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Fusion gene ID: 36936

FusionGeneSummary for SYNJ2_KIF25

Fusion gene summary

Fusion gene information	Fusion gene name: SYNJ2_KIF25
	Fusion gene ID: 36936
		Hgene	Tgene
	Gene symbol	SYNJ2	KIF25
	Gene ID	8871	3834
	Gene name	synaptojanin 2	kinesin family member 25
	Synonyms	INPP5H	KNSL3
	Cytomap	6q25.3	6q27
	Type of gene	protein-coding	protein-coding
	Description	synaptojanin-2inositol phosphate 5'-phosphatase 2inositol polyphosphate-5-phosphatase Hphosphoinositide 5-phosphatasesynaptic inositol 1,4,5-trisphosphate 5-phosphatase 2	kinesin-like protein KIF25kinesin-like 3kinesin-like protein 3
	Modification date	20180523	20180523
	UniProtAcc	O15056	Q9UIL4
	Ensembl transtripts involved in fusion gene	ENST00000367121, ENST00000367122, ENST00000355585, ENST00000449859, ENST00000367112,	ENST00000515361, ENST00000443060, ENST00000354419, ENST00000351261,
Fusion gene scores	* DoF score	7 X 7 X 5=245	2 X 2 X 2=8
	# samples	7	2
	** MAII score	log2(7/245*10)=-1.8073549220576 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context	PubMed: SYNJ2 [Title/Abstract] AND KIF25 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	KIF25	GO:0046603	negative regulation of mitotic centrosome separation	28263957
Tgene	KIF25	GO:0051294	establishment of spindle orientation	28263957
Tgene	KIF25	GO:0051647	nucleus localization	28263957

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	PRAD	TCGA-ZG-A8QZ-01A	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-intron	ENST00000367121	ENST00000515361	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000367121	ENST00000443060	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000367121	ENST00000354419	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000367121	ENST00000351261	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000367122	ENST00000515361	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000367122	ENST00000443060	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000367122	ENST00000354419	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000367122	ENST00000351261	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000355585	ENST00000515361	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000355585	ENST00000443060	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000355585	ENST00000354419	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
5CDS-intron	ENST00000355585	ENST00000351261	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
intron-intron	ENST00000449859	ENST00000515361	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
intron-intron	ENST00000449859	ENST00000443060	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
intron-intron	ENST00000449859	ENST00000354419	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
intron-intron	ENST00000449859	ENST00000351261	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
intron-intron	ENST00000367112	ENST00000515361	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
intron-intron	ENST00000367112	ENST00000443060	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
intron-intron	ENST00000367112	ENST00000354419	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+
intron-intron	ENST00000367112	ENST00000351261	SYNJ2	chr6	158403120	+	KIF25	chr6	168439233	+

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FusionProtFeatures for SYNJ2_KIF25

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SYNJ2 O15056	KIF25 Q9UIL4

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Fusion gene ID: 36936

FusionGeneSummary for SYNJ2_KIF25

FusionProtFeatures for SYNJ2_KIF25