENST00000376911 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| 5CDS-intron | ENST00000508076 | ENST00000491192 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| intron-intron | ENST00000504185 | ENST00000257497 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| intron-intron | ENST00000504185 | ENST00000376911 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
| intron-intron | ENST00000504185 | ENST00000491192 | TGFBI | chr5 | 135399504 | + | ANXA1 | chr9 | 75772570 | + |
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FusionProtFeatures for TGFBI_ANXA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TGFBI | ANXA1 |