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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 37179

FusionGeneSummary for TANC2_PRKCA

check button Fusion gene summary
Fusion gene informationFusion gene name: TANC2_PRKCA
Fusion gene ID: 37179
HgeneTgene
Gene symbol

TANC2

PRKCA

Gene ID

26115

5578

Gene nametetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2protein kinase C alpha
SynonymsROLSA|rolsAAG6|PKC-alpha|PKCA|PRKACA
Cytomap

17q23.2-q23.3

17q24.2

Type of geneprotein-codingprotein-coding
Descriptionprotein TANC2putative ankyrin-repeat containing proteinrolling pebbles homolog Btetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2protein kinase C alpha typePKC-Aaging-associated gene 6
Modification date2018051920180523
UniProtAcc

Q9HCD6

P17252

Ensembl transtripts involved in fusion geneENST00000424789, ENST00000389520, 
ENST00000413366, ENST00000583361, 
Fusion gene scores* DoF score26 X 12 X 11=343216 X 8 X 6=768
# samples 2715
** MAII scorelog2(27/3432*10)=-3.66801824044871
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(15/768*10)=-2.35614381022528
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TANC2 [Title/Abstract] AND PRKCA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationOncogene involved fusion gene, in-frame and retained their domain.
Kinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgenePRKCA

GO:0006468

protein phosphorylation

10770950

TgenePRKCA

GO:0035408

histone H3-T6 phosphorylation

20228790

TgenePRKCA

GO:0043536

positive regulation of blood vessel endothelial cell migration

20011604

TgenePRKCA

GO:0090330

regulation of platelet aggregation

12724315


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-43-2581-01ATANC2chr17

61151375

+PRKCAchr17

64683229

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000424789ENST00000413366TANC2chr17

61151375

+PRKCAchr17

64683229

+
5CDS-intronENST00000424789ENST00000583361TANC2chr17

61151375

+PRKCAchr17

64683229

+
In-frameENST00000389520ENST00000413366TANC2chr17

61151375

+PRKCAchr17

64683229

+
5CDS-intronENST00000389520ENST00000583361TANC2chr17

61151375

+PRKCAchr17

64683229

+

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FusionProtFeatures for TANC2_PRKCA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
TANC2

Q9HCD6

PRKCA

P17252

Calcium-activated, phospholipid- and diacylglycerol(DAG)-dependent serine/threonine-protein kinase that is involvedin positive and negative regulation of cell proliferation,apoptosis, differentiation, migration and adhesion, tumorigenesis,cardiac hypertrophy, angiogenesis, platelet function andinflammation, by directly phosphorylating targets such as RAF1,BCL2, CSPG4, TNNT2/CTNT, or activating signaling cascade involvingMAPK1/3 (ERK1/2) and RAP1GAP. Involved in cell proliferation andcell growth arrest by positive and negative regulation of the cellcycle. Can promote cell growth by phosphorylating and activatingRAF1, which mediates the activation of the MAPK/ERK signalingcascade, and/or by up-regulating CDKN1A, which facilitates activecyclin-dependent kinase (CDK) complex formation in glioma cells.In intestinal cells stimulated by the phorbol ester PMA, cantrigger a cell cycle arrest program which is associated with theaccumulation of the hyper-phosphorylated growth-suppressive formof RB1 and induction of the CDK inhibitors CDKN1A and CDKN1B.Exhibits anti-apoptotic function in glioma cells and protects themfrom apoptosis by suppressing the p53/TP53-mediated activation ofIGFBP3, and in leukemia cells mediates anti-apoptotic action byphosphorylating BCL2. During macrophage differentiation induced bymacrophage colony-stimulating factor (CSF1), is translocated tothe nucleus and is associated with macrophage development. Afterwounding, translocates from focal contacts to lamellipodia andparticipates in the modulation of desmosomal adhesion. Plays arole in cell motility by phosphorylating CSPG4, which inducesassociation of CSPG4 with extensive lamellipodia at the cellperiphery and polarization of the cell accompanied by increases incell motility. During chemokine-induced CD4(+) T cell migration,phosphorylates CDC42-guanine exchange factor DOCK8 resulting inits dissociation from LRCH1 and the activation of GTPase CDC42(PubMed:28028151). Is highly expressed in a number of cancer cellswhere it can act as a tumor promoter and is implicated inmalignant phenotypes of several tumors such as gliomas and breastcancers. Negatively regulates myocardial contractility andpositively regulates angiogenesis, platelet aggregation andthrombus formation in arteries. Mediates hypertrophic growth ofneonatal cardiomyocytes, in part through a MAPK1/3 (ERK1/2)-dependent signaling pathway, and upon PMA treatment, is requiredto induce cardiomyocyte hypertrophy up to heart failure and death,by increasing protein synthesis, protein-DNA ratio and cellsurface area. Regulates cardiomyocyte function by phosphorylatingcardiac troponin T (TNNT2/CTNT), which induces significantreduction in actomyosin ATPase activity, myofilament calciumsensitivity and myocardial contractility. In angiogenesis, isrequired for full endothelial cell migration, adhesion tovitronectin (VTN), and vascular endothelial growth factor A(VEGFA)-dependent regulation of kinase activation and vasculartube formation. Involved in the stabilization of VEGFA mRNA atpost-transcriptional level and mediates VEGFA-induced cellproliferation. In the regulation of calcium-induced plateletaggregation, mediates signals from the CD36/GP4 receptor forgranule release, and activates the integrin heterodimer ITGA2B-ITGB3 through the RAP1GAP pathway for adhesion. During response tolipopolysaccharides (LPS), may regulate selective LPS-inducedmacrophage functions involved in host defense and inflammation.But in some inflammatory responses, may negatively regulate NF-kappa-B-induced genes, through IL1A-dependent induction of NF-kappa-B inhibitor alpha (NFKBIA/IKBA). Upon stimulation with 12-O-tetradecanoylphorbol-13-acetate (TPA), phosphorylates EIF4G1,which modulates EIF4G1 binding to MKNK1 and may be involved in theregulation of EIF4E phosphorylation. Phosphorylates KIT, leadingto inhibition of KIT activity. Phosphorylates ATF2 which promotescooperation between ATF2 and JUN, activating transcription.{ECO:0000269|PubMed:10848585, ECO:0000269|PubMed:11909826,ECO:0000269|PubMed:12724315, ECO:0000269|PubMed:12832403,ECO:0000269|PubMed:15016832, ECO:0000269|PubMed:15504744,ECO:0000269|PubMed:15526160, ECO:0000269|PubMed:18056764,ECO:0000269|PubMed:19176525, ECO:0000269|PubMed:21576361,ECO:0000269|PubMed:23990668, ECO:0000269|PubMed:28028151,ECO:0000269|PubMed:9738012, ECO:0000269|PubMed:9830023,ECO:0000269|PubMed:9873035, ECO:0000269|PubMed:9927633}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRKCAchr17:61151375chr17:64683229ENST00000413366+417339_597176673DomainProtein kinase
TgenePRKCAchr17:61151375chr17:64683229ENST00000413366+417598_668176673DomainNote=AGC-kinase C-terminal
TgenePRKCAchr17:61151375chr17:64683229ENST00000413366+417345_353176673Nucleotide bindingATP

