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Fusion gene ID: 3737 |
FusionGeneSummary for B4GALT2_JAK1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: B4GALT2_JAK1 | Fusion gene ID: 3737 | Hgene | Tgene | Gene symbol | B4GALT2 | JAK1 | Gene ID | 8704 | 3716 |
| Gene name | beta-1,4-galactosyltransferase 2 | Janus kinase 1 | |
| Synonyms | B4Gal-T2|B4Gal-T3|beta4Gal-T2 | JAK1A|JAK1B|JTK3 | |
| Cytomap | 1p34.1 | 1p31.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | beta-1,4-galactosyltransferase 2UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 2UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase 2UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 2UDP-galactose:beta-N-acetylglucosamine beta-1,4-gal | tyrosine-protein kinase JAK1 | |
| Modification date | 20180519 | 20180527 | |
| UniProtAcc | O60909 | P23458 | |
| Ensembl transtripts involved in fusion gene | ENST00000372324, ENST00000434555, ENST00000356836, ENST00000309519, ENST00000481924, | ENST00000342505, ENST00000465376, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 9 X 8 X 4=288 |
| # samples | 2 | 10 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: B4GALT2 [Title/Abstract] AND JAK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | JAK1 | GO:0038110 | interleukin-2-mediated signaling pathway | 11909529 |
| Tgene | JAK1 | GO:0046677 | response to antibiotic | 16280321 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | OV | TCGA-57-1586-01A | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000372324 | ENST00000342505 | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
| 5CDS-intron | ENST00000372324 | ENST00000465376 | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
| 5CDS-5UTR | ENST00000434555 | ENST00000342505 | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
| 5CDS-intron | ENST00000434555 | ENST00000465376 | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
| 5CDS-5UTR | ENST00000356836 | ENST00000342505 | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
| 5CDS-intron | ENST00000356836 | ENST00000465376 | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
| 5CDS-5UTR | ENST00000309519 | ENST00000342505 | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
| 5CDS-intron | ENST00000309519 | ENST00000465376 | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
| intron-5UTR | ENST00000481924 | ENST00000342505 | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
| intron-intron | ENST00000481924 | ENST00000465376 | B4GALT2 | chr1 | 44447596 | + | JAK1 | chr1 | 65352024 | - |
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FusionProtFeatures for B4GALT2_JAK1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| B4GALT2 | JAK1 |