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Fusion gene ID: 36879 |
FusionGeneSummary for SYMPK_ZNF573 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYMPK_ZNF573 | Fusion gene ID: 36879 | Hgene | Tgene | Gene symbol | SYMPK | ZNF573 | Gene ID | 8189 | 126231 |
| Gene name | symplekin | zinc finger protein 573 | |
| Synonyms | SPK|SYM | - | |
| Cytomap | 19q13.32 | 19q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | symplekin | zinc finger protein 573 | |
| Modification date | 20180519 | 20180522 | |
| UniProtAcc | Q92797 | Q86YE8 | |
| Ensembl transtripts involved in fusion gene | ENST00000598155, ENST00000245934, | ENST00000392138, ENST00000590414, ENST00000339503, ENST00000536220, ENST00000357309, ENST00000585724, ENST00000480587, | |
| Fusion gene scores | * DoF score | 9 X 7 X 6=378 | 2 X 2 X 2=8 |
| # samples | 8 | 2 | |
| ** MAII score | log2(8/378*10)=-2.24031432933371 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context | PubMed: SYMPK [Title/Abstract] AND ZNF573 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SYMPK | GO:0035307 | positive regulation of protein dephosphorylation | 20861839 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-66-2759-01A | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| intron-3CDS | ENST00000598155 | ENST00000392138 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| intron-3CDS | ENST00000598155 | ENST00000590414 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| intron-3CDS | ENST00000598155 | ENST00000339503 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| intron-3CDS | ENST00000598155 | ENST00000536220 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| intron-3CDS | ENST00000598155 | ENST00000357309 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| intron-3UTR | ENST00000598155 | ENST00000585724 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| intron-intron | ENST00000598155 | ENST00000480587 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| Frame-shift | ENST00000245934 | ENST00000392138 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| Frame-shift | ENST00000245934 | ENST00000590414 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| Frame-shift | ENST00000245934 | ENST00000339503 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| Frame-shift | ENST00000245934 | ENST00000536220 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| Frame-shift | ENST00000245934 | ENST00000357309 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| 5CDS-3UTR | ENST00000245934 | ENST00000585724 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
| 5CDS-intron | ENST00000245934 | ENST00000480587 | SYMPK | chr19 | 46330768 | - | ZNF573 | chr19 | 38231095 | - |
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FusionProtFeatures for SYMPK_ZNF573 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYMPK | ZNF573 |