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Fusion gene ID: 37250 |
FusionGeneSummary for TAPT1_LDB2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAPT1_LDB2 | Fusion gene ID: 37250 | Hgene | Tgene | Gene symbol | TAPT1 | LDB2 | Gene ID | 202018 | 9079 |
| Gene name | transmembrane anterior posterior transformation 1 | LIM domain binding 2 | |
| Synonyms | CMVFR|OCLSBG | CLIM1|LDB-2|LDB1 | |
| Cytomap | 4p15.32 | 4p15.32 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transmembrane anterior posterior transformation protein 1 homologcytomegalovirus partial fusion receptor | LIM domain-binding protein 2LIM binding domain 2LIM domain-binding factor CLIM1LIM domain-binding factor-2carboxyl-terminal LIM domain-binding protein 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q6NXT6 | O43679 | |
| Ensembl transtripts involved in fusion gene | ENST00000405303, ENST00000399920, ENST00000304584, ENST00000508888, | ENST00000515064, ENST00000441778, ENST00000304523, ENST00000502640, ENST00000503178, ENST00000503829, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 5 X 4=100 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/100*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAPT1 [Title/Abstract] AND LDB2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAPT1 | GO:0045724 | positive regulation of cilium assembly | 26365339 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BLCA | TCGA-DK-A3IN-01A | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000405303 | ENST00000515064 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| Frame-shift | ENST00000405303 | ENST00000441778 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| Frame-shift | ENST00000405303 | ENST00000304523 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| Frame-shift | ENST00000405303 | ENST00000502640 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| 5CDS-5UTR | ENST00000405303 | ENST00000503178 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| 5CDS-5UTR | ENST00000405303 | ENST00000503829 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| 5UTR-3CDS | ENST00000399920 | ENST00000515064 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| 5UTR-3CDS | ENST00000399920 | ENST00000441778 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| 5UTR-3CDS | ENST00000399920 | ENST00000304523 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| 5UTR-3CDS | ENST00000399920 | ENST00000502640 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| 5UTR-5UTR | ENST00000399920 | ENST00000503178 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| 5UTR-5UTR | ENST00000399920 | ENST00000503829 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-3CDS | ENST00000304584 | ENST00000515064 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-3CDS | ENST00000304584 | ENST00000441778 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-3CDS | ENST00000304584 | ENST00000304523 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-3CDS | ENST00000304584 | ENST00000502640 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-5UTR | ENST00000304584 | ENST00000503178 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-5UTR | ENST00000304584 | ENST00000503829 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-3CDS | ENST00000508888 | ENST00000515064 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-3CDS | ENST00000508888 | ENST00000441778 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-3CDS | ENST00000508888 | ENST00000304523 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-3CDS | ENST00000508888 | ENST00000502640 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-5UTR | ENST00000508888 | ENST00000503178 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
| intron-5UTR | ENST00000508888 | ENST00000503829 | TAPT1 | chr4 | 16227882 | - | LDB2 | chr4 | 16597498 | - |
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FusionProtFeatures for TAPT1_LDB2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAPT1 | LDB2 |