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Fusion gene ID: 3734 |
FusionGeneSummary for B4GALT1_RAF1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: B4GALT1_RAF1 | Fusion gene ID: 3734 | Hgene | Tgene | Gene symbol | B4GALT1 | RAF1 | Gene ID | 2683 | 5894 |
| Gene name | beta-1,4-galactosyltransferase 1 | Raf-1 proto-oncogene, serine/threonine kinase | |
| Synonyms | B4GAL-T1|CDG2D|GGTB2|GT1|GTB|beta4Gal-T1 | CMD1NN|CRAF|NS5|Raf-1|c-Raf | |
| Cytomap | 9p21.1 | 3p25.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | beta-1,4-galactosyltransferase 1UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 1UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1beta-1,4-GalTase 1glycoprotein | RAF proto-oncogene serine/threonine-protein kinaseC-Raf proto-oncogene, serine/threonine kinaseOncogene RAF1proto-oncogene c-RAFraf proto-oncogene serine/threonine protein kinasev-raf-1 murine leukemia viral oncogene homolog 1v-raf-1 murine leukemia | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | P15291 | P04049 | |
| Ensembl transtripts involved in fusion gene | ENST00000535206, ENST00000379731, ENST00000541851, | ENST00000251849, ENST00000442415, ENST00000534997, ENST00000542177, | |
| Fusion gene scores | * DoF score | 9 X 6 X 9=486 | 9 X 4 X 6=216 |
| # samples | 13 | 12 | |
| ** MAII score | log2(13/486*10)=-1.90244469057733 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/216*10)=-0.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: B4GALT1 [Title/Abstract] AND RAF1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | B4GALT1 | GO:0006487 | protein N-linked glycosylation | 16157350 |
| Hgene | B4GALT1 | GO:0009312 | oligosaccharide biosynthetic process | 2120039 |
| Hgene | B4GALT1 | GO:0051260 | protein homooligomerization | 7744867 |
| Tgene | RAF1 | GO:0000186 | activation of MAPKK activity | 10644344 |
| Tgene | RAF1 | GO:0007190 | activation of adenylate cyclase activity | 15385642 |
| Tgene | RAF1 | GO:0008285 | negative regulation of cell proliferation | 9765203 |
| Tgene | RAF1 | GO:0031333 | negative regulation of protein complex assembly | 19667065 |
| Tgene | RAF1 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
| Tgene | RAF1 | GO:0043066 | negative regulation of apoptotic process | 19667065 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | STAD | TCGA-HU-A4GH-01A | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000535206 | ENST00000251849 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000535206 | ENST00000442415 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000535206 | ENST00000534997 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000535206 | ENST00000542177 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000379731 | ENST00000251849 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000379731 | ENST00000442415 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000379731 | ENST00000534997 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| In-frame | ENST00000379731 | ENST00000542177 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000541851 | ENST00000251849 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000541851 | ENST00000442415 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000541851 | ENST00000534997 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
| intron-3CDS | ENST00000541851 | ENST00000542177 | B4GALT1 | chr9 | 33166756 | - | RAF1 | chr3 | 12641914 | - |
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FusionProtFeatures for B4GALT1_RAF1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| B4GALT1 | RAF1 |