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Fusion gene ID: 37048 |
FusionGeneSummary for TACC3_TMEM129 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TACC3_TMEM129 | Fusion gene ID: 37048 | Hgene | Tgene | Gene symbol | TACC3 | TMEM129 | Gene ID | 10460 | 92305 |
| Gene name | transforming acidic coiled-coil containing protein 3 | transmembrane protein 129 | |
| Synonyms | ERIC-1|ERIC1 | D4S2561E | |
| Cytomap | 4p16.3 | 4p16.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transforming acidic coiled-coil-containing protein 3 | E3 ubiquitin-protein ligase TM129RING-type E3 ubiquitin transferase TM129transmembrane protein 129, E3 ubiquitin protein ligase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9Y6A5 | A0AVI4 | |
| Ensembl transtripts involved in fusion gene | ENST00000313288, | ENST00000303277, ENST00000382936, ENST00000536901, | |
| Fusion gene scores | * DoF score | 2 X 5 X 5=50 | 2 X 1 X 2=4 |
| # samples | 5 | 2 | |
| ** MAII score | log2(5/50*10)=0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: TACC3 [Title/Abstract] AND TMEM129 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | TMEM129 | GO:0000209 | protein polyubiquitination | 24807418 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SKCM | TCGA-D3-A8GR-06A | TACC3 | chr4 | 1739429 | + | TMEM129 | chr4 | 1720353 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000313288 | ENST00000303277 | TACC3 | chr4 | 1739429 | + | TMEM129 | chr4 | 1720353 | - |
| Frame-shift | ENST00000313288 | ENST00000382936 | TACC3 | chr4 | 1739429 | + | TMEM129 | chr4 | 1720353 | - |
| Frame-shift | ENST00000313288 | ENST00000536901 | TACC3 | chr4 | 1739429 | + | TMEM129 | chr4 | 1720353 | - |
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FusionProtFeatures for TACC3_TMEM129 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TACC3 | TMEM129 |