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Fusion gene ID: 36952 |
FusionGeneSummary for SYNRG_FBXO47 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYNRG_FBXO47 | Fusion gene ID: 36952 | Hgene | Tgene | Gene symbol | SYNRG | FBXO47 | Gene ID | 11276 | 494188 |
| Gene name | synergin gamma | F-box protein 47 | |
| Synonyms | AP1GBP1|SYNG | - | |
| Cytomap | 17q12 | 17q12|17q12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | synergin gammaAP1 gamma subunit binding protein 1AP1 subunit gamma-binding protein 1adaptor-related protein complex 1 gamma subunit-binding protein 1gamma-synergin | F-box only protein 47 | |
| Modification date | 20180519 | 20180329 | |
| UniProtAcc | Q9UMZ2 | Q5MNV8 | |
| Ensembl transtripts involved in fusion gene | ENST00000339208, ENST00000346661, ENST00000345615, ENST00000502449, ENST00000591288, ENST00000394378, ENST00000585472, ENST00000588194, | ENST00000378079, | |
| Fusion gene scores | * DoF score | 14 X 15 X 9=1890 | 5 X 5 X 3=75 |
| # samples | 17 | 5 | |
| ** MAII score | log2(17/1890*10)=-3.47477958297073 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/75*10)=-0.584962500721156 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SYNRG [Title/Abstract] AND FBXO47 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-KK-A5A1-01A | SYNRG | chr17 | 35969327 | - | FBXO47 | chr17 | 37107942 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000339208 | ENST00000378079 | SYNRG | chr17 | 35969327 | - | FBXO47 | chr17 | 37107942 | - |
| In-frame | ENST00000346661 | ENST00000378079 | SYNRG | chr17 | 35969327 | - | FBXO47 | chr17 | 37107942 | - |
| In-frame | ENST00000345615 | ENST00000378079 | SYNRG | chr17 | 35969327 | - | FBXO47 | chr17 | 37107942 | - |
| In-frame | ENST00000502449 | ENST00000378079 | SYNRG | chr17 | 35969327 | - | FBXO47 | chr17 | 37107942 | - |
| In-frame | ENST00000591288 | ENST00000378079 | SYNRG | chr17 | 35969327 | - | FBXO47 | chr17 | 37107942 | - |
| In-frame | ENST00000394378 | ENST00000378079 | SYNRG | chr17 | 35969327 | - | FBXO47 | chr17 | 37107942 | - |
| In-frame | ENST00000585472 | ENST00000378079 | SYNRG | chr17 | 35969327 | - | FBXO47 | chr17 | 37107942 | - |
| intron-3CDS | ENST00000588194 | ENST00000378079 | SYNRG | chr17 | 35969327 | - | FBXO47 | chr17 | 37107942 | - |
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FusionProtFeatures for SYNRG_FBXO47 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYNRG | FBXO47 |