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Fusion gene ID: 37083 |
FusionGeneSummary for TAF1A_SLC12A7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TAF1A_SLC12A7 | Fusion gene ID: 37083 | Hgene | Tgene | Gene symbol | TAF1A | SLC12A7 | Gene ID | 9015 | 10723 |
| Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit A | solute carrier family 12 member 7 | |
| Synonyms | MGC:17061|RAFI48|SL1|TAFI48 | KCC4 | |
| Cytomap | 1q41 | 5p15.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | TATA box-binding protein-associated factor RNA polymerase I subunit ARNA polymerase I-specific TBP-associated factor 48 kDaSL1, 48kD subunitTATA box binding protein (TBP)-associated factor, RNA polymerase I, A, 48kDTATA box binding protein (TBP)-assoc | solute carrier family 12 member 7K-Cl cotransporter 4SUCO/SLC12A7 fusionelectroneutral potassium-chloride cotransporter 4potassium/chloride transporter KCC4solute carrier family 12 (potassium/chloride transporter), member 7solute carrier family 12 ( | |
| Modification date | 20180522 | 20180523 | |
| UniProtAcc | Q15573 | Q9Y666 | |
| Ensembl transtripts involved in fusion gene | ENST00000366890, ENST00000350027, ENST00000352967, ENST00000391882, ENST00000543857, ENST00000465263, | ENST00000264930, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 4 X 4 X 4=64 |
| # samples | 2 | 4 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(4/64*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TAF1A [Title/Abstract] AND SLC12A7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | HNSC | TCGA-DQ-7589-01A | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000366890 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| Frame-shift | ENST00000350027 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| In-frame | ENST00000352967 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| intron-3CDS | ENST00000391882 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| In-frame | ENST00000543857 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
| 5UTR-3CDS | ENST00000465263 | ENST00000264930 | TAF1A | chr1 | 222757470 | - | SLC12A7 | chr5 | 1085588 | - |
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FusionProtFeatures for TAF1A_SLC12A7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TAF1A | SLC12A7 |