|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 37598 |
FusionGeneSummary for TCF7L1_TMEM182 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCF7L1_TMEM182 | Fusion gene ID: 37598 | Hgene | Tgene | Gene symbol | TCF7L1 | TMEM182 | Gene ID | 83439 | 130827 |
| Gene name | transcription factor 7 like 1 | transmembrane protein 182 | |
| Synonyms | TCF-3|TCF3 | - | |
| Cytomap | 2p11.2 | 2q12.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor 7-like 1HMG box transcription factor 3transcription factor 7-like 1 (T-cell specific, HMG-box) | transmembrane protein 182 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q9HCS4 | Q6ZP80 | |
| Ensembl transtripts involved in fusion gene | ENST00000282111, ENST00000494519, | ENST00000409528, ENST00000409173, ENST00000412401, ENST00000486293, | |
| Fusion gene scores | * DoF score | 9 X 5 X 8=360 | 2 X 2 X 2=8 |
| # samples | 9 | 2 | |
| ** MAII score | log2(9/360*10)=-2 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: TCF7L1 [Title/Abstract] AND TMEM182 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-68-8250-01A | TCF7L1 | chr2 | 85510701 | + | TMEM182 | chr2 | 103549343 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-intron | ENST00000282111 | ENST00000409528 | TCF7L1 | chr2 | 85510701 | + | TMEM182 | chr2 | 103549343 | + |
| 5CDS-intron | ENST00000282111 | ENST00000409173 | TCF7L1 | chr2 | 85510701 | + | TMEM182 | chr2 | 103549343 | + |
| 5CDS-intron | ENST00000282111 | ENST00000412401 | TCF7L1 | chr2 | 85510701 | + | TMEM182 | chr2 | 103549343 | + |
| 5CDS-intron | ENST00000282111 | ENST00000486293 | TCF7L1 | chr2 | 85510701 | + | TMEM182 | chr2 | 103549343 | + |
| intron-intron | ENST00000494519 | ENST00000409528 | TCF7L1 | chr2 | 85510701 | + | TMEM182 | chr2 | 103549343 | + |
| intron-intron | ENST00000494519 | ENST00000409173 | TCF7L1 | chr2 | 85510701 | + | TMEM182 | chr2 | 103549343 | + |
| intron-intron | ENST00000494519 | ENST00000412401 | TCF7L1 | chr2 | 85510701 | + | TMEM182 | chr2 | 103549343 | + |
| intron-intron | ENST00000494519 | ENST00000486293 | TCF7L1 | chr2 | 85510701 | + | TMEM182 | chr2 | 103549343 | + |
Top |
FusionProtFeatures for TCF7L1_TMEM182 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCF7L1 | TMEM182 |