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Fusion gene ID: 37611 |
FusionGeneSummary for TCF7_S100A14 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCF7_S100A14 | Fusion gene ID: 37611 | Hgene | Tgene | Gene symbol | TCF7 | S100A14 | Gene ID | 6932 | 57402 |
| Gene name | transcription factor 7 | S100 calcium binding protein A14 | |
| Synonyms | TCF-1 | BCMP84|S100A15 | |
| Cytomap | 5q31.1 | 1q21.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor 7T-cell-factor-7T-cell-specific transcription factor 1transcription factor 7 (T-cell specific, HMG-box) | protein S100-A14S114breast cancer membrane protein 84 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P36402 | Q9HCY8 | |
| Ensembl transtripts involved in fusion gene | ENST00000378564, ENST00000321584, ENST00000321603, ENST00000342854, ENST00000395029, ENST00000432532, ENST00000378560, ENST00000520958, ENST00000518915, ENST00000395023, ENST00000517478, | ENST00000476873, ENST00000368701, ENST00000368702, ENST00000344616, ENST00000368700, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 3 X 3 X 1=9 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(3/9*10)=1.73696559416621 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TCF7 [Title/Abstract] AND S100A14 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TCF7 | GO:0071353 | cellular response to interleukin-4 | 18579517 |
| Tgene | S100A14 | GO:0034142 | toll-like receptor 4 signaling pathway | 17625598 |
| Tgene | S100A14 | GO:0071624 | positive regulation of granulocyte chemotaxis | 18606705 |
| Tgene | S100A14 | GO:0090026 | positive regulation of monocyte chemotaxis | 18606705 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF799331 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000378564 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378564 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378564 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378564 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000378564 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321584 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321584 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321584 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321584 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000321584 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321603 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321603 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321603 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000321603 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000321603 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000342854 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000342854 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000342854 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000342854 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000342854 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395029 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395029 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395029 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395029 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000395029 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000432532 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000432532 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000432532 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000432532 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000432532 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378560 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378560 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378560 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000378560 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000378560 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000520958 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000520958 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000520958 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000520958 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000520958 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000518915 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000518915 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000518915 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000518915 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000518915 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395023 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395023 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395023 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-3UTR | ENST00000395023 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| 5CDS-5UTR | ENST00000395023 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| intron-3UTR | ENST00000517478 | ENST00000476873 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| intron-3UTR | ENST00000517478 | ENST00000368701 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| intron-3UTR | ENST00000517478 | ENST00000368702 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| intron-3UTR | ENST00000517478 | ENST00000344616 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
| intron-5UTR | ENST00000517478 | ENST00000368700 | TCF7 | chr5 | 133451685 | + | S100A14 | chr1 | 153587333 | + |
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FusionProtFeatures for TCF7_S100A14 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCF7 | S100A14 |