|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 3765 |
FusionGeneSummary for BAALC_UBR5 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: BAALC_UBR5 | Fusion gene ID: 3765 | Hgene | Tgene | Gene symbol | BAALC | UBR5 | Gene ID | 79870 | 51366 |
| Gene name | BAALC, MAP3K1 and KLF4 binding | ubiquitin protein ligase E3 component n-recognin 5 | |
| Synonyms | - | DD5|EDD|EDD1|HYD | |
| Cytomap | 8q22.3 | 8q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | brain and acute leukemia cytoplasmic proteinBAALC, MEKK1 and KLF4 bindingbrain and acute leukemia, cytoplasmic | E3 ubiquitin-protein ligase UBR5E3 identified by differential displayE3 ubiquitin-protein ligase, HECT domain-containing 1HECT-type E3 ubiquitin transferase UBR5hyperplastic discs protein homologprogestin-induced protein | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q8WXS3 | O95071 | |
| Ensembl transtripts involved in fusion gene | ENST00000309982, ENST00000438105, ENST00000297574, ENST00000330955, ENST00000306391, ENST00000523754, | ENST00000520539, ENST00000220959, ENST00000518205, ENST00000521922, ENST00000519528, | |
| Fusion gene scores | * DoF score | 3 X 2 X 3=18 | 8 X 13 X 6=624 |
| # samples | 3 | 14 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(14/624*10)=-2.15611920191728 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: BAALC [Title/Abstract] AND UBR5 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | UBR5 | GO:0000209 | protein polyubiquitination | 21118991|28689657 |
| Tgene | UBR5 | GO:0006974 | cellular response to DNA damage stimulus | 12011095 |
| Tgene | UBR5 | GO:0010628 | positive regulation of gene expression | 18076571 |
| Tgene | UBR5 | GO:0050847 | progesterone receptor signaling pathway | 12011095 |
| Tgene | UBR5 | GO:0070936 | protein K48-linked ubiquitination | 28689657 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-FR-A2OS-01A | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000309982 | ENST00000520539 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| Frame-shift | ENST00000309982 | ENST00000220959 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-5UTR | ENST00000309982 | ENST00000518205 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-5UTR | ENST00000309982 | ENST00000521922 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-intron | ENST00000309982 | ENST00000519528 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| Frame-shift | ENST00000438105 | ENST00000520539 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| Frame-shift | ENST00000438105 | ENST00000220959 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-5UTR | ENST00000438105 | ENST00000518205 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-5UTR | ENST00000438105 | ENST00000521922 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-intron | ENST00000438105 | ENST00000519528 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| Frame-shift | ENST00000297574 | ENST00000520539 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| Frame-shift | ENST00000297574 | ENST00000220959 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-5UTR | ENST00000297574 | ENST00000518205 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-5UTR | ENST00000297574 | ENST00000521922 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-intron | ENST00000297574 | ENST00000519528 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| Frame-shift | ENST00000330955 | ENST00000520539 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| Frame-shift | ENST00000330955 | ENST00000220959 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-5UTR | ENST00000330955 | ENST00000518205 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-5UTR | ENST00000330955 | ENST00000521922 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-intron | ENST00000330955 | ENST00000519528 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| Frame-shift | ENST00000306391 | ENST00000520539 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| Frame-shift | ENST00000306391 | ENST00000220959 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-5UTR | ENST00000306391 | ENST00000518205 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-5UTR | ENST00000306391 | ENST00000521922 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| 5CDS-intron | ENST00000306391 | ENST00000519528 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| intron-3CDS | ENST00000523754 | ENST00000520539 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| intron-3CDS | ENST00000523754 | ENST00000220959 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| intron-5UTR | ENST00000523754 | ENST00000518205 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| intron-5UTR | ENST00000523754 | ENST00000521922 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
| intron-intron | ENST00000523754 | ENST00000519528 | BAALC | chr8 | 104153285 | + | UBR5 | chr8 | 103285000 | - |
Top |
FusionProtFeatures for BAALC_UBR5 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| BAALC | UBR5 |