|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 37333 |
FusionGeneSummary for TBC1D15_SEPHS1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TBC1D15_SEPHS1 | Fusion gene ID: 37333 | Hgene | Tgene | Gene symbol | TBC1D15 | SEPHS1 | Gene ID | 64786 | 22929 |
| Gene name | TBC1 domain family member 15 | selenophosphate synthetase 1 | |
| Synonyms | RAB7-GAP | SELD|SPS|SPS1 | |
| Cytomap | 12q21.1 | 10p13 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TBC1 domain family member 15GAP for RAB7GTPase-activating protein RAB7Tre-2-budding uninhibited by benzimidazole-cell division cycle 16 domain, domain family member 15Tre2/Bub2/Cdc16 domain family member 15 | selenide, water dikinase 1selenium donor protein 1selenophosphate synthase 1selenophosphate synthetase 1 +E9selenophosphate synthetase 1 +E9aselenophosphate synthetase 1 delta E2selenophosphate synthetase 1 delta E8selenophosphate synthetase 1 majo | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q8TC07 | P49903 | |
| Ensembl transtripts involved in fusion gene | ENST00000550746, ENST00000319106, ENST00000485960, ENST00000393309, ENST00000548679, | ENST00000327347, ENST00000378614, ENST00000545675, ENST00000537130, ENST00000494329, | |
| Fusion gene scores | * DoF score | 15 X 10 X 9=1350 | 1 X 1 X 1=1 |
| # samples | 17 | 1 | |
| ** MAII score | log2(17/1350*10)=-2.98935275580049 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: TBC1D15 [Title/Abstract] AND SEPHS1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AR-A0TW-01A | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-3UTR | ENST00000550746 | ENST00000327347 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000550746 | ENST00000378614 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000550746 | ENST00000545675 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000550746 | ENST00000537130 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-intron | ENST00000550746 | ENST00000494329 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000319106 | ENST00000327347 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000319106 | ENST00000378614 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000319106 | ENST00000545675 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000319106 | ENST00000537130 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-intron | ENST00000319106 | ENST00000494329 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000485960 | ENST00000327347 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000485960 | ENST00000378614 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000485960 | ENST00000545675 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-3UTR | ENST00000485960 | ENST00000537130 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5CDS-intron | ENST00000485960 | ENST00000494329 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5UTR-3UTR | ENST00000393309 | ENST00000327347 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5UTR-3UTR | ENST00000393309 | ENST00000378614 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5UTR-3UTR | ENST00000393309 | ENST00000545675 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5UTR-3UTR | ENST00000393309 | ENST00000537130 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| 5UTR-intron | ENST00000393309 | ENST00000494329 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| intron-3UTR | ENST00000548679 | ENST00000327347 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| intron-3UTR | ENST00000548679 | ENST00000378614 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| intron-3UTR | ENST00000548679 | ENST00000545675 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| intron-3UTR | ENST00000548679 | ENST00000537130 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
| intron-intron | ENST00000548679 | ENST00000494329 | TBC1D15 | chr12 | 72266782 | + | SEPHS1 | chr10 | 13361034 | - |
Top |
FusionProtFeatures for TBC1D15_SEPHS1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TBC1D15 | SEPHS1 |