	FusionGeneSummary
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Fusion gene ID: 37606

FusionGeneSummary for TCF7L2_PTPRC

Fusion gene summary

Fusion gene information	Fusion gene name: TCF7L2_PTPRC
	Fusion gene ID: 37606
		Hgene	Tgene
	Gene symbol	TCF7L2	PTPRC
	Gene ID	6934	5788
	Gene name	transcription factor 7 like 2	protein tyrosine phosphatase, receptor type C
	Synonyms	TCF-4\|TCF4	B220\|CD45\|CD45R\|GP180\|L-CA\|LCA\|LY5\|T200
	Cytomap	10q25.2-q25.3	1q31.3-q32.1
	Type of gene	protein-coding	protein-coding
	Description	transcription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box)	receptor-type tyrosine-protein phosphatase CCD45 antigenT200 glycoproteinT200 leukocyte common antigenprotein tyrosine phosphatase, receptor type, c polypeptide
	Modification date	20180527	20180522
	UniProtAcc	Q9NQB0	P08575
	Ensembl transtripts involved in fusion gene	ENST00000534894, ENST00000536810, ENST00000545257, ENST00000355995, ENST00000543371, ENST00000355717, ENST00000538897, ENST00000349937, ENST00000369397, ENST00000352065, ENST00000369395, ENST00000542695, ENST00000369389, ENST00000369386, ENST00000466338,	ENST00000352140, ENST00000594404, ENST00000367376, ENST00000442510, ENST00000348564, ENST00000598951, ENST00000367364, ENST00000413409, ENST00000391970,
Fusion gene scores	* DoF score	9 X 7 X 10=630	4 X 4 X 2=32
	# samples	15	5
	** MAII score	log2(15/630*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/32*10)=0.643856189774725 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TCF7L2 [Title/Abstract] AND PTPRC [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TCF7L2	GO:0000122	negative regulation of transcription by RNA polymerase II	12799378
Hgene	TCF7L2	GO:0006357	regulation of transcription by RNA polymerase II	9727977
Hgene	TCF7L2	GO:0032092	positive regulation of protein binding	12799378
Hgene	TCF7L2	GO:0032350	regulation of hormone metabolic process	15525634
Hgene	TCF7L2	GO:0042593	glucose homeostasis	15525634
Hgene	TCF7L2	GO:0043433	negative regulation of DNA binding transcription factor activity	12799378
Hgene	TCF7L2	GO:0045444	fat cell differentiation	10937998
Hgene	TCF7L2	GO:0045892	negative regulation of transcription, DNA-templated	12799378\|15525634
Hgene	TCF7L2	GO:0045944	positive regulation of transcription by RNA polymerase II	9065401\|19168596
Hgene	TCF7L2	GO:0048625	myoblast fate commitment	10937998
Tgene	PTPRC	GO:0006469	negative regulation of protein kinase activity	9197241
Tgene	PTPRC	GO:0050852	T cell receptor signaling pathway	10358156

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF910208	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
ChiTaRS3.1			BF910138	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
intron-intron	ENST00000534894	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000534894	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000534894	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000534894	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000534894	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000534894	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000534894	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000534894	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000534894	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000536810	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000536810	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000536810	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000536810	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000536810	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000536810	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000536810	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000536810	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000536810	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000545257	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000545257	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000545257	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000545257	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000545257	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000545257	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000545257	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000545257	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000545257	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355995	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355995	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355995	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355995	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355995	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355995	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355995	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355995	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355995	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000543371	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000543371	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000543371	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000543371	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000543371	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000543371	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000543371	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000543371	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000543371	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355717	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355717	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355717	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355717	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355717	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355717	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355717	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355717	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000355717	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000538897	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000538897	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000538897	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000538897	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000538897	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000538897	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000538897	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000538897	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000538897	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000349937	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000349937	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000349937	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000349937	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000349937	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000349937	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000349937	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000349937	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000349937	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369397	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369397	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369397	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369397	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369397	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369397	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369397	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369397	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369397	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000352065	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000352065	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000352065	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000352065	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000352065	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000352065	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000352065	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000352065	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000352065	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369395	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369395	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369395	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369395	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369395	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369395	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369395	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369395	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369395	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000542695	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000542695	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000542695	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000542695	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000542695	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000542695	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000542695	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000542695	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000542695	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369389	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369389	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369389	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369389	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369389	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369389	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369389	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369389	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369389	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369386	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369386	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369386	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369386	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369386	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369386	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369386	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369386	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000369386	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000466338	ENST00000352140	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000466338	ENST00000594404	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000466338	ENST00000367376	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000466338	ENST00000442510	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000466338	ENST00000348564	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000466338	ENST00000598951	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000466338	ENST00000367364	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000466338	ENST00000413409	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-
intron-intron	ENST00000466338	ENST00000391970	TCF7L2	chr10	114823655	-	PTPRC	chr1	198665721	-

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FusionProtFeatures for TCF7L2_PTPRC

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TCF7L2 Q9NQB0	PTPRC P08575

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Fusion gene ID: 37606

FusionGeneSummary for TCF7L2_PTPRC

FusionProtFeatures for TCF7L2_PTPRC