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Fusion gene ID: 37036 |
FusionGeneSummary for TACC1_RAB11FIP1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: TACC1_RAB11FIP1 | Fusion gene ID: 37036 | Hgene | Tgene | Gene symbol | TACC1 | RAB11FIP1 | Gene ID | 6867 | 80223 |
| Gene name | transforming acidic coiled-coil containing protein 1 | RAB11 family interacting protein 1 | |
| Synonyms | Ga55 | NOEL1A|RCP|rab11-FIP1 | |
| Cytomap | 8p11.22 | 8p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | transforming acidic coiled-coil-containing protein 1gastric cancer antigen Ga55taxin-1 | rab11 family-interacting protein 1RAB11 coupling proteinRAB11 family interacting protein 1 (class I)Rab effector proteinRab-interacting recycling protein | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | O75410 | Q6WKZ4 | |
| Ensembl transtripts involved in fusion gene | ENST00000519416, ENST00000520615, ENST00000443286, ENST00000520340, ENST00000518415, ENST00000522752, ENST00000348567, ENST00000330691, ENST00000317827, ENST00000379931, ENST00000276520, ENST00000520973, ENST00000520611, | ENST00000287263, ENST00000330843, ENST00000522727, ENST00000523182, ENST00000524118, | |
| Fusion gene scores | * DoF score | 6 X 6 X 5=180 | 10 X 7 X 6=420 |
| # samples | 8 | 12 | |
| ** MAII score | log2(8/180*10)=-1.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/420*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: TACC1 [Title/Abstract] AND RAB11FIP1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | RAB11FIP1 | GO:0070164 | negative regulation of adiponectin secretion | 24040321 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BLCA | TCGA-K4-A6FZ-01A | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000519416 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000519416 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000519416 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000519416 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000519416 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| In-frame | ENST00000520615 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000520615 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000520615 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000520615 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000520615 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| In-frame | ENST00000443286 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000443286 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000443286 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000443286 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000443286 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| In-frame | ENST00000520340 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000520340 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000520340 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000520340 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000520340 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| In-frame | ENST00000518415 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000518415 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000518415 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000518415 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000518415 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 3UTR-3CDS | ENST00000522752 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 3UTR-3CDS | ENST00000522752 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 3UTR-3CDS | ENST00000522752 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 3UTR-5UTR | ENST00000522752 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 3UTR-intron | ENST00000522752 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| In-frame | ENST00000348567 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000348567 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000348567 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000348567 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000348567 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| In-frame | ENST00000330691 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000330691 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000330691 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000330691 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000330691 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| In-frame | ENST00000317827 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000317827 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000317827 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000317827 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000317827 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| In-frame | ENST00000379931 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000379931 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000379931 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000379931 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000379931 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| In-frame | ENST00000276520 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000276520 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000276520 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000276520 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000276520 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| In-frame | ENST00000520973 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000520973 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| Frame-shift | ENST00000520973 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-5UTR | ENST00000520973 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| 5CDS-intron | ENST00000520973 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| intron-3CDS | ENST00000520611 | ENST00000287263 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| intron-3CDS | ENST00000520611 | ENST00000330843 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| intron-3CDS | ENST00000520611 | ENST00000522727 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| intron-5UTR | ENST00000520611 | ENST00000523182 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
| intron-intron | ENST00000520611 | ENST00000524118 | TACC1 | chr8 | 38682886 | + | RAB11FIP1 | chr8 | 37720631 | - |
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FusionProtFeatures for TACC1_RAB11FIP1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| TACC1 | RAB11FIP1 |