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Fusion gene ID: 37605 |
FusionGeneSummary for TCF7L2_MAML3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCF7L2_MAML3 | Fusion gene ID: 37605 | Hgene | Tgene | Gene symbol | TCF7L2 | MAML3 | Gene ID | 6934 | 55534 |
| Gene name | transcription factor 7 like 2 | mastermind like transcriptional coactivator 3 | |
| Synonyms | TCF-4|TCF4 | CAGH3|ERDA3|GDN|MAM-2|MAM2|TNRC3|mam-3 | |
| Cytomap | 10q25.2-q25.3 | 4q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor 7-like 2HMG box transcription factor 4T-cell factor 4T-cell-specific transcription factor 4hTCF-4transcription factor 7-like 2 (T-cell specific, HMG-box) | mastermind-like protein 3CAG repeat containing (glia-derived nexin I alpha)expanded repeat domain, CAG/CTG 3polyglutamine richtrinucleotide repeat containing 3 | |
| Modification date | 20180527 | 20180524 | |
| UniProtAcc | Q9NQB0 | Q96JK9 | |
| Ensembl transtripts involved in fusion gene | ENST00000534894, ENST00000536810, ENST00000545257, ENST00000355995, ENST00000543371, ENST00000355717, ENST00000538897, ENST00000349937, ENST00000369397, ENST00000352065, ENST00000369395, ENST00000542695, ENST00000369389, ENST00000369386, ENST00000466338, | ENST00000509479, ENST00000327122, ENST00000398940, | |
| Fusion gene scores | * DoF score | 9 X 7 X 10=630 | 7 X 4 X 4=112 |
| # samples | 15 | 14 | |
| ** MAII score | log2(15/630*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/112*10)=0.321928094887362 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TCF7L2 [Title/Abstract] AND MAML3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TCF7L2 | GO:0000122 | negative regulation of transcription by RNA polymerase II | 12799378 |
| Hgene | TCF7L2 | GO:0006357 | regulation of transcription by RNA polymerase II | 9727977 |
| Hgene | TCF7L2 | GO:0032092 | positive regulation of protein binding | 12799378 |
| Hgene | TCF7L2 | GO:0032350 | regulation of hormone metabolic process | 15525634 |
| Hgene | TCF7L2 | GO:0042593 | glucose homeostasis | 15525634 |
| Hgene | TCF7L2 | GO:0043433 | negative regulation of DNA binding transcription factor activity | 12799378 |
| Hgene | TCF7L2 | GO:0045444 | fat cell differentiation | 10937998 |
| Hgene | TCF7L2 | GO:0045892 | negative regulation of transcription, DNA-templated | 12799378|15525634 |
| Hgene | TCF7L2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 9065401|19168596 |
| Hgene | TCF7L2 | GO:0048625 | myoblast fate commitment | 10937998 |
| Tgene | MAML3 | GO:0007219 | Notch signaling pathway | 12370315 |
| Tgene | MAML3 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12370315 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | PCPG | TCGA-WB-A80Y-01A | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000534894 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000534894 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000534894 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000536810 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000536810 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000536810 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000545257 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000545257 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000545257 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000355995 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000355995 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000355995 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000543371 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000543371 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000543371 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000355717 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000355717 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000355717 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000538897 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000538897 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000538897 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000349937 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000349937 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000349937 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000369397 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000369397 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000369397 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000352065 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000352065 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000352065 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000369395 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000369395 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000369395 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000542695 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000542695 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000542695 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000369389 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000369389 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000369389 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000369386 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000369386 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000369386 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000466338 | ENST00000509479 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-3CDS | ENST00000466338 | ENST00000327122 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
| intron-intron | ENST00000466338 | ENST00000398940 | TCF7L2 | chr18 | 52921728 | - | MAML3 | chr4 | 140812121 | - |
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FusionProtFeatures for TCF7L2_MAML3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCF7L2 | MAML3 |