- In-frame and not-retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+2261033_1062462001RepeatNote=ANK 6
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+2261066_1095462001RepeatNote=ANK 7
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+2261099_1128462001RepeatNote=ANK 8
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+2261132_1161462001RepeatNote=ANK 9
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+2261165_1194462001RepeatNote=ANK 10
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+2261198_1227462001RepeatNote=ANK 11
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+2261244_1277462001RepeatNote=TPR 1
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+2261291_1324462001RepeatNote=TPR 2
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+2261325_1358462001RepeatNote=TPR 3
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+226846_878462001RepeatNote=ANK 1
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+226884_913462001RepeatNote=ANK 2
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+226917_946462001RepeatNote=ANK 3
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+226950_979462001RepeatNote=ANK 4
HgeneTANC2chr17:61151375chr17:64683229ENST00000389520+226990_1019462001RepeatNote=ANK 5
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+2251033_1062461991RepeatNote=ANK 6
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+2251066_1095461991RepeatNote=ANK 7
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+2251099_1128461991RepeatNote=ANK 8
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+2251132_1161461991RepeatNote=ANK 9
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+2251165_1194461991RepeatNote=ANK 10
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+2251198_1227461991RepeatNote=ANK 11
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+2251244_1277461991RepeatNote=TPR 1
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+2251291_1324461991RepeatNote=TPR 2
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+2251325_1358461991RepeatNote=TPR 3
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+225846_878461991RepeatNote=ANK 1
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+225884_913461991RepeatNote=ANK 2
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+225917_946461991RepeatNote=ANK 3
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+225950_979461991RepeatNote=ANK 4
HgeneTANC2chr17:61151375chr17:64683229ENST00000424789+225990_1019461991RepeatNote=ANK 5
TgenePRKCAchr17:61151375chr17:64683229ENST00000413366+417172_260176673DomainC2
TgenePRKCAchr17:61151375chr17:64683229ENST00000413366+417101_151176673Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCAchr17:61151375chr17:64683229ENST00000413366+41736_86176673Zinc fingerPhorbol-ester/DAG-type 1


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FusionGeneSequence for TANC2_PRKCA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_TANC2_ENST00000424789_chr17_61151375_+_PRKCA_ENST00000413366_chr17_64683229_+_543aa
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLN
PQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKL
GPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFL
TQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMM
DGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKR
LGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQS

>In-frame_TANC2_ENST00000389520_chr17_61151375_+_PRKCA_ENST00000413366_chr17_64683229_+_543aa
MFRNSLKMLLTGGKSSRKNRSSDGGSEEPPDRRQSSVDSRQSRSGQVRDAKNLIPMDPNGLSDPYVKLKLIPDPKNESKQKTKTIRSTLN
PQWNESFTFKLKPSDKDRRLSVEIWDWDRTTRNDFMGSLSFGVSELMKMPASGWYKLLNQEEGEYYNVPIPEGDEEGNMELRQKFEKAKL
GPAGNKVISPSEDRKQPSNNLDRVKLTDFNFLMVLGKGSFGKVMLADRKGTEELYAIKILKKDVVIQDDDVECTMVEKRVLALLDKPPFL
TQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISIGLFFLHKRGIIYRDLKLDNVMLDSEGHIKIADFGMCKEHMM
DGVTTRTFCGTPDYIAPEIIAYQPYGKSVDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSVCKGLMTKHPAKR
LGCGPEGERDVREHAFFRRIDWEKLENREIQPPFKPKVCGKGAENFDKFFTRGQPVLTPPDQLVIANIDQSDFEGFSYVNPQFVHPILQS


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_TANC2_ENST00000424789_chr17_61151375_+_PRKCA_ENST00000413366_chr17_64683229_+_1629nt
ATGTTTCGGAATAGTCTCAAGATGCTGCTTACTGGTGGGAAATCAAGTCGTAAAAACAGGTCAAGTGATGGAGGGAGCGAGGAACCACCG
GATCGAAGACAGTCAAGTGTAGACTCTCGCCAAAGCCGCTCTGGGCAAGTACGAGATGCAAAAAATCTAATCCCTATGGATCCAAACGGG
CTTTCAGATCCTTATGTGAAGCTGAAACTTATTCCTGATCCCAAGAATGAAAGCAAGCAAAAAACCAAAACCATCCGCTCCACACTAAAT
CCGCAGTGGAATGAGTCCTTTACATTCAAATTGAAACCTTCAGACAAAGACCGACGACTGTCTGTAGAAATCTGGGACTGGGATCGAACA
ACAAGGAATGACTTCATGGGATCCCTTTCCTTTGGAGTTTCGGAGCTGATGAAGATGCCGGCCAGTGGATGGTACAAGTTGCTTAACCAA
GAAGAAGGTGAGTACTACAACGTACCCATTCCGGAAGGGGACGAGGAAGGAAACATGGAACTCAGGCAGAAATTCGAGAAAGCCAAACTT
GGCCCTGCTGGCAACAAAGTCATCAGTCCCTCTGAAGACAGGAAACAACCTTCCAACAACCTTGACCGAGTGAAACTCACGGACTTCAAT
TTCCTCATGGTGTTGGGAAAGGGGAGTTTTGGAAAGGTGATGCTTGCCGACAGGAAGGGCACAGAAGAACTGTATGCAATCAAAATCCTG
AAGAAGGATGTGGTGATTCAGGATGATGACGTGGAGTGCACCATGGTAGAAAAGCGAGTCTTGGCCCTGCTTGACAAACCCCCGTTCTTG
ACGCAGCTGCACTCCTGCTTCCAGACAGTGGATCGGCTGTACTTCGTCATGGAATATGTCAACGGTGGGGACCTCATGTACCACATTCAG
CAAGTAGGAAAATTTAAGGAACCACAAGCAGTATTCTATGCGGCAGAGATTTCCATCGGATTGTTCTTTCTTCATAAAAGAGGAATCATT
TATAGGGATCTGAAGTTAGATAACGTCATGTTGGATTCAGAAGGACATATCAAAATTGCTGACTTTGGGATGTGCAAGGAACACATGATG
GATGGAGTCACGACCAGGACCTTCTGTGGGACTCCAGATTATATCGCCCCAGAGATAATCGCTTATCAGCCGTATGGAAAATCTGTGGAC
TGGTGGGCCTATGGCGTCCTGTTGTATGAAATGCTTGCCGGGCAGCCTCCATTTGATGGTGAAGATGAAGACGAGCTATTTCAGTCTATC
ATGGAGCACAACGTTTCCTATCCAAAATCCTTGTCCAAGGAGGCTGTTTCTGTCTGCAAAGGACTGATGACCAAACACCCAGCCAAGCGG
CTGGGCTGTGGGCCTGAGGGGGAGAGGGACGTGAGAGAGCATGCCTTCTTCCGGAGGATCGACTGGGAAAAACTGGAGAACAGGGAGATC
CAGCCACCATTCAAGCCCAAAGTGTGTGGCAAAGGAGCAGAGAACTTTGACAAGTTCTTCACACGAGGACAGCCCGTCTTAACACCACCT
GATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTATGTCAACCCCCAGTTTGTGCACCCCATCTTACAGAGT

