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Fusion gene ID: 37799 |
FusionGeneSummary for TEX2_POLG2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TEX2_POLG2 | Fusion gene ID: 37799 | Hgene | Tgene | Gene symbol | TEX2 | POLG2 | Gene ID | 55852 | 11232 |
| Gene name | testis expressed 2 | DNA polymerase gamma 2, accessory subunit | |
| Synonyms | HT008|TMEM96 | HP55|MTPOLB|PEOA4|POLB|POLG-BETA|POLGB | |
| Cytomap | 17q23.3 | 17q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | testis-expressed protein 2testis expressed sequence 2testis-expressed sequence 2 proteintransmembrane protein 96 | DNA polymerase subunit gamma-2, mitochondrialDNA polymerase gamma accessory 55 kDa subunitmitochondrial DNA polymerase subunit gamma-2mitochondrial DNA polymerase, accessory subunitp55polymerase (DNA directed), gamma 2, accessory subunitpolymerase ( | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8IWB9 | Q9UHN1 | |
| Ensembl transtripts involved in fusion gene | ENST00000258991, ENST00000583097, ENST00000584379, ENST00000581812, | ENST00000539111, ENST00000582501, | |
| Fusion gene scores | * DoF score | 11 X 5 X 6=330 | 1 X 1 X 1=1 |
| # samples | 11 | 1 | |
| ** MAII score | log2(11/330*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TEX2 [Title/Abstract] AND POLG2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-29-1781-01A | TEX2 | chr17 | 62289934 | - | POLG2 | chr17 | 62481985 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000258991 | ENST00000539111 | TEX2 | chr17 | 62289934 | - | POLG2 | chr17 | 62481985 | - |
| 5CDS-5UTR | ENST00000258991 | ENST00000582501 | TEX2 | chr17 | 62289934 | - | POLG2 | chr17 | 62481985 | - |
| Frame-shift | ENST00000583097 | ENST00000539111 | TEX2 | chr17 | 62289934 | - | POLG2 | chr17 | 62481985 | - |
| 5CDS-5UTR | ENST00000583097 | ENST00000582501 | TEX2 | chr17 | 62289934 | - | POLG2 | chr17 | 62481985 | - |
| Frame-shift | ENST00000584379 | ENST00000539111 | TEX2 | chr17 | 62289934 | - | POLG2 | chr17 | 62481985 | - |
| 5CDS-5UTR | ENST00000584379 | ENST00000582501 | TEX2 | chr17 | 62289934 | - | POLG2 | chr17 | 62481985 | - |
| intron-3CDS | ENST00000581812 | ENST00000539111 | TEX2 | chr17 | 62289934 | - | POLG2 | chr17 | 62481985 | - |
| intron-5UTR | ENST00000581812 | ENST00000582501 | TEX2 | chr17 | 62289934 | - | POLG2 | chr17 | 62481985 | - |
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FusionProtFeatures for TEX2_POLG2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TEX2 | POLG2 |