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Fusion gene ID: 3768 |
FusionGeneSummary for BABAM1_MALAT1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BABAM1_MALAT1 | Fusion gene ID: 3768 | Hgene | Tgene | Gene symbol | BABAM1 | MALAT1 | Gene ID | 29086 | 378938 |
| Gene name | BRISC and BRCA1 A complex member 1 | metastasis associated lung adenocarcinoma transcript 1 | |
| Synonyms | C19orf62|HSPC142|MERIT40|NBA1 | HCN|LINC00047|NCRNA00047|NEAT2|PRO2853 | |
| Cytomap | 19p13.11 | 11q13.1 | |
| Type of gene | protein-coding | ncRNA | |
| Description | BRISC and BRCA1-A complex member 1BRCA1-A complex subunit MERIT40mediator of RAP80 interactions and targeting subunit of 40 kDamediator of Rap80 interactions and targeting 40 kDanew component of the BRCA1-A complexnew component of the BRCAA1 A comple | hepcarcinlong intergenic non-protein coding RNA 47metastasis associated lung adenocarcinoma transcript 1 (non-protein coding)nuclear enriched abundant transcript 2nuclear paraspeckle assembly transcript 2 (non-protein coding) | |
| Modification date | 20180522 | 20180527 | |
| UniProtAcc | Q9NWV8 | ||
| Ensembl transtripts involved in fusion gene | ENST00000598188, ENST00000359435, ENST00000447614, ENST00000601043, ENST00000448635, ENST00000595632, | ENST00000534336, | |
| Fusion gene scores | * DoF score | 1 X 1 X 1=1 | 71 X 110 X 1=7810 |
| # samples | 3 | 126 | |
| ** MAII score | log2(3/1*10)=4.90689059560852 | log2(126/7810*10)=-2.63189881464206 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BABAM1 [Title/Abstract] AND MALAT1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | DW420833 | BABAM1 | chr19 | 17378339 | + | MALAT1 | chr11 | 65266978 | + | ||
| ChiTaRS3.1 | DW412002 | BABAM1 | chr19 | 17378339 | + | MALAT1 | chr11 | 65266978 | + | ||
| ChiTaRS3.1 | DW413863 | BABAM1 | chr19 | 17378339 | + | MALAT1 | chr11 | 65266978 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3UTR | ENST00000598188 | ENST00000534336 | BABAM1 | chr19 | 17378339 | + | MALAT1 | chr11 | 65266978 | + |
| 5UTR-3UTR | ENST00000359435 | ENST00000534336 | BABAM1 | chr19 | 17378339 | + | MALAT1 | chr11 | 65266978 | + |
| 5UTR-3UTR | ENST00000447614 | ENST00000534336 | BABAM1 | chr19 | 17378339 | + | MALAT1 | chr11 | 65266978 | + |
| intron-3UTR | ENST00000601043 | ENST00000534336 | BABAM1 | chr19 | 17378339 | + | MALAT1 | chr11 | 65266978 | + |
| 3UTR-3UTR | ENST00000448635 | ENST00000534336 | BABAM1 | chr19 | 17378339 | + | MALAT1 | chr11 | 65266978 | + |
| 5UTR-3UTR | ENST00000595632 | ENST00000534336 | BABAM1 | chr19 | 17378339 | + | MALAT1 | chr11 | 65266978 | + |
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FusionProtFeatures for BABAM1_MALAT1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BABAM1 | MALAT1 |