>In-frame_TANC2_ENST00000389520_chr17_61151375_+_PRKCA_ENST00000413366_chr17_64683229_+_1629nt
ATGTTTCGGAATAGTCTCAAGATGCTGCTTACTGGTGGGAAATCAAGTCGTAAAAACAGGTCAAGTGATGGAGGGAGCGAGGAACCACCG
GATCGAAGACAGTCAAGTGTAGACTCTCGCCAAAGCCGCTCTGGGCAAGTACGAGATGCAAAAAATCTAATCCCTATGGATCCAAACGGG
CTTTCAGATCCTTATGTGAAGCTGAAACTTATTCCTGATCCCAAGAATGAAAGCAAGCAAAAAACCAAAACCATCCGCTCCACACTAAAT
CCGCAGTGGAATGAGTCCTTTACATTCAAATTGAAACCTTCAGACAAAGACCGACGACTGTCTGTAGAAATCTGGGACTGGGATCGAACA
ACAAGGAATGACTTCATGGGATCCCTTTCCTTTGGAGTTTCGGAGCTGATGAAGATGCCGGCCAGTGGATGGTACAAGTTGCTTAACCAA
GAAGAAGGTGAGTACTACAACGTACCCATTCCGGAAGGGGACGAGGAAGGAAACATGGAACTCAGGCAGAAATTCGAGAAAGCCAAACTT
GGCCCTGCTGGCAACAAAGTCATCAGTCCCTCTGAAGACAGGAAACAACCTTCCAACAACCTTGACCGAGTGAAACTCACGGACTTCAAT
TTCCTCATGGTGTTGGGAAAGGGGAGTTTTGGAAAGGTGATGCTTGCCGACAGGAAGGGCACAGAAGAACTGTATGCAATCAAAATCCTG
AAGAAGGATGTGGTGATTCAGGATGATGACGTGGAGTGCACCATGGTAGAAAAGCGAGTCTTGGCCCTGCTTGACAAACCCCCGTTCTTG
ACGCAGCTGCACTCCTGCTTCCAGACAGTGGATCGGCTGTACTTCGTCATGGAATATGTCAACGGTGGGGACCTCATGTACCACATTCAG
CAAGTAGGAAAATTTAAGGAACCACAAGCAGTATTCTATGCGGCAGAGATTTCCATCGGATTGTTCTTTCTTCATAAAAGAGGAATCATT
TATAGGGATCTGAAGTTAGATAACGTCATGTTGGATTCAGAAGGACATATCAAAATTGCTGACTTTGGGATGTGCAAGGAACACATGATG
GATGGAGTCACGACCAGGACCTTCTGTGGGACTCCAGATTATATCGCCCCAGAGATAATCGCTTATCAGCCGTATGGAAAATCTGTGGAC
TGGTGGGCCTATGGCGTCCTGTTGTATGAAATGCTTGCCGGGCAGCCTCCATTTGATGGTGAAGATGAAGACGAGCTATTTCAGTCTATC
ATGGAGCACAACGTTTCCTATCCAAAATCCTTGTCCAAGGAGGCTGTTTCTGTCTGCAAAGGACTGATGACCAAACACCCAGCCAAGCGG
CTGGGCTGTGGGCCTGAGGGGGAGAGGGACGTGAGAGAGCATGCCTTCTTCCGGAGGATCGACTGGGAAAAACTGGAGAACAGGGAGATC
CAGCCACCATTCAAGCCCAAAGTGTGTGGCAAAGGAGCAGAGAACTTTGACAAGTTCTTCACACGAGGACAGCCCGTCTTAACACCACCT
GATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTATGTCAACCCCCAGTTTGTGCACCCCATCTTACAGAGT


