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Fusion gene ID: 37207 |
FusionGeneSummary for TAOK1_ACER3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAOK1_ACER3 | Fusion gene ID: 37207 | Hgene | Tgene | Gene symbol | TAOK1 | ACER3 | Gene ID | 57551 | 55331 |
| Gene name | TAO kinase 1 | alkaline ceramidase 3 | |
| Synonyms | KFC-B|MAP3K16|MARKK|PSK-2|PSK2|TAO1|hKFC-B|hTAOK1 | APHC|PHCA|PLDECO | |
| Cytomap | 17q11.2 | 11q13.5 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine/threonine-protein kinase TAO1MARK KinaseSTE20-like kinase PSK2kinase from chicken homolog Bmicrotubule affinity regulating kinase kinaseprostate-derived STE20-like kinase 2prostate-derived sterile 20-like kinase 2serine/threonine protein kin | alkaline ceramidase 3alkCDase 3alkaline CDase 3alkaline dihydroceramidase SB89alkaline phytoceramidasephytoceramidase, alkaline | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q7L7X3 | Q9NUN7 | |
| Ensembl transtripts involved in fusion gene | ENST00000261716, ENST00000536202, | ENST00000532485, ENST00000530182, ENST00000526597, ENST00000533873, ENST00000538157, ENST00000544113, | |
| Fusion gene scores | * DoF score | 27 X 13 X 16=5616 | 7 X 5 X 4=140 |
| # samples | 28 | 7 | |
| ** MAII score | log2(28/5616*10)=-4.32604420335959 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/140*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAOK1 [Title/Abstract] AND ACER3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAOK1 | GO:0006974 | cellular response to DNA damage stimulus | 17396146 |
| Hgene | TAOK1 | GO:0046330 | positive regulation of JNK cascade | 16407310 |
| Hgene | TAOK1 | GO:0097194 | execution phase of apoptosis | 16407310 |
| Tgene | ACER3 | GO:0046512 | sphingosine biosynthetic process | 20068046 |
| Tgene | ACER3 | GO:0071602 | phytosphingosine biosynthetic process | 11356846|20068046 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-A1-A0SM-01A | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000261716 | ENST00000532485 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-3UTR | ENST00000261716 | ENST00000530182 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000261716 | ENST00000526597 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000261716 | ENST00000533873 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000261716 | ENST00000538157 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-intron | ENST00000261716 | ENST00000544113 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| In-frame | ENST00000536202 | ENST00000532485 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-3UTR | ENST00000536202 | ENST00000530182 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000536202 | ENST00000526597 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000536202 | ENST00000533873 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-5UTR | ENST00000536202 | ENST00000538157 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
| 5CDS-intron | ENST00000536202 | ENST00000544113 | TAOK1 | chr17 | 27825539 | + | ACER3 | chr11 | 76687333 | + |
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FusionProtFeatures for TAOK1_ACER3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAOK1 | ACER3 |