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Fusion gene ID: 36971 |
FusionGeneSummary for SYT12_SH3GLB1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYT12_SH3GLB1 | Fusion gene ID: 36971 | Hgene | Tgene | Gene symbol | SYT12 | SH3GLB1 | Gene ID | 91683 | 51100 |
| Gene name | synaptotagmin 12 | SH3 domain containing GRB2 like, endophilin B1 | |
| Synonyms | SYT11|sytXII | Bif-1|CGI-61|PPP1R70|dJ612B15.2 | |
| Cytomap | 11q13.2 | 1p22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | synaptotagmin-12synaptotagmin-XII | endophilin-B1Bax-interacting factor 1SH3 domain-containing GRB2-like protein B1SH3-containing protein SH3GLB1SH3-domain GRB2 like endophilin B1protein phosphatase 1, regulatory subunit 70testicular tissue protein Li 172 | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | Q8IV01 | Q9Y371 | |
| Ensembl transtripts involved in fusion gene | ENST00000393946, ENST00000525457, ENST00000527043, ENST00000526281, | ENST00000370558, ENST00000535010, ENST00000482504, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(4/18*10)=1.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SYT12 [Title/Abstract] AND SH3GLB1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | SH3GLB1 | GO:0032461 | positive regulation of protein oligomerization | 19074440 |
| Tgene | SH3GLB1 | GO:0051259 | protein complex oligomerization | 19805544 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | BF995061 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - | ||
| ChiTaRS3.1 | BF995206 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3UTR | ENST00000393946 | ENST00000370558 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-intron | ENST00000393946 | ENST00000535010 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-intron | ENST00000393946 | ENST00000482504 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-3UTR | ENST00000525457 | ENST00000370558 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-intron | ENST00000525457 | ENST00000535010 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-intron | ENST00000525457 | ENST00000482504 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-3UTR | ENST00000527043 | ENST00000370558 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-intron | ENST00000527043 | ENST00000535010 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-intron | ENST00000527043 | ENST00000482504 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-3UTR | ENST00000526281 | ENST00000370558 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-intron | ENST00000526281 | ENST00000535010 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
| intron-intron | ENST00000526281 | ENST00000482504 | SYT12 | chr11 | 66802087 | - | SH3GLB1 | chr1 | 87210438 | - |
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FusionProtFeatures for SYT12_SH3GLB1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYT12 | SH3GLB1 |