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Fusion gene ID: 37610 |
FusionGeneSummary for TCF7_MTPAP |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCF7_MTPAP | Fusion gene ID: 37610 | Hgene | Tgene | Gene symbol | TCF7 | MTPAP | Gene ID | 6932 | 55149 |
| Gene name | transcription factor 7 | mitochondrial poly(A) polymerase | |
| Synonyms | TCF-1 | PAPD1|SPAX4|TENT6 | |
| Cytomap | 5q31.1 | 10p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor 7T-cell-factor-7T-cell-specific transcription factor 1transcription factor 7 (T-cell specific, HMG-box) | poly(A) RNA polymerase, mitochondrialPAP-associated domain-containing protein 1TUTase 1polynucleotide adenylyltransferaseterminal uridylyltransferase 1 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P36402 | Q9NVV4 | |
| Ensembl transtripts involved in fusion gene | ENST00000378564, ENST00000321584, ENST00000321603, ENST00000342854, ENST00000395029, ENST00000432532, ENST00000378560, ENST00000520958, ENST00000518915, ENST00000395023, ENST00000517478, | ENST00000263063, ENST00000358107, ENST00000488290, | |
| Fusion gene scores | * DoF score | 4 X 4 X 1=16 | 2 X 2 X 2=8 |
| # samples | 4 | 2 | |
| ** MAII score | log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TCF7 [Title/Abstract] AND MTPAP [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TCF7 | GO:0071353 | cellular response to interleukin-4 | 18579517 |
| Tgene | MTPAP | GO:0006378 | mRNA polyadenylation | 21292163 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CN411934 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000378564 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000378564 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-intron | ENST00000378564 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000321584 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000321584 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-intron | ENST00000321584 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000321603 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000321603 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-intron | ENST00000321603 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-3UTR | ENST00000342854 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-3UTR | ENST00000342854 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-intron | ENST00000342854 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-3UTR | ENST00000395029 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-3UTR | ENST00000395029 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-intron | ENST00000395029 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000432532 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000432532 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-intron | ENST00000432532 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-3UTR | ENST00000378560 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-3UTR | ENST00000378560 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-intron | ENST00000378560 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000520958 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000520958 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-intron | ENST00000520958 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000518915 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000518915 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-intron | ENST00000518915 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-3UTR | ENST00000395023 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-3UTR | ENST00000395023 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| 3UTR-intron | ENST00000395023 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000517478 | ENST00000263063 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-3UTR | ENST00000517478 | ENST00000358107 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
| intron-intron | ENST00000517478 | ENST00000488290 | TCF7 | chr5 | 133482975 | + | MTPAP | chr10 | 30599325 | - |
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FusionProtFeatures for TCF7_MTPAP |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCF7 | MTPAP |