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Fusion gene ID: 37564 |
FusionGeneSummary for TCF20_CYP2D6 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCF20_CYP2D6 | Fusion gene ID: 37564 | Hgene | Tgene | Gene symbol | TCF20 | CYP2D6 | Gene ID | 6942 | 1565 |
| Gene name | transcription factor 20 | cytochrome P450 family 2 subfamily D member 6 | |
| Synonyms | AR1|SPBP|TCF-20 | CPD6|CYP2D|CYP2D7AP|CYP2D7BP|CYP2D7P2|CYP2D8P2|CYP2DL1|CYPIID6|P450-DB1|P450C2D|P450DB1 | |
| Cytomap | 22q13.2|22q13.3 | 22q13.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor 20SPRE-binding proteinnuclear factor SPBPstromelysin-1 PDGF-responsive element-binding proteinstromelysin-1 platelet-derived growth factor-responsive element binding protein | cytochrome P450 2D6cholesterol 25-hydroxylasecytochrome P450, family 2, subfamily D, polypeptide 6cytochrome P450, family 2, subfamily D, polypeptide 7 pseudogene 2cytochrome P450, family 2, subfamily D, polypeptide 8 pseudogene 2cytochrome P450, sub | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9UGU0 | P10635 | |
| Ensembl transtripts involved in fusion gene | ENST00000359486, ENST00000335626, ENST00000404876, | ENST00000360608, ENST00000389970, ENST00000359033, | |
| Fusion gene scores | * DoF score | 9 X 4 X 7=252 | 1 X 1 X 1=1 |
| # samples | 12 | 1 | |
| ** MAII score | log2(12/252*10)=-1.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TCF20 [Title/Abstract] AND CYP2D6 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | CYP2D6 | GO:0009804 | coumarin metabolic process | 19438707 |
| Tgene | CYP2D6 | GO:0009820 | alkaloid metabolic process | 19651758 |
| Tgene | CYP2D6 | GO:0009822 | alkaloid catabolic process | 15039299 |
| Tgene | CYP2D6 | GO:0016098 | monoterpenoid metabolic process | 16401082 |
| Tgene | CYP2D6 | GO:0017144 | drug metabolic process | 19219744 |
| Tgene | CYP2D6 | GO:0033076 | isoquinoline alkaloid metabolic process | 19448135 |
| Tgene | CYP2D6 | GO:0042737 | drug catabolic process | 15039299 |
| Tgene | CYP2D6 | GO:0046483 | heterocycle metabolic process | 15327587|19651758 |
| Tgene | CYP2D6 | GO:0051100 | negative regulation of binding | 19448135 |
| Tgene | CYP2D6 | GO:0055114 | oxidation-reduction process | 16401082|19219744 |
| Tgene | CYP2D6 | GO:0070989 | oxidative demethylation | 15039299|19438707 |
| Tgene | CYP2D6 | GO:0090350 | negative regulation of cellular organofluorine metabolic process | 19448135 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-VQ-AA69-01A | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000359486 | ENST00000360608 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000359486 | ENST00000389970 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000359486 | ENST00000359033 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000335626 | ENST00000360608 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000335626 | ENST00000389970 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000335626 | ENST00000359033 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000404876 | ENST00000360608 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000404876 | ENST00000389970 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
| intron-3CDS | ENST00000404876 | ENST00000359033 | TCF20 | chr22 | 42739485 | - | CYP2D6 | chr22 | 42524946 | - |
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FusionProtFeatures for TCF20_CYP2D6 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCF20 | CYP2D6 |