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Fusion gene ID: 36981 |
FusionGeneSummary for SYT1_EPYC |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYT1_EPYC | Fusion gene ID: 36981 | Hgene | Tgene | Gene symbol | SYT1 | EPYC | Gene ID | 6857 | 1833 |
| Gene name | synaptotagmin 1 | epiphycan | |
| Synonyms | P65|SVP65|SYT | DSPG3|PGLB|Pg-Lb|SLRR3B | |
| Cytomap | 12q21.2 | 12q21.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | synaptotagmin-1synaptotagmin IsytI | epiphycandermatan sulfate proteoglycan 3epiphycan proteoglycanproteoglycan-lbsmall chondroitin/dermatan sulfate proteoglycan | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P21579 | Q99645 | |
| Ensembl transtripts involved in fusion gene | ENST00000393240, ENST00000261205, ENST00000457153, ENST00000552744, ENST00000549454, | ENST00000261172, | |
| Fusion gene scores | * DoF score | 9 X 6 X 3=162 | 8 X 4 X 4=128 |
| # samples | 10 | 7 | |
| ** MAII score | log2(10/162*10)=-0.6959938131099 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(7/128*10)=-0.870716983055034 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SYT1 [Title/Abstract] AND EPYC [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SYT1 | GO:1903861 | positive regulation of dendrite extension | 23999003 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-SG-A6Z7-01A | SYT1 | chr12 | 79441142 | + | EPYC | chr12 | 91396355 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-5UTR | ENST00000393240 | ENST00000261172 | SYT1 | chr12 | 79441142 | + | EPYC | chr12 | 91396355 | - |
| 5UTR-5UTR | ENST00000261205 | ENST00000261172 | SYT1 | chr12 | 79441142 | + | EPYC | chr12 | 91396355 | - |
| intron-5UTR | ENST00000457153 | ENST00000261172 | SYT1 | chr12 | 79441142 | + | EPYC | chr12 | 91396355 | - |
| 5UTR-5UTR | ENST00000552744 | ENST00000261172 | SYT1 | chr12 | 79441142 | + | EPYC | chr12 | 91396355 | - |
| 3UTR-5UTR | ENST00000549454 | ENST00000261172 | SYT1 | chr12 | 79441142 | + | EPYC | chr12 | 91396355 | - |
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FusionProtFeatures for SYT1_EPYC |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYT1 | EPYC |