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Fusion gene ID: 37043 |
FusionGeneSummary for TACC2_MRFAP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TACC2_MRFAP1 | Fusion gene ID: 37043 | Hgene | Tgene | Gene symbol | TACC2 | MRFAP1 | Gene ID | 10579 | 93621 |
| Gene name | transforming acidic coiled-coil containing protein 2 | Morf4 family associated protein 1 | |
| Synonyms | AZU-1|ECTACC | PAM14|PGR1 | |
| Cytomap | 10q26.13 | 4p16.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transforming acidic coiled-coil-containing protein 2anti zuai-1 | MORF4 family-associated protein 1Mof4 family associated protein 1T-cell activation proteinprotein associated with MRG of 14 kDa | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | O95359 | Q9Y605 | |
| Ensembl transtripts involved in fusion gene | ENST00000369005, ENST00000513429, ENST00000515273, ENST00000515603, ENST00000453444, ENST00000358010, ENST00000334433, ENST00000369001, ENST00000369000, ENST00000360561, ENST00000368999, ENST00000369004, ENST00000260733, ENST00000493951, | ENST00000320912, ENST00000507420, ENST00000382581, | |
| Fusion gene scores | * DoF score | 9 X 9 X 6=486 | 6 X 5 X 4=120 |
| # samples | 12 | 6 | |
| ** MAII score | log2(12/486*10)=-2.01792190799726 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TACC2 [Title/Abstract] AND MRFAP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | AA232632 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000369005 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-intron | ENST00000369005 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000369005 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000513429 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-intron | ENST00000513429 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000513429 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-3UTR | ENST00000515273 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-intron | ENST00000515273 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-3UTR | ENST00000515273 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-3UTR | ENST00000515603 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-intron | ENST00000515603 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-3UTR | ENST00000515603 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-3UTR | ENST00000453444 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-intron | ENST00000453444 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-3UTR | ENST00000453444 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000358010 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-intron | ENST00000358010 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000358010 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000334433 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-intron | ENST00000334433 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000334433 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000369001 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-intron | ENST00000369001 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000369001 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000369000 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-intron | ENST00000369000 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000369000 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000360561 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-intron | ENST00000360561 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000360561 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000368999 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-intron | ENST00000368999 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000368999 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000369004 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-intron | ENST00000369004 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000369004 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000260733 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-intron | ENST00000260733 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| 3UTR-3UTR | ENST00000260733 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-3UTR | ENST00000493951 | ENST00000320912 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-intron | ENST00000493951 | ENST00000507420 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
| intron-3UTR | ENST00000493951 | ENST00000382581 | TACC2 | chr10 | 124013892 | - | MRFAP1 | chr4 | 6644139 | - |
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FusionProtFeatures for TACC2_MRFAP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TACC2 | MRFAP1 |