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Fusion gene ID: 37551 |
FusionGeneSummary for TCF12_NIPA1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TCF12_NIPA1 | Fusion gene ID: 37551 | Hgene | Tgene | Gene symbol | TCF12 | NIPA1 | Gene ID | 6938 | 123606 |
| Gene name | transcription factor 12 | NIPA magnesium transporter 1 | |
| Synonyms | CRS3|HEB|HTF4|HsT17266|TCF-12|bHLHb20|p64 | FSP3|SLC57A1|SPG6 | |
| Cytomap | 15q21.3 | 15q11.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription factor 12DNA-binding protein HTF4E-box-binding proteinclass B basic helix-loop-helix protein 20helix-loop-helix transcription factor 4transcription factor HTF-4 | magnesium transporter NIPA1non imprinted in Prader-Willi/Angelman syndrome 1non-imprinted in Prader-Willi/Angelman syndrome region protein 1spastic paraplegia 6 protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q99081 | Q7RTP0 | |
| Ensembl transtripts involved in fusion gene | ENST00000438423, ENST00000267811, ENST00000452095, ENST00000333725, ENST00000557843, ENST00000560764, ENST00000543579, ENST00000537840, ENST00000343827, ENST00000559710, ENST00000559703, | ENST00000337435, ENST00000437912, ENST00000538684, ENST00000561183, | |
| Fusion gene scores | * DoF score | 22 X 12 X 9=2376 | 1 X 1 X 1=1 |
| # samples | 22 | 1 | |
| ** MAII score | log2(22/2376*10)=-3.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TCF12 [Title/Abstract] AND NIPA1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TCF12 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 11802795 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-75-7031-01A | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000438423 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000438423 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000438423 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000438423 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| In-frame | ENST00000267811 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000267811 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000267811 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000267811 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| In-frame | ENST00000452095 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000452095 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000452095 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000452095 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| In-frame | ENST00000333725 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000333725 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000333725 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000333725 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| In-frame | ENST00000557843 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000557843 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000557843 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| 5CDS-5UTR | ENST00000557843 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-3CDS | ENST00000560764 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000560764 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000560764 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000560764 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-3CDS | ENST00000543579 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000543579 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000543579 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000543579 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-3CDS | ENST00000537840 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000537840 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000537840 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000537840 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-3CDS | ENST00000343827 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000343827 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000343827 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000343827 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-3CDS | ENST00000559710 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000559710 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000559710 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000559710 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-3CDS | ENST00000559703 | ENST00000337435 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000559703 | ENST00000437912 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000559703 | ENST00000538684 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
| intron-5UTR | ENST00000559703 | ENST00000561183 | TCF12 | chr15 | 57213296 | + | NIPA1 | chr15 | 23062319 | + |
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FusionProtFeatures for TCF12_NIPA1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TCF12 | NIPA1 |