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Fusion gene ID: 36870 |
FusionGeneSummary for SYK_SYK |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYK_SYK | Fusion gene ID: 36870 | Hgene | Tgene | Gene symbol | SYK | SYK | Gene ID | 6850 | 6850 |
| Gene name | spleen associated tyrosine kinase | spleen associated tyrosine kinase | |
| Synonyms | p72-Syk | p72-Syk | |
| Cytomap | 9q22.2 | 9q22.2 | |
| Type of gene | protein-coding | protein-coding | |
| Description | tyrosine-protein kinase SYKspleen tyrosine kinase | tyrosine-protein kinase SYKspleen tyrosine kinase | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | P43405 | P43405 | |
| Ensembl transtripts involved in fusion gene | ENST00000375751, ENST00000375754, ENST00000375747, ENST00000476708, ENST00000375746, | ENST00000375751, ENST00000375754, ENST00000375747, ENST00000476708, ENST00000375746, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 5 X 4 X 4=80 |
| # samples | 2 | 5 | |
| ** MAII score | log2(2/8*10)=1.32192809488736 | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SYK [Title/Abstract] AND SYK [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SYK | GO:0006468 | protein phosphorylation | 17681949 |
| Hgene | SYK | GO:0007159 | leukocyte cell-cell adhesion | 12885943 |
| Hgene | SYK | GO:0030593 | neutrophil chemotaxis | 12885943 |
| Tgene | SYK | GO:0006468 | protein phosphorylation | 17681949 |
| Tgene | SYK | GO:0007159 | leukocyte cell-cell adhesion | 12885943 |
| Tgene | SYK | GO:0030593 | neutrophil chemotaxis | 12885943 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChiTaRS3.1 | CB242349 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3UTR | ENST00000375751 | ENST00000375751 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375751 | ENST00000375754 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375751 | ENST00000375747 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-intron | ENST00000375751 | ENST00000476708 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375751 | ENST00000375746 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375754 | ENST00000375751 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375754 | ENST00000375754 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375754 | ENST00000375747 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-intron | ENST00000375754 | ENST00000476708 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375754 | ENST00000375746 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375747 | ENST00000375751 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375747 | ENST00000375754 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375747 | ENST00000375747 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-intron | ENST00000375747 | ENST00000476708 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375747 | ENST00000375746 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| intron-3UTR | ENST00000476708 | ENST00000375751 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| intron-3UTR | ENST00000476708 | ENST00000375754 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| intron-3UTR | ENST00000476708 | ENST00000375747 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| intron-intron | ENST00000476708 | ENST00000476708 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| intron-3UTR | ENST00000476708 | ENST00000375746 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375746 | ENST00000375751 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375746 | ENST00000375754 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375746 | ENST00000375747 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-intron | ENST00000375746 | ENST00000476708 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
| 3UTR-3UTR | ENST00000375746 | ENST00000375746 | SYK | chr9 | 93660655 | - | SYK | chr9 | 93660494 | + |
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FusionProtFeatures for SYK_SYK |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYK | SYK |