* Fusion transcript sequences (Full-length transcript).
>In-frame_TANC2_ENST00000424789_chr17_61151375_+_PRKCA_ENST00000413366_chr17_64683229_+_8339nt
AACCATGTTTCGGAATAGTCTCAAGATGCTGCTTACTGGTGGGAAATCAAGTCGTAAAAACAGGTCAAGTGATGGAGGGAGCGAGGAACC
ACCGGATCGAAGACAGTCAAGTGTAGACTCTCGCCAAAGCCGCTCTGGGCAAGTACGAGATGCAAAAAATCTAATCCCTATGGATCCAAA
CGGGCTTTCAGATCCTTATGTGAAGCTGAAACTTATTCCTGATCCCAAGAATGAAAGCAAGCAAAAAACCAAAACCATCCGCTCCACACT
AAATCCGCAGTGGAATGAGTCCTTTACATTCAAATTGAAACCTTCAGACAAAGACCGACGACTGTCTGTAGAAATCTGGGACTGGGATCG
AACAACAAGGAATGACTTCATGGGATCCCTTTCCTTTGGAGTTTCGGAGCTGATGAAGATGCCGGCCAGTGGATGGTACAAGTTGCTTAA
CCAAGAAGAAGGTGAGTACTACAACGTACCCATTCCGGAAGGGGACGAGGAAGGAAACATGGAACTCAGGCAGAAATTCGAGAAAGCCAA
ACTTGGCCCTGCTGGCAACAAAGTCATCAGTCCCTCTGAAGACAGGAAACAACCTTCCAACAACCTTGACCGAGTGAAACTCACGGACTT
CAATTTCCTCATGGTGTTGGGAAAGGGGAGTTTTGGAAAGGTGATGCTTGCCGACAGGAAGGGCACAGAAGAACTGTATGCAATCAAAAT
CCTGAAGAAGGATGTGGTGATTCAGGATGATGACGTGGAGTGCACCATGGTAGAAAAGCGAGTCTTGGCCCTGCTTGACAAACCCCCGTT
CTTGACGCAGCTGCACTCCTGCTTCCAGACAGTGGATCGGCTGTACTTCGTCATGGAATATGTCAACGGTGGGGACCTCATGTACCACAT
TCAGCAAGTAGGAAAATTTAAGGAACCACAAGCAGTATTCTATGCGGCAGAGATTTCCATCGGATTGTTCTTTCTTCATAAAAGAGGAAT
CATTTATAGGGATCTGAAGTTAGATAACGTCATGTTGGATTCAGAAGGACATATCAAAATTGCTGACTTTGGGATGTGCAAGGAACACAT
GATGGATGGAGTCACGACCAGGACCTTCTGTGGGACTCCAGATTATATCGCCCCAGAGATAATCGCTTATCAGCCGTATGGAAAATCTGT
GGACTGGTGGGCCTATGGCGTCCTGTTGTATGAAATGCTTGCCGGGCAGCCTCCATTTGATGGTGAAGATGAAGACGAGCTATTTCAGTC
TATCATGGAGCACAACGTTTCCTATCCAAAATCCTTGTCCAAGGAGGCTGTTTCTGTCTGCAAAGGACTGATGACCAAACACCCAGCCAA
GCGGCTGGGCTGTGGGCCTGAGGGGGAGAGGGACGTGAGAGAGCATGCCTTCTTCCGGAGGATCGACTGGGAAAAACTGGAGAACAGGGA
GATCCAGCCACCATTCAAGCCCAAAGTGTGTGGCAAAGGAGCAGAGAACTTTGACAAGTTCTTCACACGAGGACAGCCCGTCTTAACACC
ACCTGATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTATGTCAACCCCCAGTTTGTGCACCCCATCTTACA
GAGTGCAGTATGAAACTCACCAGCGAGAACAAACACCTCCCCAGCCCCCAGCCCTCCCCGCAGTGGGAAGTGAATCCTTAACCCTAAAAT
TTTAAGGCCACGGCCTTGTGTCTGATTCCATATGGAGGCCTGAAAATTGTAGGGTTATTAGTCCAAATGTGATCAACTGTTCAGGGTCTC
TCTCTTACAACCAAGAACATTATCTTAGTGGAAGATGGTACGTCATGCTCAGTGTCCAGTTTAATTCTGTAGAAGTTACGTCTGGCTCTA
GGTTAACCCTTCCTAGAAAGCAAGCAGACTGTTGCCCCATTTTGGGTACAATTTGATATACTTTCCATACCCTCCATCTGTGGATTTTTC
AGCATTGGAATCCCCCAACCAGAGATGTTAAAGTGAGCCTGTCCCAGGAAACATCTCCACCCAAGACGTCTTTGGAATCCAAGAACAGGA
AGCCAAGAGAGTGAGCAGGGAGGGATTGGGGGTGGGGGAGGCCTCAAAATACCGACTGCGTCCATTCTCTGCCTCCATGGAAACAGCCCC
TAGAATCTGAAAGGCCGGGATAAACCTAATCACTGTTCCCAAACATTGACAAATCCTAACCCAACCATGGTCCAGCAGTTACCAGTTTAA
ACAAAAAAACCTCAGATGAGTGTTGGGTGAATCTGTCATCTGGTACCCTCCTTGGTTGATAACTGTCTTGATACTTTTCATTCTTTGTAA
GAGGCCAAATCGTCTAAGGACGTTGCTGAACAAGCGTGTGAAATCATTTCAGATCAAGGATAAGCCAGTGTGTACATATGTTCATTTTAA
TCTCTGGGAGATTATTTTTCCATCCAGGGTGCCATCAGTAATCATGCCACTACTCACCAGTGTTGTTCACCAACACCCACCCCCACACAC
ACCAACATTTTGCTGCCTACCTTGTTATCCTTCTCAAGAAGCTGAAGTGTACGCCCTCTCCCCTTTTGTGCTTATTTATTTAATAGGCTG
CAGTGTCGCTTATGAAAGTACGATGTACAGTAACTTAATGGAAGTGCTGACTCTAGCATCAGCCTCTACCGATTGATTTTCCTCCCTTCT
CTAGCCCTGGATGTCCACTTAGGGATAAAAAGAATATGGTTTTGGTTCCCATTTCTAGTTCACGTTGAATGACAGGCCTGGAGCTGTAGA
ATCAGGAAACCCGGATGCCTAACAGCTCAAAGATGTTTTGTTAATAGAAGGATTTTAATACGTTTTGCAAATGCATCATGCAATGAATTT
TGCATGTTTATAATAAACCTTAATAACAAGTGAATCTATATTATTGATATAATCGTATCAAGTATAAAGAGAGTATTATAATAATTTTAT
AAGACACAATTGTGCTCTATTTGTGCAGGTTCTTGTTTCTAATCCTCTTTTCTAATTAAGTTTTAGCTGAATCCCTTGCTTCTGTGCTTT
CCCTCCCTGCACATGGGCACTGTATCAGATAGATTACTTTTTAAATGTAGATAAAATTTCAAAAATGAATGGCTAGTTTACGTGATAGAT
TAGGCTCTTACTACATATGTGTGTGTATATATATGTATTTGATTCTACCTGCAAACAAATTTTTATTGGTGAGGACTATTTTTGAGCTGA
CACTCCCTCTTAGTTTCTTCATGTCACCTTTCGTCCTGGTTCCTCCGCCACTCTTCCTCTTGGGGACAACAGGAAGTGTCTGATTCCAGT
CTGCCTAGTACGTTGGTACACACGTGGCATTGCCGCAGCACCTGGGCTGACCTTTGTGTGTGCGTGTGTGTGTGTTTCCTTCTTCCCTTC
AGCCTGTGACTGTTGCTGACTCCAGGGGTGGGAGGGATGGGGAGACTCCCCTCTTGCTGTGTGTACTGGACACGCAGGAAGCATGCTGTC
TTGCTGCCTCTGCAACGACCTGTCGTTTGCTCCAGCATGCACAAACTTCGTGAGACCAACACAGCCGTGCCCTGCAGGCACCAGCACGTG
CTTTTCAGAGGCTGCGGACTTTCTTCCAGCCATTGTGGCATTGGCCTTTCCAGTCTTGGGAGGAGCGCGCTGCTTTGGTGAGACACCCCC
ATGCAAGGTCCTCAGAGTAGCCGGGTTCTACCACAAACAGAAACAGAATGAAAGTAGCTGTCAGTCCTTGTAGAGAGCCGCTCTGTTTCC
TCCCAGAAGCATCTCCCAGCTAAGCTCGCATTATTTTTCTCCTCTGGCTGTTTGCCTGAAGTTCACAGAACACACAACCATGAAAGGCTT
TTTGAGGTGAGAGGCCCAGGTGGTCCTGGCAACCCTGAGTAGAAGGAGAGACGGGGTAGGGAACGGGCCCGGCCAGAAAAGAACCATTTC
TTCTGCCATCTTTTATGCACCATAGACATCGAGACTCCAGGGGGTCCTGGCTCCCCTGTCCCTGCAGCCCTGCAGGTCAGTGCATGATCT
