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Fusion gene ID: 37159 |
FusionGeneSummary for TANC1_MAML2 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TANC1_MAML2 | Fusion gene ID: 37159 | Hgene | Tgene | Gene symbol | TANC1 | MAML2 | Gene ID | 85461 | 84441 |
| Gene name | tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 1 | mastermind like transcriptional coactivator 2 | |
| Synonyms | ROLSB|TANC | MAM-3|MAM2|MAM3|MLL-MAML2 | |
| Cytomap | 2q24.2 | 11q21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein TANC1TPR domain, ankyrin-repeat and coiled-coil-containingrolling pebbles homolog Btetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 1 | mastermind-like protein 2mam-2mastermind-like 2 | |
| Modification date | 20180519 | 20180523 | |
| UniProtAcc | Q9C0D5 | Q8IZL2 | |
| Ensembl transtripts involved in fusion gene | ENST00000454300, ENST00000263635, | ENST00000524717, | |
| Fusion gene scores | * DoF score | 7 X 8 X 5=280 | 10 X 12 X 4=480 |
| # samples | 10 | 16 | |
| ** MAII score | log2(10/280*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(16/480*10)=-1.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TANC1 [Title/Abstract] AND MAML2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | MAML2 | GO:0007219 | Notch signaling pathway | 12370315 |
| Tgene | MAML2 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12370315 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AW889440 | TANC1 | chr2 | 160057518 | + | MAML2 | chr11 | 96021383 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-intron | ENST00000454300 | ENST00000524717 | TANC1 | chr2 | 160057518 | + | MAML2 | chr11 | 96021383 | + |
| intron-intron | ENST00000263635 | ENST00000524717 | TANC1 | chr2 | 160057518 | + | MAML2 | chr11 | 96021383 | + |
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FusionProtFeatures for TANC1_MAML2 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TANC1 | MAML2 |