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Fusion gene ID: 37167 |
FusionGeneSummary for TANC2_ARHGEF12 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TANC2_ARHGEF12 | Fusion gene ID: 37167 | Hgene | Tgene | Gene symbol | TANC2 | ARHGEF12 | Gene ID | 26115 | 23365 |
| Gene name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 | Rho guanine nucleotide exchange factor 12 | |
| Synonyms | ROLSA|rols | LARG|PRO2792 | |
| Cytomap | 17q23.2-q23.3 | 11q23.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein TANC2putative ankyrin-repeat containing proteinrolling pebbles homolog Btetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2 | rho guanine nucleotide exchange factor 12Rho guanine nucleotide exchange factor (GEF) 12leukemia-associated RhoGEFleukemia-associated rho guanine nucleotide exchange factor | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q9HCD6 | Q9NZN5 | |
| Ensembl transtripts involved in fusion gene | ENST00000424789, ENST00000389520, | ENST00000397843, ENST00000356641, ENST00000532993, | |
| Fusion gene scores | * DoF score | 26 X 12 X 11=3432 | 3 X 3 X 2=18 |
| # samples | 27 | 4 | |
| ** MAII score | log2(27/3432*10)=-3.66801824044871 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: TANC2 [Title/Abstract] AND ARHGEF12 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Oncogene involved fusion gene, in-frame and retained their domain. Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. Tumor suppressor gene involved fusion gene, retained protein feature but frameshift. DDR (DNA damage repair) gene involved fusion gene, in-frame but not retained their domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | ARHGEF12 | GO:0007186 | G-protein coupled receptor signaling pathway | 15755723 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-FX-A2QS-01A | TANC2 | chr17 | 61151375 | + | ARHGEF12 | chr11 | 120317112 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000424789 | ENST00000397843 | TANC2 | chr17 | 61151375 | + | ARHGEF12 | chr11 | 120317112 | + |
| In-frame | ENST00000424789 | ENST00000356641 | TANC2 | chr17 | 61151375 | + | ARHGEF12 | chr11 | 120317112 | + |
| In-frame | ENST00000424789 | ENST00000532993 | TANC2 | chr17 | 61151375 | + | ARHGEF12 | chr11 | 120317112 | + |
| In-frame | ENST00000389520 | ENST00000397843 | TANC2 | chr17 | 61151375 | + | ARHGEF12 | chr11 | 120317112 | + |
| In-frame | ENST00000389520 | ENST00000356641 | TANC2 | chr17 | 61151375 | + | ARHGEF12 | chr11 | 120317112 | + |
| In-frame | ENST00000389520 | ENST00000532993 | TANC2 | chr17 | 61151375 | + | ARHGEF12 | chr11 | 120317112 | + |
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FusionProtFeatures for TANC2_ARHGEF12 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TANC2 | ARHGEF12 |