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Fusion gene ID: 37441

FusionGeneSummary for TBCD_ASPSCR1

Fusion gene summary

Fusion gene information	Fusion gene name: TBCD_ASPSCR1
	Fusion gene ID: 37441
		Hgene	Tgene
	Gene symbol	TBCD	ASPSCR1
	Gene ID	6904	79058
	Gene name	tubulin folding cofactor D	ASPSCR1, UBX domain containing tether for SLC2A4
	Synonyms	PEBAT\|SSD-1\|tfcD	ASPCR1\|ASPL\|ASPS\|RCC17\|TUG\|UBXD9\|UBXN9
	Cytomap	17q25.3	17q25.3
	Type of gene	protein-coding	protein-coding
	Description	tubulin-specific chaperone Dbeta-tubulin cofactor D	tether containing UBX domain for GLUT4UBX domain protein 9UBX domain-containing protein 9alveolar soft part sarcoma chromosomal region candidate gene 1 proteinalveolar soft part sarcoma chromosome region, candidate 1alveolar soft part sarcoma locusr
	Modification date	20180523	20180519
	UniProtAcc	Q9BTW9	Q9BZE9
	Ensembl transtripts involved in fusion gene	ENST00000355528, ENST00000397466, ENST00000539345, ENST00000576691,	ENST00000306729, ENST00000306739, ENST00000580534, ENST00000581647, ENST00000582404,
Fusion gene scores	* DoF score	17 X 17 X 11=3179	6 X 5 X 6=180
	# samples	19	6
	** MAII score	log2(19/3179*10)=-4.06450169280703 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(6/180*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: TBCD [Title/Abstract] AND ASPSCR1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation	Oncogene involved fusion gene, in-frame and retained their domain.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TBCD	GO:0006457	protein folding	20740604
Hgene	TBCD	GO:0007021	tubulin complex assembly	28158450
Hgene	TBCD	GO:0007023	post-chaperonin tubulin folding pathway	11847227
Hgene	TBCD	GO:0031115	negative regulation of microtubule polymerization	10831612\|20740604

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	LUSC	TCGA-39-5034-01A	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000355528	ENST00000306729	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
In-frame	ENST00000355528	ENST00000306739	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
In-frame	ENST00000355528	ENST00000580534	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
5CDS-intron	ENST00000355528	ENST00000581647	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
5CDS-intron	ENST00000355528	ENST00000582404	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
5UTR-3CDS	ENST00000397466	ENST00000306729	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
5UTR-3CDS	ENST00000397466	ENST00000306739	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
5UTR-3CDS	ENST00000397466	ENST00000580534	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
5UTR-intron	ENST00000397466	ENST00000581647	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
5UTR-intron	ENST00000397466	ENST00000582404	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
In-frame	ENST00000539345	ENST00000306729	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
In-frame	ENST00000539345	ENST00000306739	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
In-frame	ENST00000539345	ENST00000580534	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
5CDS-intron	ENST00000539345	ENST00000581647	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
5CDS-intron	ENST00000539345	ENST00000582404	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
intron-3CDS	ENST00000576691	ENST00000306729	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
intron-3CDS	ENST00000576691	ENST00000306739	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
intron-3CDS	ENST00000576691	ENST00000580534	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
intron-intron	ENST00000576691	ENST00000581647	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+
intron-intron	ENST00000576691	ENST00000582404	TBCD	chr17	80730383	+	ASPSCR1	chr17	79967362	+

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FusionProtFeatures for TBCD_ASPSCR1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TBCD Q9BTW9	ASPSCR1 Q9BZE9

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Fusion gene ID: 37441

FusionGeneSummary for TBCD_ASPSCR1

FusionProtFeatures for TBCD_ASPSCR1