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Fusion gene ID: 37262

FusionGeneSummary for TARDBP_XRN2

Fusion gene summary

Fusion gene information	Fusion gene name: TARDBP_XRN2
	Fusion gene ID: 37262
		Hgene	Tgene
	Gene symbol	TARDBP	XRN2
	Gene ID	23435	22803
	Gene name	TAR DNA binding protein	5'-3' exoribonuclease 2
	Synonyms	ALS10\|TDP-43	-
	Cytomap	1p36.22	20p11.22
	Type of gene	protein-coding	protein-coding
	Description	TAR DNA-binding protein 43TAR DNA-binding protein-43	5'-3' exoribonuclease 2DHP proteinDhm1-like protein
	Modification date	20180527	20180519
	UniProtAcc	Q13148	Q9H0D6
	Ensembl transtripts involved in fusion gene	ENST00000240185, ENST00000439080, ENST00000315091, ENST00000480464,	ENST00000377191, ENST00000430571, ENST00000539513,
Fusion gene scores	* DoF score	3 X 3 X 2=18	4 X 4 X 1=16
	# samples	3	4
	** MAII score	log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(4/16*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context	PubMed: TARDBP [Title/Abstract] AND XRN2 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	TARDBP	GO:0008380	RNA splicing	11285240
Hgene	TARDBP	GO:0043922	negative regulation by host of viral transcription	7745706
Hgene	TARDBP	GO:0070935	3'-UTR-mediated mRNA stabilization	17481916
Tgene	XRN2	GO:0000738	DNA catabolic process, exonucleolytic	15565158

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChiTaRS3.1			BF356570	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
In-frame	ENST00000240185	ENST00000377191	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
In-frame	ENST00000240185	ENST00000430571	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
In-frame	ENST00000240185	ENST00000539513	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
In-frame	ENST00000439080	ENST00000377191	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
In-frame	ENST00000439080	ENST00000430571	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
In-frame	ENST00000439080	ENST00000539513	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000315091	ENST00000377191	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000315091	ENST00000430571	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000315091	ENST00000539513	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000480464	ENST00000377191	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000480464	ENST00000430571	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+
intron-3CDS	ENST00000480464	ENST00000539513	TARDBP	chr1	11082553	+	XRN2	chr20	21314397	+

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FusionProtFeatures for TARDBP_XRN2

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
TARDBP Q13148	XRN2 Q9H0D6

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Fusion gene ID: 37262

FusionGeneSummary for TARDBP_XRN2

FusionProtFeatures for TARDBP_XRN2