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Fusion gene ID: 37877 |
FusionGeneSummary for TF_HMGCS2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TF_HMGCS2 | Fusion gene ID: 37877 | Hgene | Tgene | Gene symbol | TF | HMGCS2 | Gene ID | 7018 | 3158 |
| Gene name | transferrin | 3-hydroxy-3-methylglutaryl-CoA synthase 2 | |
| Synonyms | HEL-S-71p|PRO1557|PRO2086|TFQTL1 | - | |
| Cytomap | 3q22.1 | 1p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serotransferrinbeta-1 metal-binding globulinepididymis secretory sperm binding protein Li 71psiderophilin | hydroxymethylglutaryl-CoA synthase, mitochondrial3-hydroxy-3-methylglutaryl-CoA synthase 2 (mitochondrial)3-hydroxy-3-methylglutaryl-Coenzyme A synthase 2 (mitochondrial)HMG-CoA synthasetesticular tissue protein Li 88 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P02787 | P54868 | |
| Ensembl transtripts involved in fusion gene | ENST00000402696, ENST00000264998, ENST00000475382, | ENST00000369406, ENST00000544913, ENST00000476640, | |
| Fusion gene scores | * DoF score | 13 X 9 X 2=234 | 3 X 3 X 2=18 |
| # samples | 17 | 3 | |
| ** MAII score | log2(17/234*10)=-0.460973783445703 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TF [Title/Abstract] AND HMGCS2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TF | GO:0048260 | positive regulation of receptor-mediated endocytosis | 12704209 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LIHC | TCGA-DD-A73C-01A | TF | chr3 | 133473515 | + | HMGCS2 | chr1 | 120293531 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000402696 | ENST00000369406 | TF | chr3 | 133473515 | + | HMGCS2 | chr1 | 120293531 | - |
| Frame-shift | ENST00000402696 | ENST00000544913 | TF | chr3 | 133473515 | + | HMGCS2 | chr1 | 120293531 | - |
| 5CDS-intron | ENST00000402696 | ENST00000476640 | TF | chr3 | 133473515 | + | HMGCS2 | chr1 | 120293531 | - |
| Frame-shift | ENST00000264998 | ENST00000369406 | TF | chr3 | 133473515 | + | HMGCS2 | chr1 | 120293531 | - |
| Frame-shift | ENST00000264998 | ENST00000544913 | TF | chr3 | 133473515 | + | HMGCS2 | chr1 | 120293531 | - |
| 5CDS-intron | ENST00000264998 | ENST00000476640 | TF | chr3 | 133473515 | + | HMGCS2 | chr1 | 120293531 | - |
| intron-3CDS | ENST00000475382 | ENST00000369406 | TF | chr3 | 133473515 | + | HMGCS2 | chr1 | 120293531 | - |
| intron-3CDS | ENST00000475382 | ENST00000544913 | TF | chr3 | 133473515 | + | HMGCS2 | chr1 | 120293531 | - |
| intron-intron | ENST00000475382 | ENST00000476640 | TF | chr3 | 133473515 | + | HMGCS2 | chr1 | 120293531 | - |
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FusionProtFeatures for TF_HMGCS2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TF | HMGCS2 |