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Fusion gene ID: 37134 |
FusionGeneSummary for TAF8_SLC22A16 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAF8_SLC22A16 | Fusion gene ID: 37134 | Hgene | Tgene | Gene symbol | TAF8 | SLC22A16 | Gene ID | 129685 | 85413 |
| Gene name | TATA-box binding protein associated factor 8 | solute carrier family 22 member 16 | |
| Synonyms | II|TAF|TAFII-43|TAFII43|TBN | CT2|FLIPT2|HEL-S-18|OAT6|OCT6|OKB1|dJ261K5.1 | |
| Cytomap | 6p21.1 | 6q21|6q21-q22.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transcription initiation factor TFIID subunit 8TAF(II)43TAF8 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 43kDaTATA box binding protein (TBP)-associated factor, RNA polymerase II, A, 45/50kDaTBP-associated factor 43 kDaTBP-ass | solute carrier family 22 member 16WUGSC:RG331P03.1carnitine transporter 2epididymis secretory protein Li 18flipt 2fly-like putative organic ion transporter 2fly-like putative transporter 2organic cation transporter 6organic cation transporter OKB1 | |
| Modification date | 20180522 | 20180522 | |
| UniProtAcc | Q7Z7C8 | Q86VW1 | |
| Ensembl transtripts involved in fusion gene | ENST00000372978, ENST00000494547, ENST00000456846, ENST00000372982, ENST00000472818, ENST00000372977, ENST00000482926, ENST00000465926, ENST00000482432, | ENST00000368919, ENST00000330550, ENST00000439654, ENST00000456137, ENST00000461487, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 5 X 3 X 5=75 |
| # samples | 9 | 6 | |
| ** MAII score | log2(9/252*10)=-1.48542682717024 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAF8 [Title/Abstract] AND SLC22A16 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | TAF8 | GO:0045598 | regulation of fat cell differentiation | 14580349 |
| Hgene | TAF8 | GO:0045893 | positive regulation of transcription, DNA-templated | 14580349 |
| Hgene | TAF8 | GO:0051457 | maintenance of protein location in nucleus | 15870280 |
| Tgene | SLC22A16 | GO:0015695 | organic cation transport | 12089149|15963465 |
| Tgene | SLC22A16 | GO:0015879 | carnitine transport | 12089149 |
| Tgene | SLC22A16 | GO:0046717 | acid secretion | 12089149 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-43-A475-01A | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000372978 | ENST00000368919 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000372978 | ENST00000330550 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000372978 | ENST00000439654 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000372978 | ENST00000456137 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000372978 | ENST00000461487 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000494547 | ENST00000368919 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000494547 | ENST00000330550 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000494547 | ENST00000439654 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000494547 | ENST00000456137 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000494547 | ENST00000461487 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000456846 | ENST00000368919 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000456846 | ENST00000330550 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000456846 | ENST00000439654 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000456846 | ENST00000456137 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000456846 | ENST00000461487 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000372982 | ENST00000368919 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000372982 | ENST00000330550 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000372982 | ENST00000439654 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000372982 | ENST00000456137 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000372982 | ENST00000461487 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000472818 | ENST00000368919 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000472818 | ENST00000330550 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000472818 | ENST00000439654 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000472818 | ENST00000456137 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000472818 | ENST00000461487 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000372977 | ENST00000368919 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000372977 | ENST00000330550 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000372977 | ENST00000439654 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000372977 | ENST00000456137 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000372977 | ENST00000461487 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 3UTR-3CDS | ENST00000482926 | ENST00000368919 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 3UTR-3CDS | ENST00000482926 | ENST00000330550 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 3UTR-3CDS | ENST00000482926 | ENST00000439654 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 3UTR-3UTR | ENST00000482926 | ENST00000456137 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 3UTR-intron | ENST00000482926 | ENST00000461487 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000465926 | ENST00000368919 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000465926 | ENST00000330550 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000465926 | ENST00000439654 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000465926 | ENST00000456137 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000465926 | ENST00000461487 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000482432 | ENST00000368919 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000482432 | ENST00000330550 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| Frame-shift | ENST00000482432 | ENST00000439654 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-3UTR | ENST00000482432 | ENST00000456137 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
| 5CDS-intron | ENST00000482432 | ENST00000461487 | TAF8 | chr6 | 42023752 | + | SLC22A16 | chr6 | 110763978 | - |
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FusionProtFeatures for TAF8_SLC22A16 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAF8 | SLC22A16 |