GGGTTCGTGTCCTGACCAGGTGCTCCTCCTTTGATCCGAGGGGAAAGGGACTGGTTTATAGAAAGAGCCTAGGAGACAAAAGGGCCAGTC
CCCCTGCCCAGAATGGAGCAGCAGCAGGACAGACCCCCACGAGGCCCCCCAGAGAGGAGGAAGATCCCACGGAGGAACACATGAGGTTAG
GGACCCTTGTTCAGCACCCCAAACAGCCTGCCTGTTTAAAGCAGGCAGCAGGCTTAGGCCTTCCCTGCAACCCCAACACCCACAAGTTTG
TTTCTCTAGGAAACACATTCACTGTCTCAGCTGGCTGTTACTCTCTCAGACCATATGGCAAAGTTTTCCAAGAAAATGCCCCGACAGGGG
TGCCCAGCACACTGCCTGAGGGACAACAGACATCAGAACAAACCCCCAGAGAGAAACAGTCAAAATCAGGGCCCGGTGCAGTGTTGTCAT
GTGGAACCTGCTTTATCCATTGCTGAGTGTTGAATGTGGGTAATGGTTAGGGCTTTCCAGATCTCAGCAGCCAAAGACAGTTATTGTTGG
AAGACTGTCATGTAGATAACCATGAGCAATGGCTCGCCTCAGAATCAGTTCATAAAATTCTATGGTACTGGCCCCTTCGTGGGTATTGTG
TGAAATGAGATGGTGGCGAGGGGTGCGCTGTGGAACTGCCGCAGCCACGCAGGAGGTCCCTGGGGGATGCTTTGGGAAGTCCTTGCCCCT
GAGCACTGCCTGATTGCCAGGGCCTGTGGAGGTCTAGGCCGCCTGGCAGAATCTAGCACCGTCCGAATCCCCGCAGGACCCATGGAGCTA
TGACCACACCAGGCCATTCAAATGGCTCTGCATTATCTTCCCTTGGAAGGTGGCCACTCCTCGGTGGCAGGGCCTTTCCCTGAGGCTGCA
GGCCGTGGGCTGGCAGCCCGTCTCTTGGCATTTCAATTGAAGGTCACCAGGTGCTGGGTTTGAAAGGAAGTCACTGGAGTGCTGCCAGGG
GCCGCCCTCCAAGGTTAATGAGAGGCCCACATCCAGGCAAGAACTAATTCAAAAGGCAGATCAGAAACCACAGGAGTCAAAATTATTGCT
CCGGCAGTGCTTCCCTTCCTTTCATCCACTGGCCTCGTGTGGTCCATGCAGGGCCACTGTCTGCCCTTTCTGATGCCACGTATTAGGCTT
TCTTACTCAGAATTTTGATAGAAAACCATGGGGCCAAGAGCTCTGGAAGCCTGGCCGGAAAGACCAAGGTTCATGCAGCCCAACAAATGA
TTGTTGAGCACCTCTCGGAGCCAAAGTCCTTAGGCGAGTGTGGTGACTTCCTGGAAGGAGGATGCAGACTTCCAGAGAGCCCCCCCAACG
GACGTGCTGAGAAGGGAGAGGGAGGCGGGGGCTGTAGTCAGGAAGGAGCCAGAGAAGAACAGGGTTTGGGTGCATCCAGAAATATGCCTG
CAGTAGGAGGGAGAGGAAGGGGTGCCACCGTCAACGGCTTCCCATCGGAGGTGGTTGGTGCAGATGGAAGTTTCTGTCTGCTGGCCCTCA
AGAGAGTGTTTTGCCAGGGACACAGTCTGTTCCTCCTCAGAAAACACCCCCCAAATGCTAACAACATCCCCACCAGCTGCTAGAAGCCCC
TTTCCCCTCCCCACCTTGAAGTAGCTCATAGTTCTCTGGGCAGAGCCAGACCATCCAGTGTACCCCAGAGGCCAGTAGGTTCCTGCCCAT
TTTCCTCTCTGGCTTCCTGCCAAGAATTATGGCAGCTGAGGATGAATGGAGAAGTAAAAACAACTAACACCGCACAACTAACAACTAACA
CCGCAGTTCCCACCTGGGTTCCACTTAGCAGGAGACATTTCGGAGGGTTTTTTTTGTTTTTGTTCCTGTTTTTTTTTTTTTTGCTGGAAT
TTGTTTTCTCAGTACTGAAAAGAGAAAAAGTGACAATCTTGTATTTTTAAAAGCCTCGGAAAGGTGATACCATCTGACAGTCATTTTCTC
ACGTTGGTCTTCTAAAGTCACCTATTTCTTGTGTGTGCACATCACACCATTTCCTGTTTCTTTATAACCCGACAAGGGTAGGAGTGCCTG
TTTCCCCTGCTGGGCACACCAGACAATCGTAATCACAAAACAGACACTGAGCCAGGGGCCCAAAGGGTGTGATCATGAGAGTTACCGGGA
CAGCAGTAGGCATGACAGTCACCAGGAAGGACAAGGGTGCTCTGTTGTTAGTGGCCACACACCAATTTGACAAGGAGTGTTGCGAAATTT
TTATTTATTTATTTATTTATTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCGGTGGTACAATCTCGGCTCACTGCAACCT
CCACCTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGACTACAGGTGCGTGCCACCACACCCAGCTAAATTTTGT
GTTTTTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTTGAACCCCTGACCTCATGATCTGCCTGCCTCGGCCTCCCAAAGTG
CTGGGATTACAGGCATGAGCCACCACGCCCAGCCAAAATATTTTTTTAAAGTCATTTTCCTTAAGCTGCTTGGGCTACATGTGAAATACA
CTGGACGGTCAACATTCCTGTCTCCTCCCATTTGGGCTGATGCAGCAGATCCAGGGAATGTTACCTGTTTCTGCTGCTAGAAGATCCAGG
AAATTGGGAAGGTTACCTGACGCACACATGGATGAAGGCCATCATCTAGAAATGGGGTCAACCACAATTGTGTTAATTCCGTAGTGTCAG
GGATTCTTCGGGAAGGTCAACAGTATGAAGGATTCTGACCCCTGTGCCTCCCATTTATGTGATCAGGTGACAGTTAATAACCGTGGAGGT
CACACTCAGCCATCCAACAGCCTTACAGTGACCCTACACAAAAGCCCCCAAATTCCAAAGACTTTTTCTTAACCTAAAGGAAGAAATTAT
TTGTTAATTCCAGTAGAGCAACTGAATATACTGGGCTATTTGTACTTTTTTATAGAGAACTTTAATAATAATTCTTTAAAAATGAGTTTT
TAGAACAAAGCAACTGACGATTTCCTAAGATTCCAATGCCCTGGAGCTTGTAGGAGGACTTAGCCTGGGTCAGCTGGAGCACCCCCGACC
TGATCTCCCACTGCCAGATTTTCCCATGCTCCTAGGGTATGGAGTCCACGTGGGAATGACTGCAAGTTCAGGTGGAACTTGGCCGACTGA
TGCTCTGCGAGTTTTTAATAGACACTGGGGACAACTGCTTAAGGTTTAGAAACTTCCAAACCACAGGAAAGACATTTTTAGTGTCCCCCA
TCCAGAGGCAGCCCTGGAATAGGATTCCCAGGGGTTTCTGGGACCCCTTTCCTTGCTCCGTGAGGCTCTGTGGCCATCTTTTGGCAGGAG
GAGGATGCTTCCTTGGCTCTGTGCCCAGACCCGCCTGGTCCCCAGGTCTCTCACCTTGGGTGAAGATTCAGAGATGCCCTGTAAGGATTT
TGCCCACTGGGCAACTCAGAAATACTTCGATCTCCCAAGATATAAGAGGCAGCAGCAAACGTGCCTATTGACGTCTGTTTCATAGTTACC
ACTTACGCGAGTAGACAGAACTCGGCTTTTCAGAAAATAGGTGTCAAGTCCACTTTATAAGAACCTTTTTTTCTAAAATAAGATAAAAGG
TGGCTTTGCATTTTCTGATTAAACGACTGTGTCTTTGTCACCTCTGCTTAACTTTAGGAGTATCCATTCCTGTGATTGTAGACTTTTGTT
GATATTCTTCCTGGAAGAATATCATTCTTTTCTTGAAGGGTTGGTTTACTAGAATATTCAAAATCAATCATGAAGGCAGTTACTATTTTG
AGTCTAAAGGTTTTCTAAAAATTAACCTCACATCCCTTCTGTTAGGGTCTTTCAGAATATCTTTTATAAACAGAAGCATTTGAAGTCATT
GCTTTTGCTACATGATTTGTGTGTGTGAAGGACATACCACGTTTAAATCATTAATTGAAAAACATCATATAAGCCCCAACTTTGTTTGGA
GGAAGAGACGGAGGTTGAGGTTTTTCCTTCTGTATAAGCACCTACTGACAAAATGTAGAGGCCATTCAACCGTCAAACACCATTTGGTTA
TATCGCAGAGGAGACGGATGTGTAAATTACTGCATTGCTTTTTTTTTCAGTTTGTATAACCTCTAATCTCCGTTTGCATGATACGCTTTG

