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Fusion gene ID: 37773 |
FusionGeneSummary for TET2_OSTC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TET2_OSTC | Fusion gene ID: 37773 | Hgene | Tgene | Gene symbol | TET2 | OSTC | Gene ID | 54790 | 58505 |
| Gene name | tet methylcytosine dioxygenase 2 | oligosaccharyltransferase complex non-catalytic subunit | |
| Synonyms | KIAA1546|MDS | DC2 | |
| Cytomap | 4q24 | 4q25 | |
| Type of gene | protein-coding | protein-coding | |
| Description | methylcytosine dioxygenase TET2probable methylcytosine dioxygenase TET2tet oncogene family member 2 | oligosaccharyltransferase complex subunit OSTChydrophobic protein HSF-28oligosaccharyltransferase complex subunit (non-catalytic) | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6N021 | Q9NRP0 | |
| Ensembl transtripts involved in fusion gene | ENST00000545826, ENST00000513237, ENST00000540549, ENST00000380013, ENST00000305737, ENST00000394764, ENST00000504042, ENST00000413648, | ENST00000361564, ENST00000512478, ENST00000505745, | |
| Fusion gene scores | * DoF score | 6 X 4 X 6=144 | 1 X 1 X 1=1 |
| # samples | 7 | 1 | |
| ** MAII score | log2(7/144*10)=-1.04064198449735 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TET2 [Title/Abstract] AND OSTC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TET2 | GO:0006211 | 5-methylcytosine catabolic process | 24315485 |
| Hgene | TET2 | GO:0006493 | protein O-linked glycosylation | 23222540 |
| Hgene | TET2 | GO:0080111 | DNA demethylation | 24315485 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | KIRC | TCGA-BP-4770-01A | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000545826 | ENST00000361564 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-3CDS | ENST00000545826 | ENST00000512478 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-intron | ENST00000545826 | ENST00000505745 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-3CDS | ENST00000513237 | ENST00000361564 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-3CDS | ENST00000513237 | ENST00000512478 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-intron | ENST00000513237 | ENST00000505745 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-3CDS | ENST00000540549 | ENST00000361564 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-3CDS | ENST00000540549 | ENST00000512478 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-intron | ENST00000540549 | ENST00000505745 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 5UTR-3CDS | ENST00000380013 | ENST00000361564 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 5UTR-3CDS | ENST00000380013 | ENST00000512478 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 5UTR-intron | ENST00000380013 | ENST00000505745 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 5UTR-3CDS | ENST00000305737 | ENST00000361564 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 5UTR-3CDS | ENST00000305737 | ENST00000512478 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 5UTR-intron | ENST00000305737 | ENST00000505745 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 5UTR-3CDS | ENST00000394764 | ENST00000361564 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 5UTR-3CDS | ENST00000394764 | ENST00000512478 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 5UTR-intron | ENST00000394764 | ENST00000505745 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 3UTR-3CDS | ENST00000504042 | ENST00000361564 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 3UTR-3CDS | ENST00000504042 | ENST00000512478 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| 3UTR-intron | ENST00000504042 | ENST00000505745 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-3CDS | ENST00000413648 | ENST00000361564 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-3CDS | ENST00000413648 | ENST00000512478 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
| intron-intron | ENST00000413648 | ENST00000505745 | TET2 | chr4 | 106111662 | + | OSTC | chr4 | 109588403 | + |
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FusionProtFeatures for TET2_OSTC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TET2 | OSTC |