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Fusion gene ID: 37217 |
FusionGeneSummary for TAOK1_MAP2K4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAOK1_MAP2K4 | Fusion gene ID: 37217 | Hgene | Tgene | Gene symbol | TAOK1 | MAP2K4 | Gene ID | 57551 | 6416 |
| Gene name | TAO kinase 1 | mitogen-activated protein kinase kinase 4 | |
| Synonyms | KFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1 | JNKK|JNKK1|MAPKK4|MEK4|MKK4|PRKMK4|SAPKK-1|SAPKK1|SEK1|SERK1|SKK1 | |
| Cytomap | 17q11.2 | 17p12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kin | dual specificity mitogen-activated protein kinase kinase 4JNK-activated kinase 1JNK-activating kinase 1MAP kinase kinase 4MAPK/ERK kinase 4MAPKK 4MEK 4SAPK/ERK kinase 1c-Jun N-terminal kinase kinase 1stress-activated protein kinase kinase 1 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q7L7X3 | P45985 | |
| Ensembl transtripts involved in fusion gene | ENST00000261716, ENST00000536202, | ENST00000353533, ENST00000415385, ENST00000581941, | |
| Fusion gene scores | * DoF score | 27 X 13 X 16=5616 | 6 X 5 X 5=150 |
| # samples | 28 | 5 | |
| ** MAII score | log2(28/5616*10)=-4.32604420335959 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/150*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAOK1 [Title/Abstract] AND MAP2K4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAOK1 | GO:0006974 | cellular response to DNA damage stimulus | 17396146 |
| Hgene | TAOK1 | GO:0046330 | positive regulation of JNK cascade | 16407310 |
| Hgene | TAOK1 | GO:0097194 | execution phase of apoptosis | 16407310 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-97-A4LX-01A | TAOK1 | chr17 | 27818883 | + | MAP2K4 | chr17 | 12043156 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000261716 | ENST00000353533 | TAOK1 | chr17 | 27818883 | + | MAP2K4 | chr17 | 12043156 | + |
| Frame-shift | ENST00000261716 | ENST00000415385 | TAOK1 | chr17 | 27818883 | + | MAP2K4 | chr17 | 12043156 | + |
| 5CDS-intron | ENST00000261716 | ENST00000581941 | TAOK1 | chr17 | 27818883 | + | MAP2K4 | chr17 | 12043156 | + |
| Frame-shift | ENST00000536202 | ENST00000353533 | TAOK1 | chr17 | 27818883 | + | MAP2K4 | chr17 | 12043156 | + |
| Frame-shift | ENST00000536202 | ENST00000415385 | TAOK1 | chr17 | 27818883 | + | MAP2K4 | chr17 | 12043156 | + |
| 5CDS-intron | ENST00000536202 | ENST00000581941 | TAOK1 | chr17 | 27818883 | + | MAP2K4 | chr17 | 12043156 | + |
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FusionProtFeatures for TAOK1_MAP2K4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAOK1 | MAP2K4 |