>In-frame_TANC2_ENST00000389520_chr17_61151375_+_PRKCA_ENST00000413366_chr17_64683229_+_8335nt
ATGTTTCGGAATAGTCTCAAGATGCTGCTTACTGGTGGGAAATCAAGTCGTAAAAACAGGTCAAGTGATGGAGGGAGCGAGGAACCACCG
GATCGAAGACAGTCAAGTGTAGACTCTCGCCAAAGCCGCTCTGGGCAAGTACGAGATGCAAAAAATCTAATCCCTATGGATCCAAACGGG
CTTTCAGATCCTTATGTGAAGCTGAAACTTATTCCTGATCCCAAGAATGAAAGCAAGCAAAAAACCAAAACCATCCGCTCCACACTAAAT
CCGCAGTGGAATGAGTCCTTTACATTCAAATTGAAACCTTCAGACAAAGACCGACGACTGTCTGTAGAAATCTGGGACTGGGATCGAACA
ACAAGGAATGACTTCATGGGATCCCTTTCCTTTGGAGTTTCGGAGCTGATGAAGATGCCGGCCAGTGGATGGTACAAGTTGCTTAACCAA
GAAGAAGGTGAGTACTACAACGTACCCATTCCGGAAGGGGACGAGGAAGGAAACATGGAACTCAGGCAGAAATTCGAGAAAGCCAAACTT
GGCCCTGCTGGCAACAAAGTCATCAGTCCCTCTGAAGACAGGAAACAACCTTCCAACAACCTTGACCGAGTGAAACTCACGGACTTCAAT
TTCCTCATGGTGTTGGGAAAGGGGAGTTTTGGAAAGGTGATGCTTGCCGACAGGAAGGGCACAGAAGAACTGTATGCAATCAAAATCCTG
AAGAAGGATGTGGTGATTCAGGATGATGACGTGGAGTGCACCATGGTAGAAAAGCGAGTCTTGGCCCTGCTTGACAAACCCCCGTTCTTG
ACGCAGCTGCACTCCTGCTTCCAGACAGTGGATCGGCTGTACTTCGTCATGGAATATGTCAACGGTGGGGACCTCATGTACCACATTCAG
CAAGTAGGAAAATTTAAGGAACCACAAGCAGTATTCTATGCGGCAGAGATTTCCATCGGATTGTTCTTTCTTCATAAAAGAGGAATCATT
TATAGGGATCTGAAGTTAGATAACGTCATGTTGGATTCAGAAGGACATATCAAAATTGCTGACTTTGGGATGTGCAAGGAACACATGATG
GATGGAGTCACGACCAGGACCTTCTGTGGGACTCCAGATTATATCGCCCCAGAGATAATCGCTTATCAGCCGTATGGAAAATCTGTGGAC
TGGTGGGCCTATGGCGTCCTGTTGTATGAAATGCTTGCCGGGCAGCCTCCATTTGATGGTGAAGATGAAGACGAGCTATTTCAGTCTATC
ATGGAGCACAACGTTTCCTATCCAAAATCCTTGTCCAAGGAGGCTGTTTCTGTCTGCAAAGGACTGATGACCAAACACCCAGCCAAGCGG
CTGGGCTGTGGGCCTGAGGGGGAGAGGGACGTGAGAGAGCATGCCTTCTTCCGGAGGATCGACTGGGAAAAACTGGAGAACAGGGAGATC
CAGCCACCATTCAAGCCCAAAGTGTGTGGCAAAGGAGCAGAGAACTTTGACAAGTTCTTCACACGAGGACAGCCCGTCTTAACACCACCT
GATCAGCTGGTTATTGCTAACATAGACCAGTCTGATTTTGAAGGGTTCTCGTATGTCAACCCCCAGTTTGTGCACCCCATCTTACAGAGT
GCAGTATGAAACTCACCAGCGAGAACAAACACCTCCCCAGCCCCCAGCCCTCCCCGCAGTGGGAAGTGAATCCTTAACCCTAAAATTTTA
AGGCCACGGCCTTGTGTCTGATTCCATATGGAGGCCTGAAAATTGTAGGGTTATTAGTCCAAATGTGATCAACTGTTCAGGGTCTCTCTC
TTACAACCAAGAACATTATCTTAGTGGAAGATGGTACGTCATGCTCAGTGTCCAGTTTAATTCTGTAGAAGTTACGTCTGGCTCTAGGTT
AACCCTTCCTAGAAAGCAAGCAGACTGTTGCCCCATTTTGGGTACAATTTGATATACTTTCCATACCCTCCATCTGTGGATTTTTCAGCA
TTGGAATCCCCCAACCAGAGATGTTAAAGTGAGCCTGTCCCAGGAAACATCTCCACCCAAGACGTCTTTGGAATCCAAGAACAGGAAGCC
AAGAGAGTGAGCAGGGAGGGATTGGGGGTGGGGGAGGCCTCAAAATACCGACTGCGTCCATTCTCTGCCTCCATGGAAACAGCCCCTAGA
ATCTGAAAGGCCGGGATAAACCTAATCACTGTTCCCAAACATTGACAAATCCTAACCCAACCATGGTCCAGCAGTTACCAGTTTAAACAA
AAAAACCTCAGATGAGTGTTGGGTGAATCTGTCATCTGGTACCCTCCTTGGTTGATAACTGTCTTGATACTTTTCATTCTTTGTAAGAGG
CCAAATCGTCTAAGGACGTTGCTGAACAAGCGTGTGAAATCATTTCAGATCAAGGATAAGCCAGTGTGTACATATGTTCATTTTAATCTC
TGGGAGATTATTTTTCCATCCAGGGTGCCATCAGTAATCATGCCACTACTCACCAGTGTTGTTCACCAACACCCACCCCCACACACACCA
ACATTTTGCTGCCTACCTTGTTATCCTTCTCAAGAAGCTGAAGTGTACGCCCTCTCCCCTTTTGTGCTTATTTATTTAATAGGCTGCAGT
GTCGCTTATGAAAGTACGATGTACAGTAACTTAATGGAAGTGCTGACTCTAGCATCAGCCTCTACCGATTGATTTTCCTCCCTTCTCTAG
CCCTGGATGTCCACTTAGGGATAAAAAGAATATGGTTTTGGTTCCCATTTCTAGTTCACGTTGAATGACAGGCCTGGAGCTGTAGAATCA
GGAAACCCGGATGCCTAACAGCTCAAAGATGTTTTGTTAATAGAAGGATTTTAATACGTTTTGCAAATGCATCATGCAATGAATTTTGCA
TGTTTATAATAAACCTTAATAACAAGTGAATCTATATTATTGATATAATCGTATCAAGTATAAAGAGAGTATTATAATAATTTTATAAGA
CACAATTGTGCTCTATTTGTGCAGGTTCTTGTTTCTAATCCTCTTTTCTAATTAAGTTTTAGCTGAATCCCTTGCTTCTGTGCTTTCCCT
CCCTGCACATGGGCACTGTATCAGATAGATTACTTTTTAAATGTAGATAAAATTTCAAAAATGAATGGCTAGTTTACGTGATAGATTAGG
CTCTTACTACATATGTGTGTGTATATATATGTATTTGATTCTACCTGCAAACAAATTTTTATTGGTGAGGACTATTTTTGAGCTGACACT
CCCTCTTAGTTTCTTCATGTCACCTTTCGTCCTGGTTCCTCCGCCACTCTTCCTCTTGGGGACAACAGGAAGTGTCTGATTCCAGTCTGC
CTAGTACGTTGGTACACACGTGGCATTGCCGCAGCACCTGGGCTGACCTTTGTGTGTGCGTGTGTGTGTGTTTCCTTCTTCCCTTCAGCC
TGTGACTGTTGCTGACTCCAGGGGTGGGAGGGATGGGGAGACTCCCCTCTTGCTGTGTGTACTGGACACGCAGGAAGCATGCTGTCTTGC
TGCCTCTGCAACGACCTGTCGTTTGCTCCAGCATGCACAAACTTCGTGAGACCAACACAGCCGTGCCCTGCAGGCACCAGCACGTGCTTT
TCAGAGGCTGCGGACTTTCTTCCAGCCATTGTGGCATTGGCCTTTCCAGTCTTGGGAGGAGCGCGCTGCTTTGGTGAGACACCCCCATGC
AAGGTCCTCAGAGTAGCCGGGTTCTACCACAAACAGAAACAGAATGAAAGTAGCTGTCAGTCCTTGTAGAGAGCCGCTCTGTTTCCTCCC
AGAAGCATCTCCCAGCTAAGCTCGCATTATTTTTCTCCTCTGGCTGTTTGCCTGAAGTTCACAGAACACACAACCATGAAAGGCTTTTTG
AGGTGAGAGGCCCAGGTGGTCCTGGCAACCCTGAGTAGAAGGAGAGACGGGGTAGGGAACGGGCCCGGCCAGAAAAGAACCATTTCTTCT
GCCATCTTTTATGCACCATAGACATCGAGACTCCAGGGGGTCCTGGCTCCCCTGTCCCTGCAGCCCTGCAGGTCAGTGCATGATCTGGGT
TCGTGTCCTGACCAGGTGCTCCTCCTTTGATCCGAGGGGAAAGGGACTGGTTTATAGAAAGAGCCTAGGAGACAAAAGGGCCAGTCCCCC
