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Fusion gene ID: 36866 |
FusionGeneSummary for SYDE2_TCTN1 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SYDE2_TCTN1 | Fusion gene ID: 36866 | Hgene | Tgene | Gene symbol | SYDE2 | TCTN1 | Gene ID | 84144 | 79600 |
| Gene name | synapse defective Rho GTPase homolog 2 | tectonic family member 1 | |
| Synonyms | - | JBTS13|TECT1 | |
| Cytomap | 1p22.3 | 12q24.11 | |
| Type of gene | protein-coding | protein-coding | |
| Description | rho GTPase-activating protein SYDE2protein syd-1 homolog 2synapse defective 1, Rho GTPase, homolog 2synapse defective protein 1 homolog 2 | tectonic-1 | |
| Modification date | 20180519 | 20180519 | |
| UniProtAcc | Q5VT97 | Q2MV58 | |
| Ensembl transtripts involved in fusion gene | ENST00000341460, | ENST00000550703, ENST00000551590, ENST00000397655, ENST00000471804, ENST00000377654, ENST00000397659, ENST00000551555, | |
| Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 3 X 2=18 |
| # samples | 3 | 3 | |
| ** MAII score | log2(3/8*10)=1.90689059560852 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SYDE2 [Title/Abstract] AND TCTN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A23V-01A | SYDE2 | chr1 | 85665935 | - | TCTN1 | chr12 | 111057641 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000341460 | ENST00000550703 | SYDE2 | chr1 | 85665935 | - | TCTN1 | chr12 | 111057641 | + |
| Frame-shift | ENST00000341460 | ENST00000551590 | SYDE2 | chr1 | 85665935 | - | TCTN1 | chr12 | 111057641 | + |
| Frame-shift | ENST00000341460 | ENST00000397655 | SYDE2 | chr1 | 85665935 | - | TCTN1 | chr12 | 111057641 | + |
| Frame-shift | ENST00000341460 | ENST00000471804 | SYDE2 | chr1 | 85665935 | - | TCTN1 | chr12 | 111057641 | + |
| 5CDS-5UTR | ENST00000341460 | ENST00000377654 | SYDE2 | chr1 | 85665935 | - | TCTN1 | chr12 | 111057641 | + |
| 5CDS-5UTR | ENST00000341460 | ENST00000397659 | SYDE2 | chr1 | 85665935 | - | TCTN1 | chr12 | 111057641 | + |
| 5CDS-5UTR | ENST00000341460 | ENST00000551555 | SYDE2 | chr1 | 85665935 | - | TCTN1 | chr12 | 111057641 | + |
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FusionProtFeatures for SYDE2_TCTN1 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SYDE2 | TCTN1 |