TGCCCAGAATGGAGCAGCAGCAGGACAGACCCCCACGAGGCCCCCCAGAGAGGAGGAAGATCCCACGGAGGAACACATGAGGTTAGGGAC
CCTTGTTCAGCACCCCAAACAGCCTGCCTGTTTAAAGCAGGCAGCAGGCTTAGGCCTTCCCTGCAACCCCAACACCCACAAGTTTGTTTC
TCTAGGAAACACATTCACTGTCTCAGCTGGCTGTTACTCTCTCAGACCATATGGCAAAGTTTTCCAAGAAAATGCCCCGACAGGGGTGCC
CAGCACACTGCCTGAGGGACAACAGACATCAGAACAAACCCCCAGAGAGAAACAGTCAAAATCAGGGCCCGGTGCAGTGTTGTCATGTGG
AACCTGCTTTATCCATTGCTGAGTGTTGAATGTGGGTAATGGTTAGGGCTTTCCAGATCTCAGCAGCCAAAGACAGTTATTGTTGGAAGA
CTGTCATGTAGATAACCATGAGCAATGGCTCGCCTCAGAATCAGTTCATAAAATTCTATGGTACTGGCCCCTTCGTGGGTATTGTGTGAA
ATGAGATGGTGGCGAGGGGTGCGCTGTGGAACTGCCGCAGCCACGCAGGAGGTCCCTGGGGGATGCTTTGGGAAGTCCTTGCCCCTGAGC
ACTGCCTGATTGCCAGGGCCTGTGGAGGTCTAGGCCGCCTGGCAGAATCTAGCACCGTCCGAATCCCCGCAGGACCCATGGAGCTATGAC
CACACCAGGCCATTCAAATGGCTCTGCATTATCTTCCCTTGGAAGGTGGCCACTCCTCGGTGGCAGGGCCTTTCCCTGAGGCTGCAGGCC
GTGGGCTGGCAGCCCGTCTCTTGGCATTTCAATTGAAGGTCACCAGGTGCTGGGTTTGAAAGGAAGTCACTGGAGTGCTGCCAGGGGCCG
CCCTCCAAGGTTAATGAGAGGCCCACATCCAGGCAAGAACTAATTCAAAAGGCAGATCAGAAACCACAGGAGTCAAAATTATTGCTCCGG
CAGTGCTTCCCTTCCTTTCATCCACTGGCCTCGTGTGGTCCATGCAGGGCCACTGTCTGCCCTTTCTGATGCCACGTATTAGGCTTTCTT
ACTCAGAATTTTGATAGAAAACCATGGGGCCAAGAGCTCTGGAAGCCTGGCCGGAAAGACCAAGGTTCATGCAGCCCAACAAATGATTGT
TGAGCACCTCTCGGAGCCAAAGTCCTTAGGCGAGTGTGGTGACTTCCTGGAAGGAGGATGCAGACTTCCAGAGAGCCCCCCCAACGGACG
TGCTGAGAAGGGAGAGGGAGGCGGGGGCTGTAGTCAGGAAGGAGCCAGAGAAGAACAGGGTTTGGGTGCATCCAGAAATATGCCTGCAGT
AGGAGGGAGAGGAAGGGGTGCCACCGTCAACGGCTTCCCATCGGAGGTGGTTGGTGCAGATGGAAGTTTCTGTCTGCTGGCCCTCAAGAG
AGTGTTTTGCCAGGGACACAGTCTGTTCCTCCTCAGAAAACACCCCCCAAATGCTAACAACATCCCCACCAGCTGCTAGAAGCCCCTTTC
CCCTCCCCACCTTGAAGTAGCTCATAGTTCTCTGGGCAGAGCCAGACCATCCAGTGTACCCCAGAGGCCAGTAGGTTCCTGCCCATTTTC
CTCTCTGGCTTCCTGCCAAGAATTATGGCAGCTGAGGATGAATGGAGAAGTAAAAACAACTAACACCGCACAACTAACAACTAACACCGC
AGTTCCCACCTGGGTTCCACTTAGCAGGAGACATTTCGGAGGGTTTTTTTTGTTTTTGTTCCTGTTTTTTTTTTTTTTGCTGGAATTTGT
TTTCTCAGTACTGAAAAGAGAAAAAGTGACAATCTTGTATTTTTAAAAGCCTCGGAAAGGTGATACCATCTGACAGTCATTTTCTCACGT
TGGTCTTCTAAAGTCACCTATTTCTTGTGTGTGCACATCACACCATTTCCTGTTTCTTTATAACCCGACAAGGGTAGGAGTGCCTGTTTC
CCCTGCTGGGCACACCAGACAATCGTAATCACAAAACAGACACTGAGCCAGGGGCCCAAAGGGTGTGATCATGAGAGTTACCGGGACAGC
AGTAGGCATGACAGTCACCAGGAAGGACAAGGGTGCTCTGTTGTTAGTGGCCACACACCAATTTGACAAGGAGTGTTGCGAAATTTTTAT
TTATTTATTTATTTATTTTGAGATGGAGTTTCACTCTTGTTGCCCAGGCTGGAGTGCGGTGGTACAATCTCGGCTCACTGCAACCTCCAC
CTCCCAGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCAAGTACCTGGGACTACAGGTGCGTGCCACCACACCCAGCTAAATTTTGTGTTT
TTAGTAGAGATGGGGTTTCACCATGTTGGCCAGGATGGTCTTGAACCCCTGACCTCATGATCTGCCTGCCTCGGCCTCCCAAAGTGCTGG
GATTACAGGCATGAGCCACCACGCCCAGCCAAAATATTTTTTTAAAGTCATTTTCCTTAAGCTGCTTGGGCTACATGTGAAATACACTGG
ACGGTCAACATTCCTGTCTCCTCCCATTTGGGCTGATGCAGCAGATCCAGGGAATGTTACCTGTTTCTGCTGCTAGAAGATCCAGGAAAT
TGGGAAGGTTACCTGACGCACACATGGATGAAGGCCATCATCTAGAAATGGGGTCAACCACAATTGTGTTAATTCCGTAGTGTCAGGGAT
TCTTCGGGAAGGTCAACAGTATGAAGGATTCTGACCCCTGTGCCTCCCATTTATGTGATCAGGTGACAGTTAATAACCGTGGAGGTCACA
CTCAGCCATCCAACAGCCTTACAGTGACCCTACACAAAAGCCCCCAAATTCCAAAGACTTTTTCTTAACCTAAAGGAAGAAATTATTTGT
TAATTCCAGTAGAGCAACTGAATATACTGGGCTATTTGTACTTTTTTATAGAGAACTTTAATAATAATTCTTTAAAAATGAGTTTTTAGA
ACAAAGCAACTGACGATTTCCTAAGATTCCAATGCCCTGGAGCTTGTAGGAGGACTTAGCCTGGGTCAGCTGGAGCACCCCCGACCTGAT
CTCCCACTGCCAGATTTTCCCATGCTCCTAGGGTATGGAGTCCACGTGGGAATGACTGCAAGTTCAGGTGGAACTTGGCCGACTGATGCT
CTGCGAGTTTTTAATAGACACTGGGGACAACTGCTTAAGGTTTAGAAACTTCCAAACCACAGGAAAGACATTTTTAGTGTCCCCCATCCA
GAGGCAGCCCTGGAATAGGATTCCCAGGGGTTTCTGGGACCCCTTTCCTTGCTCCGTGAGGCTCTGTGGCCATCTTTTGGCAGGAGGAGG
ATGCTTCCTTGGCTCTGTGCCCAGACCCGCCTGGTCCCCAGGTCTCTCACCTTGGGTGAAGATTCAGAGATGCCCTGTAAGGATTTTGCC
CACTGGGCAACTCAGAAATACTTCGATCTCCCAAGATATAAGAGGCAGCAGCAAACGTGCCTATTGACGTCTGTTTCATAGTTACCACTT
ACGCGAGTAGACAGAACTCGGCTTTTCAGAAAATAGGTGTCAAGTCCACTTTATAAGAACCTTTTTTTCTAAAATAAGATAAAAGGTGGC
TTTGCATTTTCTGATTAAACGACTGTGTCTTTGTCACCTCTGCTTAACTTTAGGAGTATCCATTCCTGTGATTGTAGACTTTTGTTGATA
TTCTTCCTGGAAGAATATCATTCTTTTCTTGAAGGGTTGGTTTACTAGAATATTCAAAATCAATCATGAAGGCAGTTACTATTTTGAGTC
TAAAGGTTTTCTAAAAATTAACCTCACATCCCTTCTGTTAGGGTCTTTCAGAATATCTTTTATAAACAGAAGCATTTGAAGTCATTGCTT
TTGCTACATGATTTGTGTGTGTGAAGGACATACCACGTTTAAATCATTAATTGAAAAACATCATATAAGCCCCAACTTTGTTTGGAGGAA
GAGACGGAGGTTGAGGTTTTTCCTTCTGTATAAGCACCTACTGACAAAATGTAGAGGCCATTCAACCGTCAAACACCATTTGGTTATATC
GCAGAGGAGACGGATGTGTAAATTACTGCATTGCTTTTTTTTTCAGTTTGTATAACCTCTAATCTCCGTTTGCATGATACGCTTTGTTAG


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FusionGenePPI for TANC2_PRKCA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
TANC2LATS2, YWHAB, PPP1CC, PPP1CA, XPO1, NR2C2, BRAP, CDC5L, ZYX, PAK7, KCTD3, KIF13B, CGN, ZBTB21, KSR1, GIGYF1, LPIN3, MAPRE1, LRFN1, RTKN, DENND4C, MAST3, SH3RF3, DENND1A, SH3PXD2A, SRGAP2, PPM1H, PTPN13, RALGPS2, EIF4E2, SIPA1L1, NF1, CDC25C, CBY1, GIGYF2, INPP5EPRKCAATP1A1, HABP4, HAND1, HAND2, FSCN1, EGFR, SLC1A1, PLD1, KLF5, GABRB3, MGMT, PLD2, PICK1, GRM7, AKAP12, GJA1, YWHAG, C1QBP, AVPR1A, AVPR1B, GSK3B, RGS2, OGG1, YWHAZ, TIAM1, GNB2L1, ITGB1, AFAP1, EZR, DLG4, LMNB1, LMNA, CD53, CD9, TRIM41, HMGA1, HMGA2, TNP1, TNP2, HIST1H3A, CHUK, IKBKB, NFE2L2, PRKCA, MTOR, TRPV6, AKAP5, DDX58, HIST1H1A, HIST1H1B, HIST1H1C, HIST1H1D, HIST1H1E, HIST1H1T, EIF4EBP1, MBP, HDAC6, CTNNB1, NR1H2, ELAVL1, HIST3H3, ANXA6, LNX1, LNX2, GLI3, IBTK, SCRIB, CBL, TOP2A, RICTOR, MAPKAP1, SELL, PFKFB1, NCF1, ACIN1, DSP, RALBP1, PPP1R14A, PLCG2, VTN, SDC2, ITGB2, HSP90AA1, GSK3A, GRIN1, GRIN2B, CASR, RRAD, NFKBIA, HMGN1, HMGN2, NPM1, NUMB, FBXO25, CDKN2A, PSMB4, SACM1L, PTGIR, TBXA2R, CYP3A4, RBCK1, RNF31, MOV10, NXF1, EP300, PPARG, CCDC8, EIF2S1, SLC25A41, SLC25A11, TAS2R7, TMEM185A, JSRP1, CCNL2, VPS4B, UQCRB, WWC2, WWC3, WWC1, MAPK7, NTRK1, NOXA1, GRM5, AKAP13, STXBP1, SPAG1, BTG2, CACYBP, SLC9A3R1, SLC9A3R2, KIF2A, KIF11, FAS, NF2, PLA2G4A, SMURF1, PRKCB, PRKCG, PRKCH, PIP5K1A, SHCBP1, GCLM, STARD7, CYP2S1, FGD4, DUSP11, FBXO21, HR, PPM1A, ATM, TES


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for TANC2_PRKCA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePRKCAP17252DB00675TamoxifenProtein kinase C alpha typesmall moleculeapproved
TgenePRKCAP17252DB05013Ingenol MebutateProtein kinase C alpha typesmall moleculeapproved

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RelatedDiseases for TANC2_PRKCA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePRKCAC0036341Schizophrenia2PSYGENET
TgenePRKCAC0011853Diabetes Mellitus, Experimental1CTD_human
TgenePRKCAC0018800Cardiomegaly1CTD_human
TgenePRKCAC0021841Intestinal Neoplasms1CTD_human
TgenePRKCAC0032617Polyuria1CTD_human
TgenePRKCAC0033975Psychotic Disorders1PSYGENET
TgenePRKCAC0036337Schizoaffective Disorder1PSYGENET
TgenePRKCAC0162283Nephrogenic Diabetes Insipidus1CTD_human
TgenePRKCAC0349204Nonorganic psychosis1PSYGENET